Afatinib Dimaleate with or without Cetuximab in Treating Patients with Newly Diagnosed Stage IV or Recurrent, EGFR Mutation Positive Non-small Cell Lung Cancer

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Status: Active

Description

This randomized phase II trial studies how well afatinib dimaleate with or without cetuximab works in treating patients with newly diagnosed stage IV or recurrent (has come back), epidermal growth factor receptor (EGFR) mutation positive non-small cell lung cancer. Afatinib dimaleate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as cetuximab, may block tumor growth in different ways by targeting certain cells. It is not yet known whether afatinib dimaleate is more effective when given alone or with cetuximab in treating patients with non-small cell lung cancer.

Eligibility Criteria

Inclusion Criteria

  • Patients must have histologically or cytologically confirmed stage IV (American Joint Committee on Cancer [AJCC] 7th Edition) or recurrent non-small cell lung cancer (NSCLC)
  • Patients must have documented presence of an EGFR exon 19 deletion or exon 21 (L858R) substitution mutation; T790M mutation or other molecular abnormality will be allowed as long as it accompanies one of the mutations listed above; EGFR testing must be performed using a Food and Drug Administration (FDA)-approved test or in a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory.
  • Patients must have tissue available and must agree to submission of tissue and blood; one to two paraffin-embedded tissue blocks or 15-20 unstained slides are requested (a minimum of 12 slides is required); cytology (i.e. fine-needle aspirations, pleural effusion specimens) is acceptable if a cell block or sufficient unstained slides are available; tumor material must be reviewed by a local pathologist who must confirm that at least 100 viable tumor cells are present in the sample and sign the S1403 Pathology Review Form prior to registration; patients must also be willing to submit blood samples for correlative research at baseline, during treatment and at progression
  • Patients enrolled at sites participating in the Repeat Biopsy Study must agree to submission of tissue obtained by a repeat biopsy performed at the time of disease progression
  • Patients must not have received any prior systemic anticancer therapy for advanced or metastatic disease including chemotherapy or EGFR tyrosine kinase inhibitor therapy (including gefitinib, erlotinib, afatinib, or any experimental EGFR tyrosine kinase inhibitors [TKI] agents); prior chemotherapy for non-metastatic disease (i.e. adjuvant therapy or concurrent chemo-radiotherapy) is allowed as long as > 12 months has passed since completion of therapy; adjuvant EGFR-directed therapy is not allowed; local therapy (i.e. palliative radiotherapy) is allowed as long as a period of 7 days has passed since the last dose was received and the patient has recovered from any associated toxicity at the time of registration
  • Patients may have measurable or non-measurable disease documented by computed tomography (CT) or magnetic resonance imaging (MRI) within 42 days prior to registration; the CT from a combined positron emission tomography (PET)/CT may be used only if it is of diagnostic quality; laboratory parameters are not acceptable as the only evidence of disease; in order to qualify as measurable, measurable disease must be outside previous radiation field; all disease must be assessed and documented on the Baseline Tumor Assessment Form (Response Evaluation Criteria in Solid Tumors [RECIST] 1.1)
  • Patients must have a CT or MRI scan of the brain to evaluate for central nervous system (CNS) disease within 42 days prior to registration; patient must not have symptomatic brain metastases or evidence of leptomeningeal carcinomatosis; patients with asymptomatic brain metastases are eligible if off of steroids for at least 7 days prior to registration without development of symptoms
  • Patients must not have any known clinically active interstitial lung disease
  • Obtained within 28 days prior to registration: Absolute neutrophil count (ANC) >= 1,500/mcL
  • Obtained within 28 days prior to registration: Platelets >= 75,000/mcL
  • Obtained within 28 days prior to registration: Hemoglobin >= 9 g/dL
  • Obtained within 28 days prior to registration: Total bilirubin =< 1.5 x institutional upper limit of normal (IULN)
  • Obtained within 28 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or =< 5 x IULN for patients with known liver metastases)
  • Obtained within 28 days prior to registration: Serum creatinine =< 1.5 x IULN OR measured or calculated creatinine clearance >= 60 mL/min
  • Patients must not have significant gastrointestinal disorders with diarrhea as a major symptom (e.g. Crohn’s disease, malabsorption, etc)
  • Patients must be able to swallow medication by oral route
  • Patients must not have a history of clinically relevant cardiovascular abnormalities such as uncontrolled hypertension, congestive heart failure New York Heart Association (NYHA) classification of 3, unstable angina or poorly controlled arrhythmia or myocardial infarction within 6 months prior to registration; if clinically indicated, echocardiogram or multigated acquisition (MUGA) must be performed and cardiac ejection fraction must be >= 50%
  • Patients must not have had major surgery within 28 days prior to registration or be scheduled for surgery during the projected course of protocol treatment; tumor biopsy is allowed
  • Patients must not have a known history of active hepatitis B infection (defined as presence of hepatitis B surface antigen [Hep B sAg] and/ or Hep B deoxyribonucleic acid [DNA]), active hepatitis C infection (defined as presence of hepatitis C [Hep C] ribonucleic acid [RNA]) and/or known human immunodeficiency virus (HIV) seropositive
  • Patients must not have any other concomitant serious illness or organ system dysfunction which in the opinion of the investigator would either compromise patient safety or interfere with the evaluation of the safety of the study drug
  • Patients must not be planning to receive any other investigational agents during the course of protocol treatment
  • Patients must not have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to afatinib and/or cetuximab
  • Prestudy history and physical must be obtained with 28 days prior to registration
  • Patients must have Zubrod performance status of 0 - 2
  • No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years
  • Patients must not be pregnant or nursing; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
  • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
  • As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

Locations & Contacts

Arkansas

Jonesboro
Fowler Family Center for Cancer Care
Status: Active
Contact: Carroll Dean Scroggin
Phone: 870-936-7000

