Skip to main content

Cisplatin and Radiation Therapy with or without Carboplatin and Paclitaxel in Patients with Locally Advanced Cervical Cancer

Trial Status: Closed to Accrual

This randomized phase III trial studies how well giving cisplatin and radiation therapy together with or without carboplatin and paclitaxel works in treating patients with cervical cancer has spread from where it started to nearby tissue or lymph nodes. Drugs used in chemotherapy, such as cisplatin, carboplatin, and paclitaxel, work in different ways to stop the growth of [cancer / tumor] cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. External radiation therapy uses high-energy x rays to kill tumor cells. Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. It is not yet known whether giving cisplatin and external and internal radiation therapy together with carboplatin and paclitaxel kills more tumor cells.

Inclusion Criteria

  • Eligible patients will have locally advanced cervical cancer suitable for primary treatment with chemoradiation with curative intent, in addition to: * Federation of Gynecology and Obstetrics (FIGO) 2008 stage IB1 & node positive, IB2, IIA, IIB, IIIB, or IVA disease
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • Histological diagnosis of squamous cell carcinoma, adenocarcinoma or adenosquamous cell carcinoma of the cervix
  • White blood cells (WBC) >= 3.0 x 10^9/L
  • Absolute neutrophil count (ANC) >= 1.5 x 10^9/L
  • Platelet count >= 100 x 10^9/L
  • Bilirubin =< 1.5 times upper limit of normal (ULN)
  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 x ULN (if both tests are done, both results need to be =< 2.5 x ULN)
  • Creatinine =< ULN (Common Toxicity Criteria [CTC] grade 0) OR calculated creatinine clearance (Cockcroft-Gault formula) >= 60 mL/min OR >= 50 mL/min by ethylenediaminetetraacetic acid (EDTA) creatinine clearance
  • Written informed consent

Exclusion Criteria

  • Any previous pelvic radiotherapy
  • Para-aortic nodal involvement above the level of the common iliac nodes or L3/L4 (if biopsy proven, PET positive, or >= 15 mm short-axis diameter on computed tomography [CT])
  • FIGO 2008 stage IIIA disease
  • Patients assessed at presentation as requiring interstitial brachytherapy treatment
  • Patients with bilateral hydronephrosis unless at least one side has been stented and renal function fulfills the required inclusion criteria
  • Previous chemotherapy for this tumor
  • Evidence of distant metastases
  • Prior diagnosis of Crohn's disease or ulcerative colitis
  • Peripheral neuropathy >= grade 2 (per Common Terminology Criteria for Adverse Events [CTCAE] version [v]4)
  • Patients who have undergone a previous hysterectomy or will have a hysterectomy as part of their initial cervical cancer therapy; this includes patients with a prior history of supracervical hysterectomy
  • Patients with other invasive malignancies, with the exception of non-melanoma skin cancer and in situ melanoma, who had (or have) any evidence of the other cancer present within the last 5 years
  • Patients who are pregnant or lactating
  • Any contraindication to the use of cisplatin, carboplatin, or paclitaxel chemotherapy
  • Serious illness or medical condition that precludes the safe administration of the trial treatment including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Patients who are known to be human immunodeficiency virus (HIV) positive

Alabama

Birmingham
University of Alabama at Birmingham Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Warner King Huh
Phone: 205-934-0309
Mobile
University of South Alabama Mitchell Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Rodney Rocconi
Phone: 251-445-9870

Alaska

Anchorage
Alaska Women's Cancer Care
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin Buckner Bridges
Phone: 208-381-3376
Providence Alaska Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin Buckner Bridges
Phone: 208-381-3376

Arizona

Phoenix
Arizona Oncology Associates-Biltmore Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821
Gynecologic Oncology Group of Arizona
Status: ACTIVE
Contact: Kathleen N. Moore
Phone: 405-271-8707
Saint Joseph's Hospital and Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John Hall Farley
Phone: 877-602-4111
University of Arizona Cancer Center at Saint Joseph's
Status: CLOSED_TO_ACCRUAL
Contact: John Hall Farley
Phone: 877-602-4111
Tucson
Arizona Oncology Associates-West Orange Grove
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821
Arizona Oncology Associates-Wilmot
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821

Arkansas

Little Rock
University of Arkansas for Medical Sciences
Status: CLOSED_TO_ACCRUAL
Contact: Kristin Kelley Zorn
Phone: 501-686-8274

