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Paclitaxel and Carboplatin with or without Metformin Hydrochloride in Treating Patients with Stage III, IV, or Recurrent Endometrial Cancer

Trial Status: Closed to Accrual

This randomized phase II / III trial studies how well paclitaxel, carboplatin, and metformin hydrochloride works and compares it to paclitaxel, carboplatin, and placebo in treating patients with endometrial cancer that is stage III, IV, or has come back. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Metformin hydrochloride may help paclitaxel and carboplatin work better by making cancer cells more sensitive to the drugs. It is not yet known whether paclitaxel and carboplatin is more effective with or without metformin hydrochloride in treating endometrial cancer.

Inclusion Criteria

  • Patients must have measurable stage III, measurable stage IVA, stage IVB (with or without measurable disease) or recurrent (with or without measurable disease) endometrial carcinoma * Histologic confirmation of the original primary tumor is required; patients with the following histologic epithelial cell types are eligible: ** Endometrioid adenocarcinoma, serous adenocarcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, mixed epithelial carcinoma, adenocarcinoma not otherwise specified (N.O.S.)
  • Measurable disease is defined by Response Evaluation Criteria in Solid Tumors (RECIST) (version 1.1); measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded); each lesion must be >= 10 mm when measured by computed tomography (CT), magnetic resonance imaging (MRI) or caliper measurement by clinical exam; or >= 20 mm when measured by chest x-ray; lymph nodes must be >= 15 mm in short axis when measured by CT or MRI
  • Patients must have a Gynecologic Oncology Group (GOG) performance status of 0, 1, or 2
  • Absolute neutrophil count (ANC) greater than or equal to 1,500/mcl
  • Platelets greater than or equal to 100,000/mcl
  • Creatinine less than 1.4 mg/dl
  • Bilirubin less than or equal to 1.5 x institutional/laboratory upper limit of normal (ULN)
  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 3 x ULN
  • Alkaline phosphatase less than or equal to 2.5 x ULN
  • Patients must NOT have received prior chemotherapy or targeted therapy, including chemotherapy used for radiation sensitization for treatment of endometrial carcinoma
  • Patients may have received prior radiation therapy for treatment of endometrial carcinoma; prior radiation therapy may have included pelvic radiation therapy, extended field pelvic/para-aortic radiation therapy, and/or intravaginal brachytherapy; all radiation therapy must be completed at least 4 weeks prior to the first date of study therapy
  • Patients may have received prior hormonal therapy for treatment of endometrial carcinoma; all hormonal therapy must be discontinued at least one week prior to the first date of study therapy
  • Patients must be able to swallow and retain orally-administered medication
  • Patients must have signed an approved informed consent and authorization permitting release of personal health information; individuals with impaired decision-making capacity are not eligible to participate on the study

Exclusion Criteria

  • Patients must NOT be taking metformin or have been on metformin in the past 6 months
  • Patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer are excluded if there is any evidence of other malignancy being present within the last three years
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Patients who are pregnant or nursing; if patients are of reproductive age and have not undergone hysterectomy, they must use an effective contraceptive method for the duration of this study
  • Any condition associated with increased risk of metformin-associated lactic acidosis; (e.g. congestive heart failure defined as New York Heart Association [NYHA] class III or IV functional status, history of acidosis of any type; habitual intake of 3 or more alcoholic beverages per day)

Alabama

Birmingham
University of Alabama at Birmingham Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Warner King Huh
Phone: 412-339-5294
Huntsville
Tennessee Valley Gynecologic Oncology
Status: CLOSED_TO_ACCRUAL
Contact: David Bryan Engle
Phone: 256-533-6233

Arizona

Phoenix
Arizona Oncology Associates-Biltmore Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 602-277-4868
Cancer Center at Saint Joseph's
Status: CLOSED_TO_ACCRUAL
Contact: John Hall Farley
Phone: 412-339-5294
Saint Joseph's Hospital and Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John Hall Farley
Phone: 623-207-3000
Tucson
Arizona Oncology Associates-West Orange Grove
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-544-2919
Arizona Oncology Associates-Wilmot
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-269-3821
Banner University Medical Center - Tucson
Status: CLOSED_TO_ACCRUAL
Contact: Setsuko Kuki Chambers
Phone: 520-626-9008
University of Arizona Cancer Center-North Campus
Status: CLOSED_TO_ACCRUAL
Contact: Setsuko Kuki Chambers
Phone: 800-327-2873

