Bupropion Hydrochloride in Improving Sexual Desire in Women with Breast or Gynecologic Cancer
- PRIOR TO STEP 1 REGISTRATION
- Score of < 9 on the PHQ-4
- Patients must have a FSFI desire subscale baseline score less than 3.3 * NOTE-Both the PHQ4 and FSFI must be completed by the patient and data entered in Oncology Patient Enrollment Network (OPEN) at Step 1 registration to determine eligibility within 10 days prior to registration; both of these scores will be calculated in the OPEN system once submitted as part of Step 1 registration; an error message will appear once the patient begins Step 2 registration if one or both of the scores make the patient ineligible; in this situation, continue to complete Step 2 with the reason the patient will not continue on the study as “Other” and specify ineligible
- Diagnosis of breast or gynecologic cancer, all types (examples are ductal carcinoma in situ [DCIS], lobular carcinoma in situ[LCIS], invasive breast, ovarian, endometrial, vulvar, cervical and vaginal)
- Completed definitive therapy consisting of surgery, chemotherapy or radiation therapy at least 180 days ago (may continue on Herceptin or endocrine therapy)
- Post-menopausal as defined by at least ONE of the following: * 12 months (365 days) without a period; * Bilateral oophorectomy; * Chemically induced menopause as long as there are no plans to stop during the study; * For women 57 and under, if at least one ovary and woman has had hysterectomy, must have follicle stimulating hormone (FSH) (> 30 mIU/mL) and estradiol in menopausal range per institution’s laboratory (< 10 for ultra sensitive assay: < 25-30 otherwise); (Note: women 58 and older do not have to have hormonal tests) * At least one ovary intact, with a uterus, and 180 days without a period with FSH (> 30 mIU/mL) and estradiol in menopausal range per institution’s laboratory (generally that is < 10 for ultra sensitive assay: < 25-30 otherwise) (Note: women 58 and older do not have to have hormonal tests)
- History, physical and performance status of 2 or less within 180 days prior to registration
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)
- Total bilirubin =< 1.5 x ULN
- Glomerular filtration rate > 60ml/min; OR =< ULN creatinine per institution normals
- For breast cancer patients only, endocrine therapies are allowed (such as aromatase inhibitors, but not current tamoxifen. Prior tamoxifen is permitted with a 30 day wash out period)
- Vaginal estrogen is allowed, for all protocol disease sites, if dose equal to or less than that in estring (< 7.5 mcg) and it has been used for at least 30 days with no plans to stop or alter use during the course of the study
- Antidepressants for mood and hot flashes, including selective serotonin reuptake inhibitors (SSRI’s) will be allowed if patients have been on a stable dose for the last 60 days and the dose is not expected to change during the course of the study; only subthreshold or low dose antidepressants will be allowed, not antidepressants that have been titrated up to the highest doses for depression management (i.e. Effexor 37.5 -75 mg or Lexapro 5-10 mg or Celexa 10 – 20 mg)
- The patient must provide study-specific informed consent prior to study entry/screening
- Women who report that their motivation/desire for sexual intimacy has decreased since her cancer diagnosis
- Able to swallow whole capsules
- Proficient in English (due to number of questionnaires not validated in other languages)
- Completion of the FSFI and PHQ4; both questionnaires will be required and data entered at the time of step 1 registration
- PRIOR TO STEP 2 RANDOMIZATION
- Completion of the following baseline quality of life forms: PHQ4, FSFI, PROMIS sexual function and satisfaction, PROMIS fatigue short form 8a, impact of treatment scale, patient reported outcomes (PRO)-Common Terminology Criteria for Adverse Events (CTCAE) items, and revised dyadic adjustment scale; these quality of life forms will be required and data must be entered in RAVE at step 2 registration; if available at the time of step 1 registration, step 2 registration can take place immediately after step 1, but cannot occur more than 30 days after step 1; women who do not currently have a partner do not have to complete the revised dyadic adjustment scale; enter “no partner” for this form
- Diagnosis of depression, major depressive disorder (MDD), suicidal ideations or anxiety disorders in the past 5 years per the medical chart based on Diagnostic and Statistical Manual (DSM) IV diagnoses
- Seizure disorders
- Current or history of anorexia or bulimia in the past 5 years
- Allergy to bupropion
- Use of drugs metabolized by CYP2D6; these are called CYP2D6 substrates; this is because bupropion is a strong CYP2D6 inhibitor so it will decrease the rate of metabolism of drugs that are CYP2D6 substrates
- Stage IV cancer
- History of Parkinson’s disease, multiple sclerosis or fibromyalgia
- Extensive pelvic exenteration surgery, surgeries which include partial or total vaginectomy with or without reconstruction; radical vulvectomy with or without remove of clitoris
- Women who are currently undergoing or planning to undergo reconstruction surgery during the course of the study; women who have completed reconstruction surgery must be 30 days from surgery
- Oral or transdermal estrogen therapy is not allowed
- Males are not permitted to participate
- Patients undergoing abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs after chronic use
- Patients who discontinue monoamine oxidase (MAO)-inhibitor (I)’s within 14 days prior to starting the investigational drug
- Poorly controlled hypertension (systolic blood pressure [BP] >= 160 mmHg or diastolic BP >= 100 mmHg) on three or more readings in the past 12 months
- Patients with active bipolar disorder
- Patients with impaired decision making as determined by the treating physician
- Concurrent use of bupropion
- Concomitant invasive malignancy requiring treatment other than non-melanomatous skin cancer
- Previous or concurrent use of flibanserin
South San Francisco
West Des Moines
Grosse Pointe Woods
Saint Louis Park
Cape May Court House
Egg Harbor Township
Hilton Head Island
Fond Du Lac
I. Measure the ability of two dose levels of bupropion hydrochloride (bupropion), 150 or 300 mg of extended release, to improve sexual desire more than a placebo at 9 weeks (8 weeks on the target dose) as measured by the desire subscale of the female sexual function index (FSFI).
I. Evaluate the side effects of 150 and 300 mg bupropion extended release and differentiate these side effects from those observed in the placebo arm.
II. Evaluate the effect of 150 and 300 mg of bupropion extended release on the Patient Reported Outcomes Measurement Information System (PROMIS) fatigue scale, PROMIS sexual desire and satisfaction measure, patient health questionnaire (PHQ)-4, and the FSFI total score, at 5 and 9 weeks, as well as the desire subscale score of the FSFI at 5 weeks.
III. Evaluate the effect of 150 and 300 mg of bupropion extended release on the global impression of change scale and the patient’s perception of risk versus (vs.) benefit at 5 weeks (4 weeks at target dose) and 9 weeks (8 weeks at target dose).
OUTLINE: Patients are randomized to 1 of 3 arms.
ARM A: Patients receive bupropion hydrochloride orally (PO) once daily (QD) on days 1-63 and placebo PO QD on days 8-71.
ARM B: Patients receive bupropion hydrochloride PO QD on days 1-7 and 64-71, and twice daily (BID) on days 8-63.
ARM C: Patients receive placebo PO QD on days 1-7 and 64-71, and BID on days 8-63.
Trial Phase Phase II
Trial Type Supportive care
Debra L Barton
- Primary ID NRG-CC004
- Secondary IDs NCI-2017-00344
- Clinicaltrials.gov ID NCT03180294