California

Auburn
Sutter Auburn Faith Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Sutter Cancer Centers Radiation Oncology Services-Auburn
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Burlingame
Mills-Peninsula Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Concord
John Muir Medical Center-Concord Campus
Status: CLOSED_TO_ACCRUAL
Contact: Babak Edraki
Phone: 925-674-2580
Davis
Sutter Davis Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Fremont
Kaiser Permanente-Fremont
Status: CLOSED_TO_ACCRUAL
Contact: Tatjana Kolevska
Phone: 626-564-3455
Modesto
Memorial Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Mountain View
Palo Alto Medical Foundation-Camino Division
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Palo Alto Medical Foundation-Gynecologic Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Oakland
Kaiser Permanente-Oakland
Status: CLOSED_TO_ACCRUAL
Contact: Tatjana Kolevska
Phone: 626-564-3455
Orange
Saint Joseph Hospital - Orange
Status: CLOSED_TO_ACCRUAL
Contact: Michael L. Berman
Phone: 877-827-8839
UC Irvine Health / Chao Family Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Krishnansu Sujata Tewari
Phone: 714-456-6191
Palo Alto
Palo Alto Medical Foundation Health Care
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Roseville
Kaiser Permanente-Roseville
Status: CLOSED_TO_ACCRUAL
Contact: Tatjana Kolevska
Phone: 626-564-3455
Sutter Cancer Centers Radiation Oncology Services-Roseville
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Sutter Roseville Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Sacramento
Mercy Cancer Center - Sacramento
Status: CLOSED_TO_ACCRUAL
Contact: Kevin Scott Elliott
Phone: 916-556-3200
Sutter Medical Center Sacramento
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
University of California Davis Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Vanessa A. Kennedy
Phone: 916-734-3089
San Francisco
California Pacific Medical Center-Pacific Campus
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Kaiser Permanente-San Francisco
Status: CLOSED_TO_ACCRUAL
Contact: Tatjana Kolevska
Phone: 626-564-3455
San Rafael
Kaiser Permanente-San Rafael
Status: CLOSED_TO_ACCRUAL
Contact: Tatjana Kolevska
Phone: 626-564-3455
Santa Clara
Kaiser Permanente Medical Center - Santa Clara
Status: CLOSED_TO_ACCRUAL
Contact: Tatjana Kolevska
Phone: 626-564-3455
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Santa Rosa
Sutter Pacific Medical Foundation
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
South San Francisco
Kaiser Permanente-South San Francisco
Status: CLOSED_TO_ACCRUAL
Contact: Tatjana Kolevska
Phone: 626-564-3455
Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Sylmar
Olive View-University of California Los Angeles Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Christine H. Holschneider
Phone: 888-798-0719
Vacaville
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Vallejo
Kaiser Permanente-Vallejo
Status: CLOSED_TO_ACCRUAL
Contact: Tatjana Kolevska
Phone: 626-564-3455
Sutter Solano Medical Center / Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Stacy D. D'Andre
Phone: 415-209-2686
Walnut Creek
John Muir Medical Center-Walnut Creek
Status: CLOSED_TO_ACCRUAL
Contact: Babak Edraki
Phone: 925-674-2580

Colorado

Aurora
Rocky Mountain Cancer Centers-Aurora
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
The Medical Center of Aurora
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
University of Colorado Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Saketh Ram Guntupalli
Phone: 720-848-0650
Boulder
Boulder Community Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Rocky Mountain Cancer Centers-Boulder
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Colorado Springs
Penrose-Saint Francis Healthcare
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Rocky Mountain Cancer Centers-Penrose
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Denver
Colorado Blood Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Porter Adventist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Presbyterian - Saint Lukes Medical Center - Health One
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Rocky Mountain Cancer Centers-Midtown
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Rocky Mountain Cancer Centers-Rose
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Rose Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
SCL Health Saint Joseph Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Western States Cancer Research NCORP
Status: ACTIVE
Contact: Keren Sturtz
Phone: 888-785-6789
Durango
Southwest Oncology PC
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Englewood
Mountain Blue Cancer Care Center - Swedish
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Swedish Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Greeley
North Colorado Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Greenwood Village
Rocky Mountain Cancer Centers-Greenwood Village
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Lakewood
Rocky Mountain Cancer Centers-Lakewood
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Saint Anthony Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Littleton
Littleton Adventist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Rocky Mountain Cancer Centers-Littleton
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Sky Ridge Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Longmont
Longmont United Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Rocky Mountain Cancer Centers-Longmont
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Loveland
McKee Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Parker
Parker Adventist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Rocky Mountain Cancer Centers-Parker
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Pueblo
Rocky Mountain Cancer Centers - Pueblo
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Saint Mary Corwin Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Thornton
Rocky Mountain Cancer Centers-Thornton
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Wheat Ridge
SCL Health Lutheran Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663