Arkansas

Little Rock
University of Arkansas for Medical Sciences
Status: CLOSED_TO_ACCRUAL
Contact: Kristin Kelley Zorn
Phone: 501-686-8274

California

Concord
John Muir Medical Center-Concord Campus
Status: CLOSED_TO_ACCRUAL
Contact: Babak Edraki
Phone: 925-674-2580
La Jolla
UC San Diego Moores Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael T. McHale
Phone: 858-822-5354
Los Angeles
Cedars Sinai Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Bobbie Jo Rimel
Phone: 310-423-8965
Kaiser Permanente Los Angeles Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Scott E. Lentz
Phone: 626-564-3455
Los Angeles County-USC Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Huyen Q. Pham
Phone: 323-865-0451
UCLA / Jonsson Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Robin Farias-Eisner
Phone: 888-798-0719
USC / Norris Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Huyen Q. Pham
Phone: 323-865-0451
Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology
Status: CLOSED_TO_ACCRUAL
Contact: John K. Chan
Phone: 415-209-2686
Oakland
Kaiser Permanente-Oakland
Status: CLOSED_TO_ACCRUAL
Contact: Ramey Drew Littell
Phone: 510-891-3400
Orange
Saint Joseph Hospital - Orange
Status: CLOSED_TO_ACCRUAL
Contact: Chuan-Ju Gwendolyn Pan
Phone: 714-734-6220
UC Irvine Health / Chao Family Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Krishnansu Sujata Tewari
Phone: 877-827-8839
Palo Alto
Palo Alto Medical Foundation Health Care
Status: CLOSED_TO_ACCRUAL
Contact: John K. Chan
Phone: 415-209-2686
Stanford Cancer Institute Palo Alto
Status: CLOSED_TO_ACCRUAL
Contact: Oliver Dorigo
Phone: 650-498-7061
Pasadena
Keck Medical Center of USC Pasadena
Status: CLOSED_TO_ACCRUAL
Contact: Huyen Q. Pham
Phone: 323-865-0451
Roseville
Kaiser Permanente-Roseville
Status: CLOSED_TO_ACCRUAL
Contact: Ramey Drew Littell
Phone: 510-891-3400
Sacramento
Kaiser Permanente - Sacramento
Status: CLOSED_TO_ACCRUAL
Contact: Ramey Drew Littell
Phone: 510-891-3400
University of California Davis Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Vanessa A. Kennedy
Phone: 916-734-3089
San Francisco
California Pacific Medical Center-Pacific Campus
Status: CLOSED_TO_ACCRUAL
Contact: John K. Chan
Phone: 415-209-2686
Kaiser Permanente-San Francisco
Status: CLOSED_TO_ACCRUAL
Contact: Ramey Drew Littell
Phone: 510-891-3400
UCSF Medical Center-Mission Bay
Status: CLOSED_TO_ACCRUAL
Contact: Lee-May Chen
Phone: 877-827-3222
UCSF Medical Center-Mount Zion
Status: CLOSED_TO_ACCRUAL
Contact: Lee-May Chen
Phone: 877-827-3222
Zuckerberg San Francisco General Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Lee-May Chen
Phone: 415-476-4082
San Jose
Kaiser Permanente-Santa Teresa-San Jose
Status: CLOSED_TO_ACCRUAL
Contact: Ramey Drew Littell
Phone: 510-891-3400
San Leandro
Kaiser Permanente San Leandro
Status: CLOSED_TO_ACCRUAL
Contact: Ramey Drew Littell
Phone: 510-454-2724
Santa Clara
Kaiser Permanente Medical Center - Santa Clara
Status: CLOSED_TO_ACCRUAL
Contact: Ramey Drew Littell
Phone: 510-891-3400
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Status: CLOSED_TO_ACCRUAL
Contact: John K. Chan
Phone: 415-209-2686
South San Francisco
Kaiser Permanente-South San Francisco
Status: CLOSED_TO_ACCRUAL
Contact: Ramey Drew Littell
Phone: 510-891-3400
Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
Status: CLOSED_TO_ACCRUAL
Contact: John K. Chan
Phone: 415-209-2686
Sylmar
Olive View-University of California Los Angeles Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Christine H. Holschneider
Phone: 818-364-1555
Vallejo
Kaiser Permanente-Vallejo
Status: CLOSED_TO_ACCRUAL
Contact: Ramey Drew Littell
Phone: 510-891-3400
Walnut Creek
John Muir Medical Center-Walnut Creek
Status: CLOSED_TO_ACCRUAL
Contact: Babak Edraki
Phone: 925-941-4246
Kaiser Permanente-Walnut Creek
Status: CLOSED_TO_ACCRUAL
Contact: Ramey Drew Littell
Phone: 510-891-3400