California

Anaheim
Kaiser Permanente-Anaheim
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Arroyo Grande
PCR Oncology
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Auburn
Sutter Auburn Faith Hospital
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sutter Cancer Centers Radiation Oncology Services-Auburn
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Bakersfield
AIS Cancer Center at San Joaquin Community Hospital
Status: Active
Contact: David R. Gandara
Phone: 916-734-3089
Baldwin Park
Kaiser Permanente-Baldwin Park
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Bellflower
Kaiser Permanente-Bellflower
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Burlingame
Mills-Peninsula Medical Center
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Castro Valley
Eden Hospital Medical Center
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Davis
Sutter Davis Hospital
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Fontana
Kaiser Permanente-Fontana
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Fremont
Palo Alto Medical Foundation-Fremont
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Harbor City
Kaiser Permanente - Harbor City
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Irvine
Kaiser Permanente-Irvine
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
La Jolla
UC San Diego Moores Cancer Center
Status: Active
Contact: Lyudmila Alexandrovna Bazhenova
Phone: 858-822-5354 Email: cancercto@ucsd.edu
Los Angeles
Kaiser Permanente Los Angeles Medical Center
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Kaiser Permanente-Cadillac
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Marysville
Fremont - Rideout Cancer Center
Status: Active
Contact: David R. Gandara
Phone: 916-734-3089
Merced
Mercy UC Davis Cancer Center
Status: Active
Contact: Parminder S. Sidhu
Phone: 916-734-3089
Modesto
Memorial Medical Center
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Mountain View
Palo Alto Medical Foundation-Camino Division
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Palo Alto Medical Foundation-Gynecologic Oncology
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Novato
Sutter Cancer Research Consortium
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Palo Alto
Palo Alto Medical Foundation Health Care
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Panorama City
Kaiser Permanente - Panorama City
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Rancho Mirage
Eisenhower Medical Center
Status: Active
Contact: Davood Vafai
Phone: 760-834-3798
Riverside
Kaiser Permanente-Riverside
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sutter Roseville Medical Center
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sacramento
Sutter Medical Center Sacramento
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
University of California Davis Comprehensive Cancer Center
Status: Active
Contact: David R. Gandara
Phone: 916-734-3089
San Diego
Kaiser Permanente-San Diego Mission
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Kaiser Permanente-San Diego Zion
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
San Francisco
California Pacific Medical Center-Pacific Campus
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
San Marcos
Kaiser Permanente-San Marcos
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Santa Rosa
Sutter Pacific Medical Foundation
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Truckee
Gene Upshaw Memorial Tahoe Forest Cancer Center
Status: Active
Contact: David R. Gandara
Phone: 916-734-3089
Vacaville
Northbay Cancer Center
Status: Active
Contact: Brian G. Vikstrom
Phone: 707-624-8007
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Vallejo
Sutter Solano Medical Center / Cancer Center
Status: Active
Contact: Ari David Baron
Phone: 415-209-2686 Email: bernicl@sutterhealth.org
Woodland Hills
Kaiser Permanente-Woodland Hills
Status: Active
Contact: Han A. Koh
Phone: 626-564-3455

Connecticut

Derby
Smilow Cancer Hospital-Derby Care Center
Status: Active
Contact: Sarah B. Goldberg
Phone: 203-785-5702
Fairfield
Smilow Cancer Hospital Care Center-Fairfield
Status: Active
Contact: Sarah B. Goldberg
Phone: 203-785-5702
Guilford
Yale-New Haven Shoreline Medical Center
Status: Active
Contact: Sarah B. Goldberg
Phone: 203-785-5702
Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Status: Active
Contact: Sarah B. Goldberg
Phone: 203-785-5702
Middletown
Middlesex Hospital
Status: Active
Contact: Susanna Hong
Phone: 860-358-2058 Email: beth_slifer@midhosp.org
New Haven
Yale University
Status: Active
Contact: Sarah B. Goldberg
Phone: 203-785-5702
North Haven
Yale-New Haven Hospital North Haven Medical Center
Status: Active
Contact: Sarah B. Goldberg
Phone: 203-785-5702
Orange
Smilow Cancer Hospital-Orange Care Center
Status: Active
Contact: Sarah B. Goldberg
Phone: 203-785-5702
Torrington
Smilow Cancer Hospital-Torrington Care Center
Status: Active
Contact: Sarah B. Goldberg
Phone: 203-785-5702
Trumbull
Smilow Cancer Hospital Care Center-Trumbull
Status: Active
Contact: Sarah B. Goldberg
Phone: 203-785-5702
Waterbury
Smilow Cancer Hospital-Waterbury Care Center
Status: Active
Contact: Sarah B. Goldberg
Phone: 203-785-5702

Florida

Jacksonville
Baptist MD Anderson Cancer Center
Status: Active
Contact: John Ho Vu
Phone: 904-202-7051
Pensacola
Sacred Heart Hospital
Status: Active
Contact: Yazan Alsayed
Phone: 850-416-4611 Email: ttamayo@shhpens.org

Georgia

Macon
Central Georgia Gynecologic Oncology
Status: Temporarily closed to accrual
Contact: Frederick M. Schnell
Phone: 478-633-1226
Medical Center of Central Georgia
Status: Active
Contact: Frederick M. Schnell
Phone: 478-633-1226
Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's / Candler
Status: Active
Contact: Howard A. Zaren
Phone: 912-819-5704
Low Country Cancer Care Associates PC
Status: Active
Contact: Christopher E. Haberman
Phone: 912-692-2000
Memorial Health University Medical Center
Status: Active
Contact: Christopher E. Haberman
Phone: 912-350-8568
Summit Cancer Care-Candler
Status: Active
Contact: Christopher E. Haberman Email: protocols@swog.org
Summit Cancer Care-Memorial
Status: Active
Contact: Christopher E. Haberman
Phone: 912-354-6187
Valdosta
South Georgia Medical Center / Pearlman Cancer Center
Status: Active
Contact: Samuel N. Ofori
Phone: 229-259-4628 Email: maryann.heddon@sgmc.org

Hawaii

Aiea
Hawaii Oncology Inc-Pali Momi
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Pali Momi Medical Center
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
The Cancer Center of Hawaii-Pali Momi
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Honolulu
Hawaii Cancer Care Inc-Liliha
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Hawaii Cancer Care Inc-POB II
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Hawaii Oncology Inc-Kuakini
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Hawaii Oncology Inc-POB I
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Island Urology
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Kapiolani Medical Center for Women and Children
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Kuakini Medical Center
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Queen's Medical Center
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Straub Clinic and Hospital
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
The Cancer Center of Hawaii-Liliha
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
University of Hawaii Cancer Center
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979
Lihue
Wilcox Memorial Hospital and Kauai Medical Clinic
Status: Active
Contact: Jeffrey L. Berenberg
Phone: 808-586-2979

Idaho

Boise
Saint Alphonsus Cancer Care Center-Boise
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Coeur D'Alene
Kootenai Medical Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Emmett
Walter Knox Memorial Hospital
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Meridian
Idaho Urologic Institute-Meridian
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Nampa
Saint Alphonsus Medical Center-Nampa
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Post Falls
Kootenai Cancer Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Sandpoint
Kootenai Cancer Clinic
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org