Connecticut

Farmington
University of Connecticut
Status: CLOSED_TO_ACCRUAL
Contact: Angela S. Kueck
Phone: 800-579-7822
Hartford
Hartford Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Amy Kirkpatrick Brown
Phone: 860-545-5363
New Britain
The Hospital of Central Connecticut
Status: CLOSED_TO_ACCRUAL
Contact: Amy Kirkpatrick Brown
Phone: 860-545-5363
New Haven
Yale University
Status: CLOSED_TO_ACCRUAL
Contact: Peter Edward Schwartz
Phone: 203-785-5702

Delaware

Newark
Christiana Care Health System-Christiana Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mark Eliot Borowsky
Phone: 302-733-6227

Florida

Deerfield Beach
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Status: CLOSED_TO_ACCRUAL
Contact: Aaron H. Wolfson
Phone: 305-243-2647
Gainesville
University of Florida Health Science Center - Gainesville
Status: CLOSED_TO_ACCRUAL
Contact: Merry Jennifer Markham
Phone: 352-273-8675
Miami
Jackson Memorial Hospital-Holtz Children's Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Aaron H. Wolfson
Phone: 305-243-2647
University of Miami Miller School of Medicine-Sylvester Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Aaron H. Wolfson
Phone: 305-243-2647
Orlando
UF Cancer Center at Orlando Health
Status: ACTIVE
Contact: Kathleen N. Moore
Phone: 405-271-4272
Sarasota
Sarasota Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James Vincent Fiorica
Phone: 941-917-2225

Georgia

Atlanta
Emory University Hospital / Winship Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Joseph William Shelton
Phone: 404-778-1868
Emory University Hospital Midtown
Status: CLOSED_TO_ACCRUAL
Contact: Joseph William Shelton
Phone: 404-778-1868
Grady Health System
Status: CLOSED_TO_ACCRUAL
Contact: Joseph William Shelton
Phone: 404-778-1868
Northside Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Daniel Shasha
Phone: 412-339-5294
Gainesville
Northeast Georgia Medical Center-Gainesville
Status: CLOSED_TO_ACCRUAL
Contact: Andrew Emmons Green
Phone: 770-219-8800
Macon
Central Georgia Gynecologic Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Gary Lee Eddy
Phone: 478-633-6090

Hawaii

Aiea
The Cancer Center of Hawaii-Pali Momi
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-983-6090
Honolulu
Kaiser Permanente Moanalua Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Tatjana Kolevska
Phone: 626-564-3455
Kapiolani Medical Center for Women and Children
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-983-6090
Queen's Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-983-6090
The Cancer Center of Hawaii-Liliha
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-983-6090
University of Hawaii Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-983-6090

Idaho

Boise
Saint Alphonsus Cancer Care Center-Boise
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 208-367-7954
Saint Luke's Mountain States Tumor Institute
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin Buckner Bridges
Phone: 208-381-3376
Coeur D'Alene
Kootenai Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Fruitland
Saint Luke's Mountain States Tumor Institute - Fruitland
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin Buckner Bridges
Phone: 208-381-3376
Meridian
Saint Luke's Mountain States Tumor Institute - Meridian
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin Buckner Bridges
Phone: 208-381-3376
Nampa
Saint Luke's Mountain States Tumor Institute - Nampa
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin Buckner Bridges
Phone: 208-381-3376
Post Falls
Kootenai Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Sandpoint
Kootenai Cancer Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Twin Falls
Saint Luke's Mountain States Tumor Institute-Twin Falls
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin Buckner Bridges
Phone: 208-381-3376

Illinois

Bloomington
Illinois CancerCare-Bloomington
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Saint Joseph Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Canton
Illinois CancerCare-Canton
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Carthage
Illinois CancerCare-Carthage
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Centralia
Centralia Oncology Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Chicago
John H Stroger Jr Hospital of Cook County
Status: CLOSED_TO_ACCRUAL
Contact: Thomas E. Lad
Phone: 312-864-6000
Northwestern University
Status: CLOSED_TO_ACCRUAL
Contact: Eric D. Donnelly
Phone: 312-695-1301
Rush University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Summer B. Dewdney
Phone: 312-942-5498
University of Chicago Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: John William Moroney
Phone: 773-834-7424
Decatur
Cancer Care Specialists of Illinois - Decatur
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Decatur Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Effingham
Crossroads Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Eureka
Illinois CancerCare-Eureka
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Evanston
NorthShore University HealthSystem-Evanston Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Moore
Phone: 847-570-2109
Galesburg
Illinois CancerCare-Galesburg
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Western Illinois Cancer Treatment Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Geneva
Northwestern Medicine Cancer Center Delnor
Status: CLOSED_TO_ACCRUAL
Contact: LaToya J. Perry
Phone: 630-315-1918
Glenview
NorthShore University HealthSystem-Glenbrook Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Moore
Phone: 847-570-2109
Highland Park
NorthShore University HealthSystem-Highland Park Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Moore
Phone: 847-570-2109
Hinsdale
Sudarshan K Sharma MD Limited-Gynecologic Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Sudarshan K. Sharma
Phone: 630-856-6757
Kewanee
Illinois CancerCare-Kewanee Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Macomb
Illinois CancerCare-Macomb
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Maywood
Loyola University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: William Small
Phone: 708-226-4357
Ottawa
Illinois CancerCare-Ottawa Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Pekin
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Peoria
Illinois CancerCare-Peoria
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Methodist Medical Center of Illinois
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
OSF Saint Francis Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Peru
Illinois CancerCare-Peru
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Valley Radiation Oncology
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Princeton
Illinois CancerCare-Princeton
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Springfield
Memorial Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Southern Illinois University School of Medicine
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Springfield Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Warrenville
Northwestern Medicine Cancer Center Warrenville
Status: CLOSED_TO_ACCRUAL
Contact: LaToya J. Perry
Phone: 630-315-1918