Colorado

Aurora
University of Colorado Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Saketh Ram Guntupalli
Phone: 720-848-0650
Colorado Springs
Penrose-Saint Francis Healthcare
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 308-398-6518
Fort Collins
Poudre Valley Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Saketh Ram Guntupalli
Phone: 970-297-6150

Connecticut

Derby
Smilow Cancer Hospital-Derby Care Center
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Ratner
Phone: 855-476-4569
Fairfield
Smilow Cancer Hospital Care Center-Fairfield
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Ratner
Phone: 855-476-4569
Guilford
Smilow Cancer Hospital Care Center - Guiford
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Ratner
Phone: 877-978-8343
Hartford
Hartford Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Amy Kirkpatrick Brown
Phone: 860-545-5363
Smilow Cancer Hospital Care Center at Saint Francis
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Ratner
Phone: 860-714-4680
Meriden
Midstate Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Amy Kirkpatrick Brown
Phone: 866-662-5678
New Britain
The Hospital of Central Connecticut
Status: CLOSED_TO_ACCRUAL
Contact: Amy Kirkpatrick Brown
Phone: 860-224-5660
New Haven
Yale University
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Ratner
Phone: 203-785-5702
North Haven
Yale-New Haven Hospital North Haven Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Ratner
Phone: 877-978-8343
Orange
Smilow Cancer Hospital-Orange Care Center
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Ratner
Phone: 855-476-4569
Torrington
Smilow Cancer Hospital-Torrington Care Center
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Ratner
Phone: 860-482-5384
Trumbull
Smilow Cancer Hospital Care Center-Trumbull
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Ratner
Phone: 855-476-4569
Waterbury
Smilow Cancer Hospital-Waterbury Care Center
Status: CLOSED_TO_ACCRUAL
Contact: Elena S. Ratner
Phone: 855-476-4569

Delaware

Newark
Christiana Care Health System-Christiana Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Gregory Andrew Masters
Phone: 302-623-4450
Christiana Gynecologic Oncology LLC
Status: TEMPORARILY_CLOSED_TO_ACCRUAL
Contact: Gregory Andrew Masters
Phone: 302-733-6227
Helen F Graham Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Gregory Andrew Masters
Phone: 302-623-4450
Medical Oncology Hematology Consultants PA
Status: CLOSED_TO_ACCRUAL
Contact: Gregory Andrew Masters
Phone: 302-623-4450
Rehoboth Beach
Beebe Health Campus
Status: CLOSED_TO_ACCRUAL
Contact: Gregory Andrew Masters
Phone: 302-645-3100
Wilmington
Christiana Care Health System-Wilmington Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Gregory Andrew Masters
Phone: 302-623-4450

Florida

Gainesville
University of Florida Health Science Center - Gainesville
Status: CLOSED_TO_ACCRUAL
Contact: Merry Jennifer Markham
Phone: 412-339-5294
Orlando
AdventHealth Orlando
Status: CLOSED_TO_ACCRUAL
Contact: James Erasmus Kendrick
Phone: 407-303-2090
Saint Petersburg
Women's Cancer Associates
Status: CLOSED_TO_ACCRUAL
Contact: Megan Dawn Indermaur
Phone: 412-339-5294
Sarasota
Sarasota Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James Vincent Fiorica
Phone: 941-917-2225

