Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer

Inclusion Criteria

• Inclusion Criteria: For inclusion in the trial, all of the following inclusion criteria must be fulfilled, as no waivers will be permitted: 1. Provision of signed and dated written informed consent prior to any study specific procedures. Participation in pharmacogenomics testing is optional. 2. Histologically or cytologically confirmed diagnosis of metastatic or locally advanced solid tumor for which no standard therapy is available or standard therapy has failed. 3. Measurable disease on imaging based on RECIST 1.1, except for prostate cancer. 4. Life expectancy of ≥ 3 months and Eastern Cooperative Oncology Group performance status of 0 or 1. 5. Adequate organ and bone marrow reserve function, as indicated by the following laboratory values: 1. Adequate hematological function, defined as absolute neutrophil count ≥ 1.5 × 10^9/liter (L), platelet count ≥ 100 × 10^9/L, and hemoglobin ≥ 8 grams/deciliter without recent transfusion (defined as a transfusion that has occurred within 2 weeks of the hemoglobin measurement). 2. Adequate liver function, defined as total bilirubin level ≤ 1.5 × institutional upper limit of normal (IULN) (except for participants with Gilbert syndrome who must have a total bilirubin level of ≤ 3.0 × IULN), aspartate aminotransferase ≤ 2.5 × IULN, and alanine aminotransferase ≤ 2.5 × IULN. 3. Adequate renal function defined as creatinine ≤ 1.5 × IULN or measured or calculated creatinine clearance ≥ 40 milliliters (mL)/minute per institutional standard. Assessment methods should be recorded. 4. Adequate coagulation, defined as international normalized ratio or prothrombin time ≤ 1.5 × IULN and activated partial thromboplastin time ≤ 1.5 × IULN (unless participant receiving anticoagulant therapy) or stable known coagulopathy with sponsor approval. 6. A sufficient and adequate formalin-fixed paraffin embedded tumor tissue sample (fresh or archival tumor tissue) collected since last treatment and before the first dose from a site not previously irradiated, if clinically feasible. 7. Female participants of childbearing potential must have a negative serum pregnancy test at screening (within 72 hours of first dose of study medication). Non-childbearing potential is defined as 1 of the following: 1. ≥ 45 years of age and has not had menses for > 1 year and there is no alternative medical cause. 2. Amenorrheic for > 2 years without a hysterectomy and/or oophorectomy and follicle stimulating hormone value in the postmenopausal range upon pretrial (screening) evaluation. 3. Status is post-hysterectomy, -oophorectomy, or -tubal ligation. 8. Female participants of childbearing potential must be willing to use highly effective contraceptive measures starting with the Screening visit through 90 days after last dose of study treatment. For the UK only, highly effective contraceptive measures are defined as follows: 1. Combined (estrogen and progesterone containing) hormonal contraception associated with inhibition of ovulation. - Oral - Intravaginal - Transdermal 2. Progesterone-only hormonal contraception associated with inhibition of ovulation. - Oral - Injectable - Implantable 3. Intrauterine device 4. Intrauterine hormone-releasing system 5. Bilateral tubal occlusion 6. Vasectomized partner 7. Sexual abstinence 9. Male participants with a female partner(s) of childbearing potential must agree to use highly effective contraceptive measures throughout the trial starting with the Screening visit through 90 days after the last dose of study treatment is received. Males with pregnant partners must agree to use a condom (which is not considered "highly effective"); no additional method of contraception is required for the pregnant partner. Note: Abstinence is acceptable if this is the established and preferred contraception method for the participant. The following inclusion criteria are in addition to the above criteria. If there are criteria below that differs from above, the below indication-specific criteria take precedence. Additional Inclusion Criteria for Angiosarcoma Cohort 10. Histologically or cytologically confirmed diagnosis of metastatic or locally advanced angiosarcoma for which no standard therapy is available or standard therapy has failed. Additional Inclusion Criteria for the Hepatocellular Cancer (HCC) Cohort 11. Histologically or cytologically confirmed diagnosis or radiological diagnosis following the guidelines from the American Association for the Study of Liver Diseases of metastatic or locally advanced HCC. 12. Must have progressed while receiving, or following, programmed death-ligand 1 (PD(L)-1)-based therapy. 