Illinois

Aurora
Rush - Copley Medical Center
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Bloomington
Illinois CancerCare-Bloomington
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Canton
Illinois CancerCare-Canton
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Carbondale
Memorial Hospital of Carbondale
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Carterville
SIH Cancer Institute
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Carthage
Illinois CancerCare-Carthage
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Centralia
Centralia Oncology Clinic
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Danville
Carle on Vermilion
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Decatur
Cancer Care Specialists of Central Illinois
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Decatur Memorial Hospital
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Effingham
Carle Physician Group-Effingham
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Crossroads Cancer Center
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Eureka
Illinois CancerCare-Eureka
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Galesburg
Illinois CancerCare-Galesburg
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Western Illinois Cancer Treatment Center
Status: Active
Contact: James Lloyd Wade
Phone: 309-344-2831
Kewanee
Illinois CancerCare-Kewanee Clinic
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Macomb
Illinois CancerCare-Macomb
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Mattoon
Carle Physician Group-Mattoon / Charleston
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Maywood
Loyola University Medical Center
Status: Active
Contact: Courtney Regan Wagner
Phone: 708-226-4357
Moline
Garneau, Stewart C MD (UIA Investigator)
Status: Active
Contact: David Martens Spector
Phone: 309-277-2900
Spector, David MD (UIA Investigator)
Status: Active
Contact: David Martens Spector
Phone: 309-779-4200
Trinity Medical Center
Status: Active
Contact: David Martens Spector
Phone: 309-779-2000
Mount Vernon
Good Samaritan Regional Health Center
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Ottawa
Illinois CancerCare-Ottawa Clinic
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Radiation Oncology of Northern Illinois
Status: Temporarily closed to accrual
Contact: James Lloyd Wade
Phone: 309-243-3605
Pekin
Illinois CancerCare-Pekin
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Peoria
Illinois CancerCare-Peoria
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Methodist Medical Center of Illinois
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
OSF Saint Francis Medical Center
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Peru
Illinois CancerCare-Peru
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Valley Radiation Oncology
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Princeton
Illinois CancerCare-Princeton
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Rockford
SwedishAmerican Regional Cancer Center / ACT
Status: Active
Contact: Harvey E. Einhorn
Phone: 779-696-9400 Email: cancercare@swedishamerican.org
Springfield
Memorial Medical Center
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Southern Illinois University School of Medicine
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Springfield Clinic
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Swansea
Cancer Care Specialists of Illinois-Swansea
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Memorial and Saint Elizabeth's Health Care Services LLP
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Urbana
Carle Cancer Center
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
The Carle Foundation Hospital
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Yorkville
Rush-Copley Healthcare Center
Status: Active
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com

Indiana

Evansville
Deaconess Clinic Downtown
Status: Active
Contact: Yujie Zhao
Phone: 877-654-0311
Michigan City
Franciscan Saint Anthony Health-Michigan City
Status: Temporarily closed to accrual
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Woodland Cancer Care Center
Status: Temporarily closed to accrual
Contact: Yujie Zhao
Phone: 630-978-6212 Email: Cancer.Research@rushcopley.com
Newburgh
Chancellor Center for Oncology
Status: Active
Contact: Yujie Zhao
Phone: 812-426-9576
Richmond
Reid Health
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu

Iowa

Ames
Mary Greeley Medical Center
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
McFarland Clinic PC - Ames
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
Bettendorf
Constantinou, Costas L MD (UIA Investigator)
Status: Active
Contact: David Martens Spector
Phone: 563-359-9876
Boone
McFarland Clinic PC-Boone
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
Fort Dodge
McFarland Clinic PC-Trinity Cancer Center
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
Jefferson
McFarland Clinic PC-Jefferson
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
Marshalltown
McFarland Clinic PC-Marshalltown
Status: Active
Contact: Joseph James Merchant
Phone: 515-239-2621
Sioux City
Siouxland Regional Cancer Center
Status: Active
Contact: Donald B. Wender
Phone: 712-252-0088

Kansas

Chanute
Cancer Center of Kansas - Chanute
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Coffeyville
Coffeyville Regional Medical Center
Status: Active
Contact: Chao Hui Huang
Phone: 620-252-1606
Dodge City
Cancer Center of Kansas - Dodge City
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
El Dorado
Cancer Center of Kansas - El Dorado
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Fort Scott
Cancer Center of Kansas - Fort Scott
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Garden City
Central Care Cancer Center - Garden City
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Saint Catherine Hospital
Status: Temporarily closed to accrual
Contact: Chao Hui Huang
Phone: 800-592-5110 Email: info@cccancer.com
Great Bend
Central Care Cancer Center - Great Bend
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Saint Rose Ambulatory and Surgery Center
Status: Temporarily closed to accrual
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Hays
Hays Medical Center
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Independence
Cancer Center of Kansas-Independence
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Kansas City
University of Kansas Cancer Center
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
University of Kansas Cancer Center-West
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Kingman
Cancer Center of Kansas-Kingman
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Lawrence
Lawrence Memorial Hospital
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Lenexa
Kansas Institute of Medicine Cancer and Blood Center
Status: Temporarily closed to accrual
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Minimally Invasive Surgery Hospital
Status: Temporarily closed to accrual
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Liberal
Cancer Center of Kansas-Liberal
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Manhattan
Cancer Center of Kansas-Manhattan
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
McPherson
Cancer Center of Kansas - McPherson
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Newton
Cancer Center of Kansas - Newton
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Olathe
Olathe Medical Center
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Overland Park
Menorah Medical Center
Status: Temporarily closed to accrual
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Saint Luke's South Hospital
Status: Temporarily closed to accrual
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
University of Kansas Cancer Center-Overland Park
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Parsons
Cancer Center of Kansas - Parsons
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Pittsburg
Via Christi Hospital-Pittsburg
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Prairie Village
Kansas City NCI Community Oncology Research Program
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Pratt
Cancer Center of Kansas - Pratt
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Salina
Cancer Center of Kansas - Salina
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Salina Regional Health Center
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Topeka
Saint Francis Hospital and Medical Center - Topeka
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Wellington
Cancer Center of Kansas - Wellington
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Westwood
University of Kansas Hospital-Westwood Cancer Center
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Wichita
Associates In Womens Health
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Cancer Center of Kansas - Wichita
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Cancer Center of Kansas-Wichita Medical Arts Tower
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Via Christi Regional Medical Center
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374
Winfield
Cancer Center of Kansas - Winfield
Status: Active
Contact: Shaker R. Dakhil
Phone: 316-268-5374

Kentucky

Crestview Hills
Oncology Hematology Care Inc-Crestview
Status: Temporarily closed to accrual
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu

Maine

Augusta
Harold Alfond Center for Cancer Care
Status: Active
Contact: Thomas H. Openshaw
Phone: 207-973-4274
Bangor
Eastern Maine Medical Center
Status: Active
Contact: Thomas H. Openshaw
Phone: 207-973-4274
Belfast
Waldo County General Hospital
Status: Active
Contact: Peter Rubin
Phone: 207-338-2500
Biddeford
MaineHealth / SMHC Cancer Care and Blood Disorders-Biddeford
Status: Active
Contact: Peter Rubin Email: LLemire@mmc.org
Brewer
Lafayette Family Cancer Center-EMMC
Status: Active
Contact: Thomas H. Openshaw
Phone: 207-973-4274
Rockport
Penobscot Bay Medical Center
Status: Active
Contact: Thomas H. Openshaw
Phone: 207-973-4274
Sanford
MaineHealth / SMHC Cancer Care and Blood Disorders-Sanford
Status: Active
Contact: Peter Rubin Email: LLemire@mmc.org