Indiana

Elkhart
Michiana Hematology Oncology PC-Elkhart
Status: ACTIVE
Contact: Kathleen N. Moore
Phone: 405-271-4272
Indianapolis
Indiana University / Melvin and Bren Simon Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Frederick B. Stehman
Phone: 317-274-2552
Saint Vincent Hospital and Health Care Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael J. Callahan
Phone: 317-338-2194
Mishawaka
Michiana Hematology Oncology PC-Mishawaka
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen N. Moore
Saint Joseph Regional Medical Center-Mishawaka
Status: ACTIVE
Contact: Kathleen N. Moore
Phone: 405-271-4272
Munster
The Community Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mohamad Kassar
Phone: 219-836-3349

Iowa

Iowa City
University of Iowa / Holden Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: David Paul Bender
Phone: 800-237-1225

Kansas

Kansas City
University of Kansas Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Julia Ann Chapman
Phone: 913-945-7552

Kentucky

Lexington
Baptist Health Lexington
Status: CLOSED_TO_ACCRUAL
Contact: Hope Cottrill
Phone: 859-260-6425
University of Kentucky / Markey Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Frederick Rand Ueland
Phone: 859-257-3379
Louisville
Norton Brownsboro Hospital and Medical Campus
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen N. Moore
Norton Hospital Pavilion and Medical Campus
Status: CLOSED_TO_ACCRUAL
Contact: Mary Evelyn Gordinier
Phone: 502-629-2500

Louisiana

Baton Rouge
Woman's Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Milton Giles Fort
Phone: 225-231-5296
New Orleans
Louisiana State University Health Science Center
Status: CLOSED_TO_ACCRUAL
Contact: Augusto C. Ochoa
Phone: 504-568-2428
Ochsner Medical Center Jefferson
Status: CLOSED_TO_ACCRUAL
Contact: Richard Carl Kline
Phone: 888-562-4763
Tulane University Health Sciences Center
Status: CLOSED_TO_ACCRUAL
Contact: William Russell Robinson
Phone: 504-988-6121
University Medical Center New Orleans
Status: CLOSED_TO_ACCRUAL
Contact: Augusto C. Ochoa
Phone: 504-568-2428

Maine

Portland
Maine Medical Center-Bramhall Campus
Status: CLOSED_TO_ACCRUAL
Contact: Christopher J. Darus
Phone: 207-885-7565
Scarborough
Maine Medical Center- Scarborough Campus
Status: CLOSED_TO_ACCRUAL
Contact: Christopher J. Darus
Phone: 207-885-7565

Maryland

Baltimore
University of Maryland / Greenebaum Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Gautam Gorantla Rao
Phone: 800-888-8823
Bethesda
Walter Reed National Military Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: William J. Lowery
Phone: 301-319-2100

Massachusetts

Springfield
Baystate Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James S. Hoffman
Phone: 413-794-3565
Worcester
UMass Memorial Medical Center - Memorial Division
Status: CLOSED_TO_ACCRUAL
Contact: Susan Lee Zweizig
Phone: 508-856-3216

Michigan

Ann Arbor
Saint Joseph Mercy Hospital
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 208-367-7954
Battle Creek
Bronson Battle Creek
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Detroit
Henry Ford Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Thomas E. Buekers
Phone: 313-916-1784
Wayne State University / Karmanos Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Robert Thomas Morris
Phone: 313-576-9363
Grand Rapids
Cancer Research Consortium of West Michigan NCORP
Status: ADMINISTRATIVELY_COMPLETE
Contact: Gilbert D.A. Padula
Phone: 616-685-5225
Mercy Health Saint Mary's
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Spectrum Health at Butterworth Campus
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Kalamazoo
West Michigan Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Lansing
Sparrow Hospital
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 208-367-7954
Royal Oak
William Beaumont Hospital-Royal Oak
Status: CLOSED_TO_ACCRUAL
Contact: Jayson Bert Field
Phone: 248-551-7695
Traverse City
Munson Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230

