Study of CB-839 (Telaglenastat) in Combination With Talazoparib in Patients With Solid Tumors

Inclusion Criteria

• Inclusion Criteria: (Part 1) -Documented incurable/locally advanced or metastatic solid tumors that have either relapsed or are refractory or intolerant to standard therapies of proven clinical benefit. (Part 2) Meets 1 of the 3 defined cohorts: - Cohort 1: Documented incurable/locally advanced or metastatic ccRCC - Cohort 2: Documented incurable/locally advanced or metastatic defined as ER, PR negative (<1%) and HER2 negative (immunohistochemistry 0 to 1+ or fluorescence in situ hybridization [FISH] negative) - Cohort 3: incurable/locally advanced or metastatic CRC For both Parts 1 & 2: - Recovery to baseline or ≤ Grade 1 Common Terminology Criteria for Adverse Events (CTCAE) v.5.0 from toxicities related to the prior therapy - Adequate renal, hepatic, and hematological function - Per Response Evaluation Criteria in Solid Tumours (RECIST) v1.1 evaluable disease (Part 1) or measurable disease (Part 2) - Ability to provide written consent in accordance with federal, local and institutional guidelines - Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1 Exclusion Criteria for both Parts 1 & 2: - Prior treatment with CB-839 or a PARP inhibitor - Unable to received oral medications - Active and/or untreated central nervous system metastasis. Patients with treated brain metastases must have (1) documented radiographic stability of at least 4 weeks duration demonstrated on baseline central nervous system (CNS) imaging prior to study treatment and (2) be symptomatically stable and off steroids for at least 2 weeks before administration of any study treatment. - Major surgery within 28 days prior to first dose of study drug - Receipt of any anticancer therapy within the following windows: small molecule tyrosine kinase inhibitor therapy (including investigational) within the prior 2 weeks or 5 half-lives prior to C1D1, whichever is longer; any type of anti-cancer antibody or cytotoxic chemotherapy within 4 weeks prior to C1D1; radiation therapy for bone metastasis within 2 weeks prior or any other external radiation therapy within 4 weeks prior to C1D1; patients with clinically relevant ongoing complications from prior radiation therapy are not eligible.