Massachusetts

Beverly
Beverly Hospital
Status: Temporarily closed to accrual
Contact: Angus P. McIntyre
Phone: 781-744-8027
Burlington
Lahey Hospital and Medical Center
Status: Active
Contact: Krishna Soujanya Gunturu
Phone: 781-744-8027
Gloucester
Addison Gilbert Hospital
Status: Temporarily closed to accrual
Contact: Angus P. McIntyre
Phone: 781-744-8027
Winchester
Winchester Hospital
Status: Active
Contact: Krishna Soujanya Gunturu
Phone: 781-744-8027

Michigan

Ann Arbor
Saint Joseph Mercy Hospital
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
University of Michigan Comprehensive Cancer Center
Status: Active
Contact: Gregory Peter Kalemkerian
Phone: 800-865-1125
Battle Creek
Bronson Battle Creek
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Brighton
IHA Hematology Oncology Consultants-Brighton
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Saint Joseph Mercy Brighton
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Canton
IHA Hematology Oncology Consultants-Canton
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Saint Joseph Mercy Canton
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Caro
Caro Cancer Center
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Chelsea
IHA Hematology Oncology Consultants-Chelsea
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Saint Joseph Mercy Chelsea
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Clarkston
Hematology Oncology Consultants-Clarkston
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Newland Medical Associates-Clarkston
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Dearborn
Beaumont Hospital-Dearborn
Status: Temporarily closed to accrual
Contact: Philip J. Stella
Phone: 248-551-7695
Detroit
Saint John Hospital and Medical Center
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Wayne State University / Karmanos Cancer Institute
Status: Active
Contact: Antoinette J. Wozniak
Phone: 313-576-9363
East China
Great Lakes Cancer Management Specialists-Doctors Park
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Farmington Hills
Weisberg Cancer Treatment Center
Status: Active
Contact: Antoinette J. Wozniak
Phone: 313-576-9363
Flint
Genesee Cancer and Blood Disease Treatment Center
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Genesee Hematology Oncology PC
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Genesys Hurley Cancer Institute
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Hurley Medical Center
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Gorsse Pointe Woods
Lymphoma Clinic of Michigan
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Grand Rapids
Mercy Health Saint Mary's
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Spectrum Health at Butterworth Campus
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Michigan Breast Specialists-Grosse Pointe Woods
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Jackson
Allegiance Health
Status: Temporarily closed to accrual
Contact: Philip J. Stella
Phone: 517-788-4800
Kalamazoo
Borgess Medical Center
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Bronson Methodist Hospital
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
West Michigan Cancer Center
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Lansing
Sparrow Hospital
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Livonia
Hope Cancer Clinic
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Saint Mary Mercy Hospital
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Macomb Township
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Michigan Breast Specialists-Macomb Township
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Marlette
Saint Mary's Oncology / Hematology Associates of Marlette
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Marquette
UP Health System Hematology Oncology Marquette
Status: Temporarily closed to accrual
Contact: Sheetal Suman Acharya
Phone: 906-225-4600 Email: Dianna.Larson@mghs.org
UP Health System Marquette
Status: Temporarily closed to accrual
Contact: Sheetal Suman Acharya
Phone: 906-225-4600 Email: Dianna.Larson@mghs.org
Monroe
Monroe Cancer Center
Status: Active
Contact: Abhijit B. Saste
Phone: 419-824-1842
Muskegon
Mercy Health Mercy Campus
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Niles
Lakeland Hospital Niles
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Pontiac
21st Century Oncology-Pontiac
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Hope Cancer Center
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Newland Medical Associates-Pontiac
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Saint Joseph Mercy Oakland
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Port Huron
Huron Medical Center PC
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013 Email: research@sncrf.org
Lake Huron Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Reed City
Spectrum Health Reed City Hospital
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Rochester Hills
Great Lakes Cancer Management Specialists-Rochester Hills
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Saginaw
Oncology Hematology Associates of Saginaw Valley PC
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Saint Mary's of Michigan
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Saint Joseph
Lakeland Hospital
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Marie Yeager Cancer Center
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Sterling Heights
Bhadresh Nayak MD PC-Sterling Heights
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Tawas City
Saint Joseph Health System-Tawas City
Status: Active
Contact: Philip J. Stella
Phone: 734-712-3671 Email: stephanie.couch@stjoeshealth.org
Traverse City
Munson Medical Center
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Warren
Advanced Breast Care Center PLLC
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Bhadresh Nayak MD PC-Warren
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Great Lakes Cancer Management Specialists-Macomb Professional Building
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Macomb Hematology Oncology PC
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Michigan Breast Specialists-Warren
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Saint John Macomb-Oakland Hospital
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
West Branch
Saint Mary's Oncology / Hematology Associates of West Branch
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Wyoming
Metro Health Hospital
Status: Active
Contact: Kathleen J. Yost
Phone: 616-391-1230 Email: crcwm-regulatory@crcwm.org
Ypsilanti
Huron Gastroenterology PC
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
IHA Hematology Oncology Consultants-Ann Arbor
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954

Minnesota

Bemidji
Sanford Clinic North-Bemidgi
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Burnsville
Fairview Ridges Hospital
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Coon Rapids
Mercy Hospital
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Edina
Fairview-Southdale Hospital
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Fridley
Unity Hospital
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Maple Grove
Fairview Maple Grove Medical Center
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Maplewood
Minnesota Oncology Hematology PA-Maplewood
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Minneapolis
Abbott-Northwestern Hospital
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Health Partners Inc
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Hennepin County Medical Center
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
New Ulm
New Ulm Medical Center
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Robbinsdale
North Memorial Medical Health Center
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
United Hospital
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Shakopee
Saint Francis Regional Medical Center
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Stillwater
Lakeview Hospital
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Waconia
Ridgeview Medical Center
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Willmar
Rice Memorial Hospital
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Wyoming
Fairview Lakes Medical Center
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com

Mississippi

New Albany
Baptist Memorial Hospital and Cancer Center-Union County
Status: Active
Contact: Raymond Uyiosa Osarogiagbon
Phone: 870-936-7000
Oxford
Baptist Memorial Hospital and Cancer Center-Oxford
Status: Active
Contact: Raymond Uyiosa Osarogiagbon
Phone: 870-936-7000
Pascagoula
Singing River Hospital
Status: Active
Contact: James E. Clarkson
Phone: 228-809-5292
Southhaven
Baptist Memorial Hospital and Cancer Center-Desoto
Status: Active
Contact: Raymond Uyiosa Osarogiagbon
Phone: 870-936-7000