Georgia

Atlanta
Emory University Hospital / Winship Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Namita Khanna
Phone: 404-778-1868
Emory University Hospital Midtown
Status: CLOSED_TO_ACCRUAL
Contact: Namita Khanna
Phone: 888-946-7447
Northside Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Guilherme Henrique C. Cantuaria
Phone: 404-303-3355
Augusta
Augusta University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Sharad Anant Ghamande
Phone: 706-721-1663
Decatur
Dekalb Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Sharad Anant Ghamande
Phone: 404-501-3279
Gainesville
Northeast Georgia Medical Center-Gainesville
Status: CLOSED_TO_ACCRUAL
Contact: Andrew Emmons Green
Phone: 770-219-8800
Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's / Candler
Status: CLOSED_TO_ACCRUAL
Contact: William Edward Richards
Phone: 412-339-5294

Hawaii

Aiea
Pali Momi Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-486-6000
Queen's Cancer Center - Pearlridge
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 412-339-5294
The Cancer Center of Hawaii-Pali Momi
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-678-9000
Honolulu
Hawaii Cancer Care Inc-Liliha
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-536-4888
Hawaii Cancer Care Inc-POB II
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-524-6115
Kapiolani Medical Center for Women and Children
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-983-6090
Kuakini Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-547-9816
Queen's Cancer Center - Kuakini
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-531-8521
Queen's Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 412-339-5294
Straub Clinic and Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-522-4333
The Cancer Center of Hawaii-Liliha
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-547-6011
University of Hawaii Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-586-2979
Lihue
Wilcox Memorial Hospital and Kauai Medical Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Michael Ethan Carney
Phone: 808-535-7960

Idaho

Boise
Saint Alphonsus Cancer Care Center-Boise
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 734-712-3671

Illinois

Arlington Heights
Northwest Community Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Stephen Schaeffer Nigh
Phone: 847-618-4968
Aurora
Rush - Copley Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 630-978-6212
Bloomington
Illinois CancerCare-Bloomington
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Canton
Illinois CancerCare-Canton
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Carthage
Illinois CancerCare-Carthage
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Chicago
Northwestern University
Status: CLOSED_TO_ACCRUAL
Contact: Shohreh Shahabi
Phone: 312-695-1301
Rush University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Summer B. Dewdney
Phone: 312-942-5498
University of Chicago Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: John William Moroney
Phone: 773-834-7424
Danville
Carle on Vermilion
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Decatur
Cancer Care Specialists of Illinois - Decatur
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4740
Decatur Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-6601
Effingham
Carle Physician Group-Effingham
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Crossroads Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-342-2066
Elk Grove Village
AMITA Health Alexian Brothers Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Kevin Patrick McKian
Phone: 847-952-7164
Eureka
Illinois CancerCare-Eureka
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Evanston
NorthShore University HealthSystem-Evanston Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jean A. Hurteau
Phone: 847-570-2109
Galesburg
Illinois CancerCare-Galesburg
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Geneva
Northwestern Medicine Cancer Center Delnor
Status: CLOSED_TO_ACCRUAL
Contact: LaToya J. Perry
Phone: 630-315-1918
Glenview
NorthShore University HealthSystem-Glenbrook Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jean A. Hurteau
Phone: 847-570-2109
Highland Park
NorthShore University HealthSystem-Highland Park Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jean A. Hurteau
Phone: 847-570-2109
Hinsdale
Sudarshan K Sharma MD Limited-Gynecologic Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Sudarshan K. Sharma
Phone: 630-856-6757
Kewanee
Illinois CancerCare-Kewanee Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Macomb
Illinois CancerCare-Macomb
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Mattoon
Carle Physician Group-Mattoon / Charleston
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
New Lenox
UC Comprehensive Cancer Center at Silver Cross
Status: CLOSED_TO_ACCRUAL
Contact: John William Moroney
Phone: 815-300-1400
O'Fallon
Cancer Care Center of O'Fallon
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-876-4755
Orland Park
University of Chicago Medicine-Orland Park
Status: CLOSED_TO_ACCRUAL
Contact: John William Moroney
Phone: 773-834-7424
Ottawa
Illinois CancerCare-Ottawa Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Pekin
Illinois CancerCare-Pekin
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Peoria
Illinois CancerCare-Peoria
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Peru
Illinois CancerCare-Peru
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Princeton
Illinois CancerCare-Princeton
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Skokie
North Shore Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Jean A. Hurteau
Phone: 412-339-5294
Springfield
Central Illinois Hematology Oncology Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 309-243-3605
Memorial Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-788-4233
Southern Illinois University School of Medicine
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 217-545-7929
Springfield Clinic
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 800-444-7541
Urbana
Carle Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
The Carle Foundation Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Warrenville
Northwestern Medicine Cancer Center Warrenville
Status: CLOSED_TO_ACCRUAL
Contact: LaToya J. Perry
Phone: 630-315-1918
Yorkville
Rush-Copley Healthcare Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 630-978-6212

