A Study of Multiple Immune and Disease Treatment Combinations in Participants With ER+HER2- Breast Cancer That Has Spread
Trial Status: Active
The hypothesis of the CA048-001 Phase 1 clinical trial is targeting multiple mechanisms involved in generating and maintaining antitumor immune response will lead to a tolerable and robust anti-tumor response. This study utilizes an innovative clinical trial design to determine the safety, tolerability, pharmacodynamic activity and efficacy of targeting multiple, distinct combination regimens that modulate several immune and non-immune mechanisms by escalating the number of therapies administered.
Inclusion Criteria
- Histological and cytological confirmation of adenocarcinoma of the breast
- Documented HER2 negative and estrogen receptor (ER) positive status of primary or metastatic tumor tissue using the most recently assessed tumor specimen, according to the local laboratory parameters
- ER negativity is defined as < 1% of tumor cells expressing hormonal receptors via IHC analysis
- At least one measurable lesion, as per Response Evaluation Criteria in Solid Tumors version 1.1 [RECIST v1.1] that can be accurately assessed at baseline and is suitable for repeated assessment by computed tomography (CT) or magnetic resonance imaging (MRI)
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Women and Men must agree to follow specific methods of contraception, if applicable, while participating in the trial
Exclusion Criteria
- Allergy or hypersensitivity to any study drugs or their excipients
- Any other sound medical, psychiatric and/or social reason as determined by the investigator
- Active, known, or suspected autoimmune disease or immune-related diseases
- History of unstable or deteriorating cardiac disease within the previous 12 months prior to screening
- Prior therapy with anti-programmed death 1 (PD-1), anti-programmed death-ligand 1 (PD-L1) or anti-Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) class antibody
- Any major surgery within 4 weeks of the first dose of study treatment
California
Sacramento
University of California Davis Comprehensive Cancer Center
Status: ACTIVE
Colorado
Aurora
University of Colorado Hospital
Status: ACTIVE
Missouri
Saint Louis
Siteman Cancer Center at Washington University
Status: ACTIVE
New York
New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Status: ACTIVE
Trial Phase Phase I
Trial Type Treatment
Lead Organization
Bristol-Myers Squibb
- Primary ID CA048-001
- Secondary IDs NCI-2020-07235
- Clinicaltrials.gov ID NCT04132817