Minnesota

Coon Rapids
Mercy Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Matthew P. Boente
Phone: 952-993-1517
Edina
Fairview-Southdale Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Matthew P. Boente
Phone: 952-993-1517
Minneapolis
Abbott-Northwestern Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Matthew P. Boente
Phone: 952-993-1517
University of Minnesota / Masonic Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Peter Alexander Argenta
Phone: 612-624-2620
Saint Paul
United Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Matthew P. Boente
Phone: 952-993-1517
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Status: CLOSED_TO_ACCRUAL
Contact: Matthew P. Boente
Phone: 952-993-1517

Mississippi

Jackson
University of Mississippi Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Kelly Jeanes Wilkinson
Phone: 601-815-6700

Missouri

Springfield
CoxHealth South Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532
Mercy Hospital Springfield
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 800-821-7532

Montana

Billings
Billings Clinic Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Saint Vincent Healthcare
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Bozeman
Bozeman Deaconess Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Butte
Saint James Community Hospital and Cancer Treatment Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Great Falls
Benefis Healthcare- Sletten Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Helena
Saint Peter's Community Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Kalispell
Kalispell Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Missoula
Saint Patrick Hospital - Community Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin Buckner Bridges
Phone: 208-381-3376

Nebraska

Omaha
Nebraska Methodist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Peter Craig Morris
Phone: 402-354-7939
University of Nebraska Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Kerry Julene Rodabaugh
Phone: 402-559-6941

Nevada

Las Vegas
Women's Cancer Center of Nevada
Status: CLOSED_TO_ACCRUAL
Contact: Nicola M. Spirtos
Phone: 702-851-4672

New Hampshire

Dover
Wentworth-Douglass Hospital
Status: CLOSED_TO_ACCRUAL
Contact: John Orland Schorge
Phone: 877-726-5130

New Jersey

Basking Ridge
Memorial Sloan Kettering Basking Ridge
Status: CLOSED_TO_ACCRUAL
Contact: Mario Mendes Leitao
Phone: 212-639-7202
Camden
Cooper Hospital University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: David Philip Warshal
Phone: 856-325-6757
Hackensack
Hackensack University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Donna M. McNamara
Phone: 201-996-2879
Morristown
Morristown Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Yana Pavel Goldberg
Phone: 973-971-5900
Mount Holly
Virtua Memorial
Status: CLOSED_TO_ACCRUAL
Contact: Randolph Bruce Deger
Phone: 609-914-6762
Neptune
Jersey Shore Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Karim Samir ElSahwi
Phone: 732-776-4240
New Brunswick
Rutgers Cancer Institute of New Jersey
Status: CLOSED_TO_ACCRUAL
Contact: Darlene Grace Gibbon
Phone: 732-235-8675
Voorhees
MD Anderson Cancer Center at Cooper-Voorhees
Status: CLOSED_TO_ACCRUAL
Contact: David Philip Warshal
Phone: 856-325-6757

New Mexico

Albuquerque
Lovelace Radiation Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Teresa L. Rutledge
Phone: 505-925-0366
Southwest Gynecologic Oncology Associates Inc
Status: CLOSED_TO_ACCRUAL
Contact: Teresa L. Rutledge
Phone: 505-925-0366
University of New Mexico Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Teresa L. Rutledge
Phone: 505-925-0366
Las Cruces
Memorial Medical Center - Las Cruces
Status: CLOSED_TO_ACCRUAL
Contact: Teresa L. Rutledge
Phone: 505-925-0366