Indiana

Crown Point
Michiana Hematology Oncology PC-Crown Point
Status: CLOSED_TO_ACCRUAL
Contact: Eduardo Braun
Phone: 219-836-3349
Elkhart
Elkhart General Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Michael W. Method
Phone: 317-497-2823
Michiana Hematology Oncology PC-Elkhart
Status: CLOSED_TO_ACCRUAL
Contact: Eduardo Braun
Phone: 219-836-3349
Indianapolis
Indiana University / Melvin and Bren Simon Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Jeanne Marie Schilder
Phone: 412-339-5294
Saint Vincent Hospital and Health Care Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael J. Callahan
Phone: 317-338-2194
La Porte
IU Health La Porte Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Michael W. Method
Phone: 317-497-2823
Michigan City
Franciscan Saint Anthony Health-Michigan City
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 800-931-3322
Woodland Cancer Care Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria T. Grosse-Perdekamp
Phone: 888-823-5923
Mishawaka
Michiana Hematology Oncology PC-Mishawaka
Status: CLOSED_TO_ACCRUAL
Contact: Eduardo Braun
Phone: 219-836-3349
Saint Joseph Regional Medical Center-Mishawaka
Status: CLOSED_TO_ACCRUAL
Contact: Michael W. Method
Phone: 317-497-2823
South Bend
Michiana Hematology Oncology PC-South Bend
Status: TEMPORARILY_CLOSED_TO_ACCRUAL
Contact: Eduardo Braun
Phone: 219-785-3400
Westville
Michiana Hematology Oncology PC-Westville
Status: CLOSED_TO_ACCRUAL
Contact: Eduardo Braun
Phone: 219-836-3349

Iowa

Ames
Mary Greeley Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
McFarland Clinic PC - Ames
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
Boone
McFarland Clinic PC-Boone
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
Clive
Medical Oncology and Hematology Associates-West Des Moines
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 308-398-6518
Mercy Cancer Center-West Lakes
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 308-398-6518
Des Moines
Medical Oncology and Hematology Associates-Laurel
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 308-398-6518
Mercy Medical Center - Des Moines
Status: TEMPORARILY_CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 800-998-2119
Fort Dodge
McFarland Clinic PC-Trinity Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
Iowa City
University of Iowa / Holden Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: David Paul Bender
Phone: 800-237-1225
Jefferson
McFarland Clinic PC-Jefferson
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
Marshalltown
McFarland Clinic PC-Marshalltown
Status: CLOSED_TO_ACCRUAL
Contact: Joseph James Merchant
Phone: 515-239-2621
Mason City
Mercy Medical Center - North Iowa
Status: CLOSED_TO_ACCRUAL
Contact: Arvind Y. Vemula
Phone: 800-433-3883

Kentucky

Edgewood
Saint Elizabeth Medical Center South
Status: CLOSED_TO_ACCRUAL
Contact: Kevin M. Schuler
Phone: 859-301-5473
Fort Thomas
Saint Elizabeth Fort Thomas
Status: CLOSED_TO_ACCRUAL
Contact: Kevin M. Schuler
Phone: 859-301-5473
Lexington
University of Kentucky / Markey Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Frederick Rand Ueland
Phone: 859-257-3379

Louisiana

Baton Rouge
Woman's Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Milton Giles Fort
Phone: 412-339-5294
New Orleans
Ochsner Medical Center Jefferson
Status: CLOSED_TO_ACCRUAL
Contact: Richard Carl Kline
Phone: 504-703-8712