Missouri

Bolivar
Central Care Cancer Center - Bolivar
Status: Active
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Bonne Terre
Parkland Health Center-Bonne Terre
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Branson
Cox Cancer Center Branson
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Cape Girardeau
Saint Francis Medical Center
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Southeast Cancer Center
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Independence
Centerpoint Medical Center LLC
Status: Temporarily closed to accrual
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Jefferson City
Capital Region Medical Center-Goldschmidt Cancer Center
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Joplin
Freeman Health System
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Mercy Hospital Joplin
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Kansas City
Heartland Hematology and Oncology Associates Incorporated
Status: Temporarily closed to accrual
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Kansas City Veterans Affairs Medical Center
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Research Medical Center
Status: Temporarily closed to accrual
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Saint Luke's Hospital of Kansas City
Status: Temporarily closed to accrual
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
The University of Kansas Cancer Center-North
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
The University of Kansas Cancer Center-South
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Truman Medical Center
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Lee's Summit
Saint Luke's East - Lee's Summit
Status: Temporarily closed to accrual
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
The University of Kansas Cancer Center-Lee's Summit
Status: Active
Contact: Chao Hui Huang
Phone: 913-945-7552 Email: ctnursenav@kumc.edu
Liberty
Liberty Radiation Oncology Center
Status: Temporarily closed to accrual
Contact: Rakesh Gaur
Phone: 913-948-5588 Email: aroland@kccop.org
Rolla
Delbert Day Cancer Institute at PCRMC
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Mercy Clinic-Rolla-Cancer and Hematology
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Saint Joseph
Heartland Regional Medical Center
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Saint Louis
Mercy Hospital Saint Louis
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Missouri Baptist Medical Center
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Saint Louis Cancer and Breast Institute-South City
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Springfield
CoxHealth South Hospital
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Mercy Hospital Springfield
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
Sullivan
Missouri Baptist Sullivan Hospital
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605
Sunset Hills
Missouri Baptist Outpatient Center-Sunset Hills
Status: Active
Contact: James Lloyd Wade
Phone: 309-243-3605

Montana

Billings
Billings Clinic Cancer Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Saint Vincent Healthcare
Status: Temporarily closed to accrual
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Bozeman
Bozeman Deaconess Hospital
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Great Falls
Benefis Healthcare- Sletten Cancer Institute
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Helena
Saint Peter's Community Hospital
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Kalispell
Kalispell Regional Medical Center
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Missoula
Community Medical Hospital
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Saint Patrick Hospital - Community Hospital
Status: Temporarily closed to accrual
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org

Nebraska

Lincoln
Nebraska Cancer Research Center
Status: Active
Contact: Gamini S. Soori
Phone: 402-991-8070 Email: mwilwerding@mvcc.cc
Nebraska Hematology and Oncology
Status: Active
Contact: Gamini S. Soori
Phone: 402-991-8070 Email: mwilwerding@mvcc.cc
Southeast Nebraska Cancer Center
Status: Active
Contact: Gamini S. Soori
Phone: 402-991-8070 Email: mwilwerding@mvcc.cc
Norfolk
Faith Regional Health Services Carson Cancer Center
Status: Active
Contact: Gamini S. Soori
Phone: 402-991-8070 Email: mwilwerding@mvcc.cc
North Platte
Great Plains Health Callahan Cancer Center
Status: Active
Contact: Gamini S. Soori
Phone: 402-991-0070 Email: mwilwerding@canceralliance-ne.org
Omaha
Nebraska Cancer Specialists - Omaha
Status: Active
Contact: Gamini S. Soori
Phone: 402-991-8070 Email: mwilwerding@mvcc.cc
Nebraska Methodist Hospital
Status: Active
Contact: Robert M. Langdon
Phone: 402-354-5144
Oncology Hematology West PC
Status: Active
Contact: Gamini S. Soori
Phone: 402-991-8070 Email: mwilwerding@mvcc.cc
Scottsbluff
Regional West Medical Center Cancer Center
Status: Active
Contact: Gamini S. Soori
Phone: 402-991-8070 Email: mwilwerding@mvcc.cc

Nevada

Carson City
Carson Tahoe Regional Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Henderson
21st Century Oncology-Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Status: Active
Contact: John Allan Ellerton
Phone: 702-822-2000
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas Cancer Center-Henderson
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas
21st Century Oncology
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
21st Century Oncology-Fort Apache
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
21st Century Oncology-Vegas Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Ann M Wierman MD LTD
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Shadow
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer and Blood Specialists-Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Cancer Therapy and Integrative Medicine
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Central Valley
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada - Northwest
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Comprehensive Cancer Centers of Nevada-Summerlin
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Centennial Hills
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Maryland Parkway
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-San Martin
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
HealthCare Partners Medical Group Oncology / Hematology-Tenaya
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Las Vegas Cancer Center-Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Nevada Cancer Specialists-Fort Apache
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Radiation Oncology Centers of Nevada Central
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Radiation Oncology Centers of Nevada Southeast
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Summerlin Hospital Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
University Cancer Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
University Medical Center of Southern Nevada
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Pahrump
Hope Cancer Care of Nevada-Pahrump
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Reno
Radiation Oncology Associates
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Renown Regional Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 702-384-0013
Saint Mary's Regional Medical Center
Status: Active
Contact: John Allan Ellerton
Phone: 805-474-9143

New Hampshire

Lebanon
Dartmouth Hitchcock Medical Center
Status: Active
Contact: Alexander David Fuld
Phone: 800-639-6918 Email: cancer.research.nurse@dartmouth.edu
Manchester
Norris Cotton Cancer Center-Manchester
Status: Active
Contact: Alexander David Fuld
Phone: 800-639-6918 Email: cancer.research.nurse@dartmouth.edu
Nashua
Norris Cotton Cancer Center-Nashua
Status: Active
Contact: Alexander David Fuld
Phone: 800-639-6918 Email: cancer.research.nurse@dartmouth.edu

New Jersey

Englewood
Englewood Hospital and Medical Center
Status: Temporarily closed to accrual
Contact: Lewis M. Attas
Phone: 201-894-3456
Newark
Newark Beth Israel Medical Center
Status: Active
Contact: Lori Schleicher
Phone: 973-926-7230
Vineland
Inspira Medical Center Vineland
Status: Active
Contact: Omar Al Ustwani
Phone: 856-641-7933
Woodbury
Inspira Medical Center Woodbury
Status: Active
Contact: Carl J. Minniti
Phone: 856-641-7933