New York

Albany
Women's Cancer Care Associates LLC
Status: CLOSED_TO_ACCRUAL
Contact: Joyce Nuqui Barlin
Phone: 518-458-1390
Bronx
Montefiore Medical Center-Einstein Campus
Status: CLOSED_TO_ACCRUAL
Contact: Gary L. Goldberg
Phone: 516-562-3467
Brooklyn
New York-Presbyterian / Brooklyn Methodist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Katherine Economos
Phone: 718-780-3677
State University of New York Downstate Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Ovadia Abulafia
Phone: 718-613-8324
Buffalo
Roswell Park Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Peter Jonathan Frederick
Phone: 877-275-7724
Commack
Memorial Sloan Kettering Commack
Status: CLOSED_TO_ACCRUAL
Contact: Mario Mendes Leitao
Phone: 212-639-7202
Fresh Meadows
The New York Hospital Medical Center of Queens
Status: CLOSED_TO_ACCRUAL
Contact: Manolis T. Tsatsas
Phone: 888-823-5923
Jamaica
Queens Hospital Center
Status: CLOSED_TO_ACCRUAL
Contact: Mary Margaret Kemeny
Phone: 718-883-3000
Lake Success
Northwell Health / Center for Advanced Medicine
Status: CLOSED_TO_ACCRUAL
Contact: Veena Susan John
Phone: 516-734-8954
Manhasset
North Shore University Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Veena Susan John
Phone: 516-734-8954
Mineola
NYU Winthrop Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Eva Chalas
Phone: 866-946-8476
New Hyde Park
Long Island Jewish Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Veena Susan John
Phone: 516-734-8954
New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Status: CLOSED_TO_ACCRUAL
Contact: Leslie R. Boyd
Phone: 212-263-4434
Lenox Hill Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Veena Susan John
Phone: 516-734-8954
Memorial Sloan Kettering Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Mario Mendes Leitao
Phone: 212-639-7202
Rochester
Highland Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Richard G. Moore
Phone: 585-275-5830
University of Rochester
Status: CLOSED_TO_ACCRUAL
Contact: Richard G. Moore
Phone: 585-275-5830
Sleepy Hollow
Memorial Sloan Kettering Sleepy Hollow
Status: CLOSED_TO_ACCRUAL
Contact: Mario Mendes Leitao
Phone: 212-639-7202
Stony Brook
Stony Brook University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael L. Pearl
Phone: 800-862-2215
Uniondale
Memorial Sloan Kettering Nassau
Status: CLOSED_TO_ACCRUAL
Contact: Mario Mendes Leitao
Phone: 212-639-7202
West Harrison
Memorial Sloan Kettering Westchester
Status: CLOSED_TO_ACCRUAL
Contact: Mario Mendes Leitao
Phone: 212-639-7202

North Carolina

Burlington
Cone Health Cancer Center at Alamance Regional
Status: CLOSED_TO_ACCRUAL
Contact: Vinay K. Gudena
Phone: 336-832-0821
Chapel Hill
UNC Lineberger Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Linda Van Le
Phone: 877-668-0683
Charlotte
Carolinas Medical Center / Levine Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Robert Victor Higgins
Phone: 704-355-2884
Concord
Atrium Health Cabarrus / LCI-Concord
Status: CLOSED_TO_ACCRUAL
Contact: Robert Victor Higgins
Phone: 704-355-2884
Wilmington
New Hanover Regional Medical Center / Zimmer Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Walter H. Gajewski
Phone: 910-342-3000
Winston-Salem
Southeast Clinical Oncology Research Consortium NCORP
Status: TEMPORARILY_CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 864-512-1000
Wake Forest University Health Sciences
Status: CLOSED_TO_ACCRUAL
Contact: Samuel Smith Lentz
Phone: 336-713-6771

Ohio

Akron
Summa Health System - Akron Campus
Status: CLOSED_TO_ACCRUAL
Contact: Stephen J. Andrews
Phone: 330-375-6101
Cincinnati
University of Cincinnati / Barrett Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Eric Lawrence Eisenhauer
Phone: 513-558-4553
Cleveland
Case Western Reserve University
Status: CLOSED_TO_ACCRUAL
Contact: Steven E. Waggoner
Phone: 800-641-2422
Cleveland Clinic Cancer Center / Fairview Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Peter G. Rose
Phone: 866-223-8100
Cleveland Clinic Foundation
Status: CLOSED_TO_ACCRUAL
Contact: Peter G. Rose
Phone: 866-223-8100
MetroHealth Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Peter G. Rose
Phone: 866-223-8100
Columbus
Ohio State University Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: David M. O'Malley
Phone: 800-293-5066
Riverside Methodist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-488-2745
Dayton
Miami Valley Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Kettering
Kettering Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Mayfield Heights
Hillcrest Hospital Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Peter G. Rose
Phone: 866-223-8100
Mentor
UH Seidman Cancer Center at Lake Health Mentor Campus
Status: CLOSED_TO_ACCRUAL
Contact: Steven E. Waggoner
Phone: 800-641-2422
Toledo
University of Toledo
Status: CLOSED_TO_ACCRUAL
Contact: Rex B. Mowat
Phone: 800-444-3561
WPAFB
Wright-Patterson Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350

Oklahoma

Oklahoma City
University of Oklahoma Health Sciences Center
Status: CLOSED_TO_ACCRUAL
Contact: Robert S. Mannel
Phone: 405-271-8777
Tulsa
Oklahoma Cancer Specialists and Research Institute-Tulsa
Status: CLOSED_TO_ACCRUAL
Contact: Robert S. Mannel
Phone: 405-271-8777

Oregon

Portland
Providence Portland Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin Buckner Bridges
Phone: 208-381-3376

