Skip to main content

ASP-1929 Photoimmunotherapy (PIT) Study in Recurrent Head / Neck Cancer for Patients Who Have Failed at Least Two Lines of Therapy

Trial Status: Active

A Phase 3, Randomized, Double-Arm, Open-Label, Controlled Trial of ASP-1929 vs Physician's Choice Standard of Care for the Treatment of Locoregional, Recurrent Head and Neck Squamous Cell Carcinoma in Patients Who Have Failed or Progressed On or After at Least Two Lines of Therapy

Inclusion Criteria

  • Have a histologically confirmed locoregional persistent, recurrent or second primary squamous cell carcinoma of the head and neck, not amenable to curative treatment
  • Have failed or progressed on or after at least 2 lines of therapy for squamous cell carcinoma of the head and neck, one of which must be prior systemic platinum-based chemotherapy
  • Have completed prior curative radiation therapy for treatment of their head and neck region
  • Have locoregional head and neck tumor site(s) that are all accessible to illumination
  • Have target tumors that are clearly measurable by contract enhanced CT scan
  • Have a life expectancy of > 6 months, based on Investigator judgment
  • Male participants must agree to use contraception during the treatment period and for at least 6 months after the last ASP-1929 infusion
  • Female patients of childbearing potential must not be pregnant or breastfeeding and agrees to follow the contraceptive guidance during the treatment period and for at least 6 months after the last dose of trial intervention and must refrain from breastfeeding for at least 2 months after the last ASP-1929 infusion
  • Have an Eastern Cooperative Oncology Group (ECOG) score of 0 or 1

Exclusion Criteria

  • Have a history of significant (> Grade 3) cetuximab infusion reactions
  • Have been treated with prior systematic chemotherapy or targeted small molecule therapy or radiation therapy within 2 weeks of trial Day 1 or not recovered from adverse events due to a previously administered agent
  • Have been treated with an anticancer monoclonal antibody therapy within 4 of trial Day 1 or have not recovered from adverse events due to previously administered agent
  • Have been treated with an investigational agent or intervention within 4 weeks of trial Day 1 or have not recovered from adverse events, due to previously administered agent or intervention
  • Have a present history of distant metastatic disease (M1)
  • Have an active undergoing treatment or have a diagnosis of an active cancer other than nonmelanoma skin cancer or HNSCC
  • Have a tumor in enhanced CT or MRI scan invading a major blood vessel, unless the vessel has been embolized, stented or surgically ligated to prevent potential bleeding from a blood vessel
  • Have impaired hepatic function
  • Have impaired renal function
  • Have uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with trial requirements
  • Have been previously treated or randomized to any trial using ASP-1929 or RM-1929 PIT as the study treatment

California

San Francisco
UCSF Medical Center-Mission Bay
Status: WITHDRAWN
Contact: UCSF Clinical Trials
Phone: 877-827-3222

Florida

Miami
University of Miami Miller School of Medicine-Sylvester Cancer Center
Status: ACTIVE

Kentucky

Lexington
University of Kentucky / Markey Cancer Center
Status: ACTIVE

Michigan

Detroit
Wayne State University / Karmanos Cancer Institute
Status: CLOSED_TO_ACCRUAL

Minnesota

Minneapolis
University of Minnesota / Masonic Cancer Center
Status: ACTIVE

Pennsylvania

Philadelphia
Thomas Jefferson University Hospital
Status: TEMPORARILY_CLOSED_TO_ACCRUAL
University of Pennsylvania / Abramson Cancer Center
Status: ACTIVE

Tennessee

Nashville
Vanderbilt University / Ingram Cancer Center
Status: TEMPORARILY_CLOSED_TO_ACCRUAL

Texas

Houston
M D Anderson Cancer Center
Status: ACTIVE

Virginia

Charlottesville
University of Virginia Cancer Center
Status: ACTIVE

The study will have an Experimental Arm and a Control Arm.

Experimental Arm:

Patients may receive repeated ASP-1929 PIT interventions for a period of up to 12 months

after randomization until the patient has complete remission, progressive disease that is no

longer amendable to study treatment, patient experiences intolerable side effects, or patient

discontinues study treatment.

Control Arm:

Patients may be treated with physician's choice SOC until the patient has progressive

disease, patient experiences intolerable side effects, or patient discontinues study

treatment.

Trial Phase Phase III

Trial Type Treatment

Lead Organization
Rakuten Medical, Inc.

  • Primary ID ASP-1929-301
  • Secondary IDs NCI-2019-01324
  • Clinicaltrials.gov ID NCT03769506