Maine

Scarborough
Maine Medical Center- Scarborough Campus
Status: CLOSED_TO_ACCRUAL
Contact: Christopher J. Darus
Phone: 207-396-8090

Maryland

Baltimore
Greater Baltimore Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Paul Celano
Phone: 443-849-3706
Johns Hopkins University / Sidney Kimmel Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Deborah Kay Armstrong
Phone: 410-955-8804
Sinai Hospital of Baltimore
Status: CLOSED_TO_ACCRUAL
Contact: Abbie L. Fields
Phone: 410-601-6120
Bethesda
Walter Reed National Military Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: William J. Lowery
Phone: 301-319-2100

Massachusetts

Boston
Beth Israel Deaconess Medical Center
Status: COMPLETED
Contact: Neil Stuart Horowitz
Phone: 617-667-9925
Brigham and Women's Hospital
Status: COMPLETED
Contact: Neil Stuart Horowitz
Phone: 412-339-5294
Dana-Farber Cancer Institute
Status: COMPLETED
Contact: Neil Stuart Horowitz
Phone: 877-442-3324
Tufts Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Young Bae Kim
Phone: 617-636-5000
Lowell
Lowell General Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Blair Ardman
Phone: 978-788-7084
Springfield
Baystate Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Tashanna Keisha Nicole Myers
Phone: 413-794-3565
Worcester
UMass Memorial Medical Center - Memorial Division
Status: CLOSED_TO_ACCRUAL
Contact: Susan Lee Zweizig
Phone: 508-856-6265

Michigan

Ann Arbor
Michigan Cancer Research Consortium NCORP
Status: ADMINISTRATIVELY_COMPLETE
Contact: Philip J. Stella
Phone: 734-712-4673
Saint Joseph Mercy Hospital
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 734-712-3671
University of Michigan Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Carolyn M. Johnston
Phone: 800-865-1125
Battle Creek
Bronson Battle Creek
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Dearborn
Beaumont Hospital - Dearborn
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 248-551-7695
Detroit
Wayne State University / Karmanos Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Robert Thomas Morris
Phone: 313-576-9363
Escanaba
Green Bay Oncology - Escanaba
Status: CLOSED_TO_ACCRUAL
Contact: Jonathan Edward Tammela
Phone: 920-433-8889
Farmington Hills
Weisberg Cancer Treatment Center
Status: CLOSED_TO_ACCRUAL
Contact: Robert Thomas Morris
Phone: 313-576-9363
Flint
Genesys Hurley Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 734-712-3671
Hurley Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 734-712-3671
Grand Rapids
Helen DeVos Children's Hospital at Spectrum Health
Status: CLOSED_TO_ACCRUAL
Contact: Gilbert D.A. Padula
Phone: 412-339-5294
Mercy Health Saint Mary's
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 412-339-5294
Spectrum Health at Butterworth Campus
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Iron Mountain
Green Bay Oncology - Iron Mountain
Status: ACTIVE
Contact: Jonathan Edward Tammela
Phone: 920-433-8889
Jackson
Allegiance Health
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 517-788-4800
Kalamazoo
West Michigan Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Lansing
Sparrow Hospital
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 734-712-3671
Livonia
Saint Mary Mercy Hospital
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 734-712-3671
Monroe
Monroe Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Adam C. Walter
Phone: 412-339-5294
Muskegon
Mercy Health Mercy Campus
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Pontiac
Saint Joseph Mercy Oakland
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 734-712-3671
Port Huron
Lake Huron Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Philip J. Stella
Phone: 702-384-0013
Reed City
Spectrum Health Reed City Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Royal Oak
William Beaumont Hospital-Royal Oak
Status: CLOSED_TO_ACCRUAL
Contact: Jayson Bert Field
Phone: 248-551-7695
Saginaw
Ascension Saint Mary's Hospital
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 412-339-5294
Traverse City
Munson Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Kathleen J. Yost
Phone: 616-391-1230
Troy
William Beaumont Hospital - Troy
Status: CLOSED_TO_ACCRUAL
Contact: Jayson Bert Field
Phone: 248-551-7695
Warren
Saint John Macomb-Oakland Hospital
Status: CLOSED_TO_ACCRUAL
Contact: J. Rebecca Liu
Phone: 734-712-3671