13. Child-Pugh score of A. Note: Participants on anticoagulant treatment would have an assigned value of 1 point when scoring prothrombin time/international normalized ratio so the overall Child-Pugh score is not adversely affected. 14. Adequate organ and bone marrow reserve function as indicated by the following laboratory values: 1. Platelet count ≥ 60 × 10^6/cubic millimeter (mm^3) and absolute neutrophil count ≥ 1,000 × 10^6/L are acceptable provided that the investigator assesses these abnormalities as being due to liver disease. 2. Adequate liver function, defined as aspartate aminotransferase and alanine aminotransferase ≤ 5 × IULN, bilirubin ≤ 2 × IULN. 15. Participants are eligible to enroll if they have non-viral-HCC or if they have hepatitis B (HBV), or hepatitis C virus (HCV) related HCC, defined as follows: 1. Chronic HBV infection as evidenced by detectable HBV surface antigen or HBV DNA. Participants with chronic HBV infection must be on antiviral therapy and have HBV DNA < 500 international units/mL. 2. Active or resolved HCV infection as evidenced by detectable HCV RNA or antibody. Additional Inclusion Criteria for the Non-Small Cell Lung Cancer (NSCLC) Cohort 16. Histologically or cytologically confirmed diagnosis of metastatic or locally advanced NSCLC for which no standard therapy is available or standard therapy has failed: 1. Adenocarcinoma or squamous cell carcinoma at the time of enrollment. If other histologies are also present, must be approved by the medical monitor prior to study entry. 2. For participants without targetable alterations: Prior treatment with anti PD(L)-1-based therapy. 3. Participants with targetable alterations (for example, estimated glomerular filtration rate, anaplastic lymphoma kinase, Kirsten rat sarcoma virus-single point mutation with a glycine-to-cysteine substitution at codon 12, reactive oxygen species, mesenchymal epithelial transition factor receptor, etc.): must have received or be intolerant of at least one approved targeted therapy. Additional Inclusion Criteria for the Prostate Cancer Cohort 17. Diagnosis of metastatic castrate resistant prostate cancer. 18. Must have demonstrated serologic or radiographic progression on or following the most recent therapy in the setting of castrate-level testosterone (< 50 nanograms per mL [ng/mL] and/or maintained on medical/surgical castration throughout) as defined by at least one of the following: 1. Baseline PSA ≥ 2.0 ng/mL and 2 sequential rises in prostate-specific antigen (PSA) with each rising value being at least 1 week apart. 2. Progression by RECIST 1.1. 3. Progression by PCWG3 criteria for bone disease ("2+2" rule) with or without PSA progression. 19. Must maintain castration status defined as serum testosterone < 50 ng/mL. Must be either surgically castrate or on luteinizing hormone-releasing hormone analog for the duration of the study. Additional Inclusion Criteria for Breast Cancer 20. Must have received PD-(L)1 therapy if indicated. Note: Premenopausal participants may continue ongoing ovarian suppression on study. Permitted agents are goserelin, triptorelin or analogs. Exclusion Criteria: For inclusion in the trial, participant must meet none of the following exclusion criteria, as no waivers will be permitted: 1. Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigation device within 3 weeks of first dose of current study drug. 2. Received prior systemic cytotoxic chemotherapy, biological therapy, radiotherapy, or major surgery within 3 weeks prior to first dose of study drug; for tyrosine kinase inhibitor or similar within 4 × half-life prior to first dose of study drug. A 1-week washout is permitted for palliative radiation to non-central nervous system disease, with Sponsor approval. 3. Participants who have received prior CTLA-4 therapy may be enrolled in selected indications upon agreement with the Sponsor. 4. Persistent toxicity of NCI CTCAE version 5.0 Grade > 1 severity that is related to prior therapy. Note: Sensory neuropathy, hypothyroidism or alopecia of Grade ≤ 2 are acceptable. Other Grade 2 toxicities of prior treatments that are controlled with medication (for example, diabetes or hypertension) may be permitted with sponsor approval. 5. Expected to require any other form of systemic or localized antineoplastic therapy while on trial (including maintenance therapy with another agent, radiation therapy, and/or surgical resection). 