Repetitive Transcranial Magnetic Stimulation in Promoting Smoking Cessation in Patients with Stage I-IIIA Cancer

PRIMARY OBJECTIVES:

I. To assess a feasibility of the repetitive transcranial magnetic stimulation (rTMS) for smoking cessation in cancer patients.

SECONDARY OBJECTIVES:

I. To obtain preliminary estimates of whether one-week active rTMS of left dorsolateral prefrontal cortex (DLPFC) tends to be more efficacious than sham rTMS during a 7-days of quit attempt laboratory model period increasing abstinence days, and also decreasing cigarette consumption and cue-elicited craving in cancer patients with smoking.

EXPLORATORY OBJECTIVES:

I. Self-reported number of cigarettes smoked per day, cue-induced craving (Questionnaire of Smoking Urges [QSU] – Brief), visual analog scale for craving and side effect will be measured pre and post each rTMS session.

II. Other assessment, Carbon Monoxide, Fagerstrom Test for Nicotine Dependence (FTND), and Minnesota Nicotine Withdrawal Scale (MNWS-R) will be completed at baseline and the last transcranial magnetic stimulation (TMS).

III. FTND, Feasibility metrics will also be tracked, including numbers of complete TMS sessions and dropout rate.

OUTLINE: Participants are randomized to 1 of 2 arms.

ARM I (ACTIVE rTMS): Within a 7-day quit attempt from smoking, patients undergo rTMS daily over 15 minutes for 5 sessions. Patients begin quit attempt after first session.

ARM II (SHAM rTMS): Within a 7-day quit attempt from smoking, patients undergo sham rTMS daily over 15 minutes for 5 sessions. Patients begin quit attempt after first session.

After completion of study, patients will be followed up for 1 month.