New Mexico

Albuquerque
Lovelace Medical Center-Saint Joseph Square
Status: Active
Contact: Ian Rabinowitz
Phone: 505-272-0530 Email: AYost@nmcca.org
New Mexico Oncology Hematology Consultants
Status: Active
Contact: Ian Rabinowitz
Phone: 505-925-0366 Email: LByatt@nmcca.org
University of New Mexico Cancer Center
Status: Active
Contact: Ian Rabinowitz
Phone: 505-925-0366 Email: LByatt@nmcca.org
Las Cruces
Memorial Medical Center - Las Cruces
Status: Active
Contact: Ian Rabinowitz
Phone: 505-925-0366 Email: LByatt@nmcca.org
Santa Fe
Christus Saint Vincent Regional Cancer Center
Status: Active
Contact: Ian Rabinowitz
Phone: 505-913-8933 Email: Olivia.Sloan@nmcancercare.com

New York

Middletown
Orange Regional Medical Center
Status: Temporarily closed to accrual
Contact: Jeffrey M. Stewart
Phone: 845-342-7609
Rochester
University of Rochester
Status: Temporarily closed to accrual
Contact: Paul Michael Barr
Phone: 585-275-5830
Utica
Faxton-Saint Luke's Healthcare
Status: Active
Contact: Atul V. Butala
Phone: 888-823-5923 Email: ctsucontact@westat.com

North Carolina

Asheville
Asheville Hematology-Oncology Associates
Status: Active
Contact: Raymond Thertulien
Phone: 828-213-4150
Cancer Care of Western North Carolina
Status: Active
Contact: Christopher H. Chay
Phone: 800-506-2550 Email: leslie.verner@msj.org
Mission Hospital-Memorial Campus
Status: Active
Contact: Christopher H. Chay
Phone: 828-213-4150
Clinton
Sampson Radiation Oncology
Status: Temporarily closed to accrual
Contact: James N. Atkins
Phone: 252-399-7491
Southeastern Medical Oncology Center-Clinton
Status: Active
Contact: James N. Atkins
Phone: 252-399-7491
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Status: Active
Contact: James N. Atkins
Phone: 252-399-7491
Wayne Memorial Hospital
Status: Active
Contact: James N. Atkins
Phone: 252-399-7491
Wayne Radiation Oncology
Status: Temporarily closed to accrual
Contact: James N. Atkins
Phone: 252-399-7491
Hendersonville
Hendersonville Hematology and Oncology at Pardee
Status: Active
Contact: James Earl Radford
Phone: 828-696-4716
Margaret R Pardee Memorial Hospital
Status: Active
Contact: James Earl Radford
Phone: 828-696-1341
Park Ridge Health
Status: Active
Contact: Raymond Thertulien
Phone: 828-213-4150
Jacksonville
Onslow Memorial Hospital
Status: Active
Contact: James N. Atkins
Phone: 252-399-7491
Southeastern Medical Oncology Center-Jacksonville
Status: Active
Contact: James N. Atkins
Phone: 252-399-7491
Kinston
Kinston Medical Specialists PA
Status: Active
Contact: Peter Robins Watson
Phone: 252-559-2200
Wilson
Southeastern Medical Oncology Center-Wilson
Status: Temporarily closed to accrual
Contact: James N. Atkins
Phone: 800-849-0203

North Dakota

Bismarck
Sanford Bismarck Medical Center
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Fargo
Roger Maris Cancer Center
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Sanford Broadway Medical Center
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Sanford Clinic North-Fargo
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Grand Forks
Altru Cancer Center
Status: Active
Contact: Grant Richard Seeger
Phone: 855-776-0015
Minot
Trinity Cancer Care Center
Status: Active
Contact: Stephen N.C. Makoni
Phone: 800-862-0005

Ohio

Akron
Cleveland Clinic Akron General
Status: Active
Contact: Esther Hoogland Rehmus
Phone: 330-344-6348
Beavercreek
Indu and Raj Soin Medical Center
Status: Active
Contact: Howard M. Gross
Phone: 937-395-8115
Belpre
Strecker Cancer Center-Belpre
Status: Active
Contact: Timothy David Moore
Phone: 800-523-3977 Email: sheree@columbusccop.org
Canton
Mercy Medical Center
Status: Active
Contact: Mitchell Haut
Phone: 888-293-4673
Centerville
Dayton Physicians LLC-Miami Valley South
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Miami Valley Hospital South
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Chillicothe
Adena Regional Medical Center
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Cincinnati
Oncology Hematology Care Inc - Anderson
Status: Temporarily closed to accrual
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Oncology Hematology Care Inc-Blue Ash
Status: Temporarily closed to accrual
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Oncology Hematology Care Inc-Eden Park
Status: Temporarily closed to accrual
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Oncology Hematology Care Inc-Kenwood
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Oncology Hematology Care Inc-Mercy West
Status: Temporarily closed to accrual
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Columbus
Columbus Oncology and Hematology Associates Inc
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Doctors Hospital
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Grant Medical Center
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Mount Carmel Health Center West
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Riverside Methodist Hospital
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
The Mark H Zangmeister Center
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Dayton
Dayton Physicians LLC-Samaritan North
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Good Samaritan Hospital - Dayton
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Miami Valley Hospital
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Samaritan North Health Center
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Delaware
Delaware Health Center-Grady Cancer Center
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Delaware Radiation Oncology
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Grady Memorial Hospital
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Fairfield
Oncology Hematology Care Inc-Healthplex
Status: Temporarily closed to accrual
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Findlay
Armes Family Cancer Center
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Blanchard Valley Hospital
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Orion Cancer Care
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Franklin
Atrium Medical Center-Middletown Regional Hospital
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Dayton Physicians LLC-Atrium
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Greenville
Dayton Physicians LLC-Wayne
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Wayne Hospital
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Kettering
First Dayton Cancer Care
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Greater Dayton Cancer Center
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Kettering Medical Center
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Lancaster
Fairfield Medical Center
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Marietta
Marietta Memorial Hospital
Status: Active
Contact: Timothy David Moore
Phone: 800-523-3977 Email: sheree@columbusccop.org
Mount Vernon
Knox Community Hospital
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Newark
Licking Memorial Hospital
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Newark Radiation Oncology
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Portsmouth
Southern Ohio Medical Center
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Springfield
Springfield Regional Cancer Center
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Springfield Regional Medical Center
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Sylvania
Flower Hospital
Status: Active
Contact: Abhijit B. Saste
Phone: 419-824-1842
Toledo
The Toledo Hospital / Toledo Children's Hospital
Status: Active
Contact: Abhijit B. Saste
Phone: 419-824-1842
Troy
Dayton Physicians LLC-Upper Valley
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Upper Valley Medical Center
Status: Active
Contact: Howard M. Gross
Phone: 937-775-1350 Email: som_dcop@wright.edu
Westerville
Saint Ann's Hospital
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org
Zanesville
Genesis Healthcare System Cancer Care Center
Status: Active
Contact: Timothy David Moore
Phone: 614-488-2745 Email: sheree@columbusccop.org