Pennsylvania

Abington
Abington Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Joel I. Sorosky
Phone: 215-481-2402
Bethlehem
Saint Luke's University Hospital-Bethlehem Campus
Status: CLOSED_TO_ACCRUAL
Contact: Nicholas P. Taylor
Phone: 610-954-3582
Philadelphia
Drexel University School of Medicine
Status: CLOSED_TO_ACCRUAL
Contact: Scott Daniel Richard
Phone: 866-884-4484
Thomas Jefferson University Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Pramila Rani Anne
Phone: 215-955-6084
University of Pennsylvania / Abramson Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Robert Allen Burger
Phone: 215-746-7406
Pittsburgh
UPMC-Magee Womens Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Dwight Earl Heron
Phone: 412-623-1275
UPMC-Shadyside Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Dwight Earl Heron
Phone: 412-623-1275
West Penn Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Thomas Carl Krivak
Phone: 412-578-5000
West Reading
Reading Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Bernice L. Robinson-Bennett
Phone: 610-988-9323

Rhode Island

Providence
Women and Infants Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Paul A. DiSilvestro
Phone: 401-274-1122

South Carolina

Anderson
AnMed Health Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 864-512-1000
Charleston
Medical University of South Carolina
Status: CLOSED_TO_ACCRUAL
Contact: Jennifer L. Young Pierce
Phone: 843-792-9321
Gaffney
Gibbs Cancer Center-Gaffney
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 864-512-1000
Greenville
Saint Francis Hospital
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 864-512-1000
Greer
Gibbs Cancer Center-Pelham
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 864-512-1000
Spartanburg
Spartanburg Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 864-512-1000
Union
MGC Hematology Oncology-Union
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 864-512-1000

South Dakota

Rapid City
Black Hills Obstetrics and Gynecology
Status: CLOSED_TO_ACCRUAL
Contact: Helen L. Frederickson
Phone: 605-716-3982
Rapid City Regional Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Michael O. Robinson
Phone: 605-716-3982

Texas

Austin
Texas Oncology - Central Austin Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821
Texas Oncology - South Austin Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821
Texas Oncology-Austin Midtown
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821
Bedford
Texas Oncology Bedford
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821
Dallas
Texas Oncology at Baylor Charles A Sammons Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821
UT Southwestern / Simmons Cancer Center-Dallas
Status: CLOSED_TO_ACCRUAL
Contact: David Scott Miller
Phone: 214-648-7097
Fort Worth
Texas Oncology - Fort Worth Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821
Galveston
University of Texas Medical Branch
Status: CLOSED_TO_ACCRUAL
Contact: Lyuba Levine
Phone: 409-772-1950
Houston
Houston Methodist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Aparna A. Kamat
Phone: 713-790-2700
Lyndon Baines Johnson General Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Lois M. Ramondetta
Phone: 713-792-3245
M D Anderson Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Lois M. Ramondetta
Phone: 713-792-3245
Memorial Hermann Texas Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Joseph Anthony Lucci
Phone: 713-792-3245
Odessa
West Texas Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821
Sugar Land
Houston Methodist Sugar Land Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Aparna A. Kamat
Phone: 713-790-2700

Utah

Murray
Intermountain Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Saint George
Dixie Medical Center Regional Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Salt Lake City
Huntsman Cancer Institute / University of Utah
Status: CLOSED_TO_ACCRUAL
Contact: Matthew M. Poppe
Phone: 801-581-4477
LDS Hospital
Status: CLOSED_TO_ACCRUAL
Contact: R. Jeffrey Lee
Phone: 801-507-3950
Utah Cancer Specialists-Salt Lake City
Status: CLOSED_TO_ACCRUAL
Contact: R. Jeffrey Lee
Phone: 801-507-3950

Virginia

Charlottesville
University of Virginia Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Susan Carnall Modesitt
Phone: 434-243-6322
Richmond
Virginia Commonwealth University / Massey Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Emma Charlotte Fields
Phone: 804-628-1939
Roanoke
Carilion Clinic Gynecological Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Janet L. Osborne
Phone: 540-985-8510

Washington

Auburn
MultiCare Auburn Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Gig Harbor
MultiCare Gig Harbor Medical Park
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Puyallup
MultiCare Good Samaritan Hospital
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394
Tacoma
MultiCare Tacoma General Hospital
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 253-403-2394

Wisconsin

Green Bay
Aurora BayCare Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Ali Mahdavi
Phone: 800-928-1103
Madison
University of Wisconsin Hospital and Clinics
Status: CLOSED_TO_ACCRUAL
Contact: Kristin A. Bradley
Phone: 877-405-6866
Milwaukee
Aurora Saint Luke's Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Ali Mahdavi
Phone: 800-928-1103
Medical College of Wisconsin
Status: CLOSED_TO_ACCRUAL
Contact: William H. Bradley
Phone: 414-805-4380
Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh
Status: CLOSED_TO_ACCRUAL
Contact: Ali Mahdavi
Phone: 800-928-1103
Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Status: CLOSED_TO_ACCRUAL
West Allis
Aurora West Allis Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Ali Mahdavi
Phone: 800-928-1103