6. History of: 1. Severe (Grade ≥ 3) hypersensitivity reaction to a fully human monoclonal antibodies 2. Immune-related adverse event requiring treatment with systemic steroids for > 7 days excluding Grade 1 or 2 rash. 3. Interstitial lung disease or lung disease which may interfere with the assessment of pneumonitis. 4. Uncontrolled asthma (that is, ≥ 3 features of partly controlled asthma) 5. Pneumonitis that has required oral or IV corticosteroids. 7. Receiving systemic corticosteroid therapy 1 week prior to the first dose of study drug or receiving any other form of systemic immunosuppressive medication. Note: Corticosteroid use as a premedication for IV contrast allergies/reactions is allowed. Participants who are receiving daily corticosteroid replacement therapy are also an exception to this rule. Daily prednisone at doses of ≤ 7.5 mg or equivalent hydrocortisone dose are examples of permitted replacement therapy. Use of inhaled or topical corticosteroids is permitted. 8. Brain metastases or leptomeningeal metastases with the following exceptions: Note: Brain metastases which have been treated with either surgical resection or stereotactic radio surgery. These participants must be off steroids ≥ 10 days prior to enrollment for the purpose of managing their brain metastases. Repeat brain imaging following surgical resection or stereotactic radiosurgery is not required if their last brain magnetic resonance imaging is within screening window. Note: Untreated isolated brain metastases that are too small for treatment by surgical resection or stereotactic radiosurgery (that is, 1-2 mm) and/or of uncertain etiology are potentially eligible but must be approved by the sponsor. 9. Active or history of autoimmune disease that requires systemic treatment within 2 years of the start of study drug (that is, with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs). Note: Participants with autoimmune conditions requiring hormone replacement therapy or topical treatments are eligible. 10. Has had an allogeneic tissue/solid organ transplant, except for corneal transplants. 11. Active infection requiring systemic treatment. 12. Known history of human immunodeficiency virus type 1 or 2 antibodies. 13. Known active infection with hepatitis B and/or hepatitis C virus. 14. Clinically significant (that is, active) cardiovascular disease: cerebral vascular accident/stroke or myocardial infarction within 6 months of enrollment, unstable angina, congestive heart failure (New York Heart Association class ≥ II), or serious uncontrolled cardiac arrhythmia requiring medication. 15. History or current evidence of any condition, therapy, any active infections, or laboratory abnormality that might confound the results of the trial, interfere with the participant's participation for the full duration of the trial, or is not in the best interest of the participant to participate, in the opinion of the treating Investigator. 16. Known psychiatric or substance abuse disorder that would interfere with cooperation with the requirements of the study. 17. Legally incapacitated or has limited legal capacity. 18. Pregnant or breastfeeding. 19. Concurrent malignancy requiring treatment or history of prior malignancy active within 2 years prior to the first dose of study treatment. Exceptions: participants with completely resected prior early-stage basal/squamous cell skin cancer or treated cervical carcinoma in situ. The following exclusion criteria are in addition to the above criteria. If there are criteria below that differs from above, the below indication-specific criteria take precedence. Additional Exclusion Criteria for the HCC Cohort 20. Received locoregional therapy (for example, transcatheter chemoembolization, radiation, surgery) within 6 weeks or yttrium-90 within 12 weeks. 21. Hepatic encephalopathy within the last 6 months requiring admission or initiation of or intensification of therapy. Participants taking rifaximin/lactulose as encephalopathy prophylaxis are allowed as long as they have not had clinically evident encephalopathy in the past 6 months. 22. Gastro-esophageal varices bleeding in the last 6 months. 23. Ascites requiring paracentesis within the last 3 months. Participants with previous ascites that is managed with stable doses of diuretics and have a Child Pugh score of A are allowed. Exclusion Criterion Specific for the UK 24. Hypersensitivity to the active ingredient or any other component of the investigational medicinal products.