Oklahoma

Oklahoma City
Mercy Hospital Oklahoma City
Status: Active
Contact: Jay W. Carlson
Phone: 888-221-4849
University of Oklahoma Health Sciences Center
Status: Active
Contact: Raid Aljumaily
Phone: 405-271-8777 Email: ou-clinical-trials@ouhsc.edu

Oregon

Baker City
Saint Alphonsus Medical Center-Baker City
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Grants Pass
Three Rivers Community Hospital
Status: Active
Contact: Charles Robert Dibb
Phone: 541-789-6176
Medford
Providence Medford Medical Center
Status: Active
Contact: Charles Robert Dibb
Phone: 541-789-6176
Rogue Valley Medical Center
Status: Active
Contact: Charles Robert Dibb
Phone: 541-789-6176
Ontario
Saint Alphonsus Medical Center-Ontario
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Portland
Kaiser Permanente Northwest
Status: Active
Contact: Abdul Hai Mansoor
Phone: 503-335-2400

Pennsylvania

Allentown
Lehigh Valley Hospital-Cedar Crest
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Beaver
UPMC-Heritage Valley Health System Beaver
Status: Active
Contact: James Paul Ohr
Phone: 724-773-7616
Bethlehem
Lehigh Valley Hospital - Muhlenberg
Status: Active
Contact: Philip J. Stella
Phone: 208-367-7954
Ephrata
Ephrata Cancer Center
Status: Active
Contact: Amir Tabatabai
Phone: 877-441-7957
Ephrata Community Hospital
Status: Active
Contact: Amir Tabatabai
Phone: 877-441-7957
Gettysburg
Adams Cancer Center
Status: Active
Contact: Amir Tabatabai
Phone: 877-441-7957
Greensburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Status: Active
Contact: James Paul Ohr
Phone: 724-838-1900
Hanover
Cherry Tree Cancer Center
Status: Active
Contact: Amir Tabatabai
Phone: 877-441-7957
Johnstown
UPMC-Johnstown / John P. Murtha Regional Cancer Center
Status: Active
Contact: James Paul Ohr
Phone: 814-534-4724
Lebanon
Sechler Family Cancer Center
Status: Active
Contact: Amir Tabatabai
Phone: 877-441-7957
McKeesport
UPMC Cancer Center at UPMC McKeesport
Status: Active
Contact: James Paul Ohr
Phone: 412-647-8073
Moon Township
UPMC-Coraopolis / Heritage Valley Radiation Oncology
Status: Active
Contact: James Paul Ohr
Phone: 412-604-2020
Pittsburgh
University of Pittsburgh Cancer Institute (UPCI)
Status: Active
Contact: James Paul Ohr
Phone: 412-647-8073
UPMC-Magee Womens Hospital
Status: Active
Contact: James Paul Ohr
Phone: 412-647-2811
UPMC-Passavant Hospital
Status: Active
Contact: James Paul Ohr
Phone: 412-367-6454
UPMC-Presbyterian Hospital
Status: Active
Contact: James Paul Ohr
Phone: 412-647-2811
UPMC-Saint Clair Hospital Cancer Center
Status: Active
Contact: James Paul Ohr
Phone: 412-502-3920
UPMC-Saint Margaret
Status: Active
Contact: James Paul Ohr
Phone: 412-784-4900
UPMC-Shadyside Hospital
Status: Active
Contact: James Paul Ohr
Phone: 412-621-2334
Reading
Penn State Health Saint Joseph Medical Center
Status: Active
Contact: Marc A. Rovito
Phone: 610-378-2336 Email: danielward2@catholichealth.net
Seneca
UPMC Cancer Center at UPMC Northwest
Status: Active
Contact: James Paul Ohr
Phone: 814-676-7900
Uniontown
UPMC Uniontown Hospital Radiation Oncology
Status: Active
Contact: James Paul Ohr
Phone: 724-437-2503
Washington
UPMC Washington Hospital Radiation Oncology
Status: Active
Contact: James Paul Ohr
Phone: 724-223-3788 Email: cancer@washingtonhospital.org
West Chester
Chester County Hospital
Status: Active
Contact: William Emil Luginbuhl
Phone: 610-431-5297
Williamsport
UPMC Susquehanna
Status: Active
Contact: Warren Lewis Robinson
Phone: 412-647-8073
York
WellSpan Health-York Cancer Center
Status: Active
Contact: Amir Tabatabai
Phone: 877-441-7957
WellSpan Health-York Hospital
Status: Active
Contact: Amir Tabatabai
Phone: 877-441-7957

South Carolina

Easley
Greenville Health System Cancer Institute-Easley
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Florence
McLeod Regional Medical Center
Status: Active
Contact: Rajesh Bajaj
Phone: 843-679-7256
Greenville
Greenville Health System Cancer Institute-Butternut
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Greenville Health System Cancer Institute-Eastside
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Greenville Health System Cancer Institute-Faris
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Greenville Memorial Hospital
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Saint Francis Cancer Center
Status: Active
Contact: Robert D. Siegel
Phone: 864-255-1713
Saint Francis Hospital
Status: Active
Contact: Robert D. Siegel
Phone: 864-255-1713
Greer
Greenville Health System Cancer Institute-Greer
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Seneca
Greenville Health System Cancer Institute-Seneca
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966
Spartanburg
Greenville Health System Cancer Institute-Spartanburg
Status: Active
Contact: Jeffrey Kent Giguere
Phone: 864-679-3966

South Dakota

Sioux Falls
Sanford Cancer Center Oncology Clinic
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088
Sanford USD Medical Center - Sioux Falls
Status: Active
Contact: Preston D. Steen
Phone: 712-252-0088

Tennessee

Bartlett
Boston Baskin Cancer Center-Bartlett
Status: Temporarily closed to accrual
Contact: Raymond Uyiosa Osarogiagbon
Phone: 870-936-7000
Collierville
Integrity Oncology PLLC-Collierville
Status: Temporarily closed to accrual
Contact: Raymond Uyiosa Osarogiagbon
Phone: 870-936-7000
Franklin
Vanderbilt-Ingram Cancer Center Cool Springs
Status: Active
Contact: Leora Horn
Phone: 800-811-8480
Memphis
Baptist Memorial Hospital and Cancer Center-Memphis
Status: Active
Contact: Raymond Uyiosa Osarogiagbon
Phone: 870-936-7000
Baptist Memorial Hospital for Women
Status: Active
Contact: Raymond Uyiosa Osarogiagbon
Phone: 870-936-7000
Family Cancer Center-Memphis
Status: Temporarily closed to accrual
Contact: Raymond Uyiosa Osarogiagbon
Phone: 870-936-7000
Nashville
Vanderbilt Breast Center at One Hundred Oaks
Status: Active
Contact: Leora Horn
Phone: 800-811-8480
Vanderbilt University / Ingram Cancer Center
Status: Active
Contact: Leora Horn
Phone: 800-811-8480