Wyoming

Cheyenne
Cheyenne Regional Medical Center-West
Status: CLOSED_TO_ACCRUAL
Contact: Keren Sturtz
Phone: 303-777-2663
Cody
Billings Clinic-Cody
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274
Sheridan
Welch Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-648-6274

Ontario

Hamilton
Juravinski Cancer Centre at Hamilton Health Sciences
Status: CLOSED_TO_ACCRUAL
Contact: Lorraine (Laurie) M. Elit
Phone: 905-387-9495
London
London Regional Cancer Program
Status: CLOSED_TO_ACCRUAL
Contact: David Paul D'Souza
Phone: 519-685-8600
Toronto
University Health Network-Princess Margaret Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Anthony William Fyles
Phone: 416-946-4501

Quebec

Montreal
CHUM - Centre Hospitalier de l'Universite de Montreal
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen N. Moore
CHUM - Hopital Notre-Dame
Status: CLOSED_TO_ACCRUAL
Contact: Maroie Barkati
Phone: 514-890-8000ext23611
McGill University Department of Oncology
Status: ACTIVE
Contact: Joanne Alfieri
Phone: 514-934-1934extn42953
The Research Institute of the McGill University Health Centre (MUHC)
Status: CLOSED_TO_ACCRUAL
Contact: Joanne Alfieri
Phone: 514-934-1934ext42953

Saskatchewan

Regina
Allan Blair Cancer Centre
Status: CLOSED_TO_ACCRUAL
Contact: Evgeny Sadikov
Phone: 306-766-2213

China

Guangdong Province
Zhongshan Hospital Fudan University
Status: CLOSED_TO_ACCRUAL
Contact: Xiaohua Wu
Phone: (8621) 64175590 X 81112

Saudi Arabia

Riyadh
King Faisal Specialist Hospital and Research Centre
Status: CLOSED_TO_ACCRUAL
Contact: Hamed Homoud Al-Husaini
Phone: 011-966-1-464-7272 ext 38005

Singapore

Singapore
National University Hospital Singapore
Status: CLOSED_TO_ACCRUAL
Contact: Lim Yi Wan

PRIMARY OBJECTIVES:

I. To determine if the addition of adjuvant chemotherapy to standard cisplatin-based chemoradiation improves overall survival.

SECONDARY OBJECTIVES:

I. To determine the progression-free survival rates.

II. To determine acute and long-term toxicities.

III. To determine patterns of disease recurrence.

IV. To determine the association between radiation protocol compliance and outcomes.

V. To determine patient quality of life, including psycho-sexual health.

TERTIARY OBJECTIVES:

I. To determine the association between the results of a follow-up positron emission tomography (PET) scan performed 4–6 months post completion of chemoradiation and outcomes for all patients in the trial.

II. To determine the biological predictors of patients' outcomes based on translational laboratory studies of blood and tissue specimens.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive cisplatin intravenously (IV) over 60-90 minutes on days 1, 8, 15, 22, and 29. Patients also undergo external-beam radiation therapy once daily, 5 days a week, for approximately 5 weeks. Patients then undergo high-dose rate, pulsed-dose rate, or low-dose rate intracavitary brachytherapy.

ARM II: Patients receive cisplatin and undergo external-beam radiation and brachytherapy as in arm I. Beginning 4 weeks later, patients also receive adjuvant chemotherapy comprising paclitaxel IV over 3 hours and carboplatin IV over 1 hour on day 1. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.

Patients may undergo baseline tumor biopsy and blood collection for future correlative studies.

Patients complete the European Organization for Research and Treatment of Cancer (EORTC) Core questionnaire (QLQ-C30), the EORTC cervix cancer module (CX24), the ovarian cancer module (OV28), and the Sexual function-Vaginal Changes Questionnaire (SVQ) questionnaires at baseline, during, and after completion of study treatment.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Trial Phase Phase III

Trial Type Treatment

Lead Organization
NRG Oncology

Principal Investigator
Kathleen N. Moore

  • Primary ID ANZGOG-0902-GOG-0274
  • Secondary IDs NCI-2011-02978, ANZGOG-0902/GOG-0274/RTOG-1174, CDR0000706698, GOG-0274, RTOG-1174, ANZGOG-0902, S12-01864
  • Clinicaltrials.gov ID NCT01414608