Texas

San Antonio
University of Texas Health Science Center at San Antonio
Status: Active
Contact: Anand Bhasker Karnad
Phone: 518-489-3612 Email: gerryann.currier@usoncology.com

Vermont

Saint Johnsbury
Norris Cotton Cancer Center-North
Status: Active
Contact: Alexander David Fuld
Phone: 800-639-6918 Email: cancer.research.nurse@dartmouth.edu

West Virginia

Huntington
Saint Mary's Medical Center
Status: Active
Contact: Arvinder Singh Bir
Phone: 888-823-5923 Email: ctsucontact@westat.com

Wisconsin

Antigo
Langlade Hospital and Cancer Center
Status: Active
Contact: Harish G. Ahuja
Phone: 877-405-6866
Burlington
Aurora Cancer Care-Southern Lakes VLCC
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Chippewa Falls
Marshfield Clinic-Chippewa Center
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Eau Claire
Marshfield Clinic Cancer Center - Eau Claire
Status: Active
Contact: Bilal H. Naqvi
Phone: 800-924-8515
Marshfield Clinic Cancer Center at Sacred Heart
Status: Temporarily closed to accrual
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Sacred Heart Hospital
Status: Temporarily closed to accrual
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Fond Du Lac
Aurora Health Center-Fond du Lac
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Germantown
Aurora Health Care Germantown Health Center
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Grafton
Aurora Cancer Care-Grafton
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Green Bay
Aurora BayCare Medical Center
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Kenosha
Aurora Cancer Care-Kenosha South
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
La Crosse
Gundersen Lutheran Medical Center
Status: Active
Contact: Kurt Oettel
Phone: 920-433-8889 Email: Christy.Gilchrist@hshs.org
Ladysmith
Marshfield Clinic - Ladysmith Center
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Marinette
Aurora Bay Area Medical Group-Marinette
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Vince Lombardi Cancer Clinic-Marinette
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Marshfield
Marshfield Clinic
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Marshfield Medical Center
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Mequon
Columbia Saint Mary's Hospital - Ozaukee
Status: Active
Contact: Ranveer Nand
Phone: 888-823-5923 Email: ctsucontact@westat.com
Milwaukee
Aurora Cancer Care-Milwaukee
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Aurora Saint Luke's Medical Center
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Aurora Sinai Medical Center
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Columbia Saint Mary's Water Tower Medical Commons
Status: Active
Contact: Ranveer Nand
Phone: 888-823-5923 Email: ctsucontact@westat.com
Minocqua
Marshfield Clinic-Minocqua Center
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
New Richmond
Cancer Center of Western Wisconsin
Status: Active
Contact: David Mark King
Phone: 952-993-1517 Email: mmcorc@healthpartners.com
Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Racine
Aurora Cancer Care-Racine
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Rice Lake
Lakeview Medical Center-Marshfield Clinic
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Marshfield Clinic-Rice Lake Center
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Stevens Point
Ascension Saint Michael's Hospital
Status: Temporarily closed to accrual
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Marshfield Clinic Stevens Point Center
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Saint Michael's Hospital
Status: Temporarily closed to accrual
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Summit
Aurora Medical Center in Summit
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Two Rivers
Vince Lombardi Cancer Clinic-Two Rivers
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Wausau
Aspirus Regional Cancer Center
Status: Active
Contact: Harish G. Ahuja
Phone: 877-405-6866
Marshfield Clinic-Wausau Center
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Wauwatosa
Aurora Cancer Care-Milwaukee West
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
West Allis
Aurora West Allis Medical Center
Status: Active
Contact: Dhimant R. Patel
Phone: 715-735-6523
Weston
Diagnostic and Treatment Center
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Marshfield Clinic - Weston Center
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956
Wisconsin Rapids
Aspirus UW Cancer Center
Status: Active
Contact: Harish G. Ahuja
Phone: 877-405-6866
Marshfield Clinic - Wisconsin Rapids Center
Status: Active
Contact: Bilal H. Naqvi
Phone: 715-717-3956

Wyoming

Cody
Billings Clinic-Cody
Status: Active
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org
Sheridan
Welch Cancer Center
Status: Temporarily closed to accrual
Contact: Benjamin T. Marchello
Phone: 406-969-6060 Email: mccinfo@mtcancer.org

Trial Objectives and Outline

PRIMARY OBJECTIVES:

I. To compare progression-free survival between patients randomized to afatinib dimaleate (afatinib) in combination with cetuximab versus afatinib alone as first-line treatment for EGFR-mutant non-small cell lung cancer (NSCLC).

SECONDARY OBJECTIVES:

I. To evaluate the overall response rate (confirmed and unconfirmed, complete and partial responses) in the subset of patients with measurable disease treated with afatinib plus cetuximab compared to afatinib alone.

II. To assess the safety of each treatment arm when used in the first-line setting.

III. To compare time to treatment failure and time to treatment discontinuation between randomized to afatinib in combination with cetuximab versus afatinib alone.

IV. To compare overall survival (OS) between the arms.

TERTIARY OBJECTIVES:

I. To investigate the molecular mechanisms that confer benefit from afatinib and afatinib plus cetuximab by evaluating whether the presence of de novo EGFR T790M mutation or other molecular alterations in the pre-treatment tumor influence the clinical outcomes.

II. To quantitatively assess whether the ratio of sensitizing EGFR (EGFRs) mutation to EGFR T790M influences outcome and is altered during treatment.

III. To evaluate the frequency of known mechanisms of resistance to EGFR-directed therapies in the context of afatinib plus cetuximab and afatinib alone treatment.

IV. To identify potential novel predictors of benefit to afatinib plus cetuximab.

V. To identify potential new mechanisms of resistance to EGFR-directed therapies.

VI. To establish patient-derived xenografts (PDXs) from a subset of patients by re-biopsy at the time of progressive disease for drug testing and genomic analysis.

VII. To assess whether circulating tumor markers can be used as indicators of sensitivity and resistance to afatinib plus cetuximab and afatinib alone.

VIII. To determine whether the levels of EGFR protein by immunohistochemistry predict for benefit to afatinib plus cetuximab and afatinib alone.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive afatinib dimaleate orally (PO) once daily (QD) on days 1-28 and cetuximab intravenously (IV) over 2 hours on days 1 and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive afatinib dimaleate as in Arm I. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for 3 years.

Trial Phase & Type

Trial Phase

Phase II

Trial Type

Treatment

Lead Organization

Lead Organization
SWOG

Principal Investigator
Sarah B. Goldberg

Trial IDs

Primary ID S1403
Secondary IDs NCI-2014-02405, BI 1200.124
Clinicaltrials.gov ID NCT02438722