Minnesota

Bemidji
Sanford Joe Lueken Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria Caroline Bell
Phone: 218-333-5000
Coon Rapids
Mercy Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Rachel E. Lerner
Phone: 952-993-1517
Edina
Fairview Southdale Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Rachel E. Lerner
Phone: 952-993-1517
Minneapolis
Abbott-Northwestern Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Rachel E. Lerner
Phone: 952-993-1517
University of Minnesota / Masonic Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Melissa A. Geller
Phone: 412-339-5294
Rochester
Mayo Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Gretchen E. Glaser
Phone: 855-776-0015
Saint Louis Park
Metro Minnesota Community Oncology Research Consortium
Status: ADMINISTRATIVELY_COMPLETE
Contact: Matthew P. Boente
Phone: 952-993-1517
Park Nicollet Clinic - Saint Louis Park
Status: CLOSED_TO_ACCRUAL
Contact: Rachel E. Lerner
Phone: 952-993-1517
Saint Paul
United Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Rachel E. Lerner
Phone: 952-993-1517
Stillwater
Lakeview Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Rachel E. Lerner
Phone: 952-993-1517
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Status: CLOSED_TO_ACCRUAL
Contact: Rachel E. Lerner
Phone: 952-993-1517

Mississippi

Jackson
Saint Dominic-Jackson Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Donald Paul Seago
Phone: 601-200-3300
University of Mississippi Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Kelly Jeanes Wilkinson
Phone: 601-815-6700

Missouri

Cape Girardeau
Saint Francis Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Lloyd Wade
Phone: 573-334-2230
Email: sfmc@sfmc.net
Rolla
Delbert Day Cancer Institute at PCRMC
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 573-458-7504
Mercy Clinic-Rolla-Cancer and Hematology
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 573-458-7504
Saint Louis
Barnes-Jewish Hospital
Status: CLOSED_TO_ACCRUAL
Contact: David Gardner Mutch
Phone: 800-600-3606
Mercy Hospital Saint Louis
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 314-251-6770
Washington University School of Medicine
Status: CLOSED_TO_ACCRUAL
Contact: David Gardner Mutch
Phone: 800-600-3606
Springfield
Cancer Research for the Ozarks NCORP
Status: ADMINISTRATIVELY_COMPLETE
Contact: Jay W. Carlson
Phone: 800-821-7532
CoxHealth South Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 417-269-4520
Mercy Hospital Springfield
Status: CLOSED_TO_ACCRUAL
Contact: Jay W. Carlson
Phone: 417-269-4520

Montana

Billings
Billings Clinic Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 800-996-2663
Great Falls
Benefis Healthcare- Sletten Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 406-969-6060
Kalispell
Kalispell Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Benjamin T. Marchello
Phone: 406-969-6060

Nebraska

Grand Island
CHI Health Saint Francis
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 308-398-6518
Kearney
CHI Health Good Samaritan
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 308-398-6518
Omaha
Nebraska Methodist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Brent Jonathan Tierney
Phone: 402-354-5144
University of Nebraska Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Kerry Julene Rodabaugh
Phone: 402-559-6941

Nevada

Las Vegas
Women's Cancer Center of Nevada
Status: CLOSED_TO_ACCRUAL
Contact: Nicola M. Spirtos
Phone: 412-339-5294
Reno
Center of Hope at Renown Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Peter Christopher-Why Lim
Phone: 866-513-8227
Renown Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Peter Christopher-Why Lim
Phone: 702-384-0013

New Hampshire

Dover
Wentworth-Douglass Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Henry Leo Sonneborn
Phone: 603-740-2150
Lebanon
Dartmouth Hitchcock Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Leslie R. DeMars
Phone: 800-639-6918

New Jersey

Basking Ridge
Memorial Sloan Kettering Basking Ridge
Status: CLOSED_TO_ACCRUAL
Contact: Carol Aghajanian
Phone: 212-639-7202
Camden
Cooper Hospital University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: David Philip Warshal
Phone: 856-325-6757
Middletown
Memorial Sloan Kettering Monmouth
Status: CLOSED_TO_ACCRUAL
Contact: Carol Aghajanian
Phone: 212-639-7202
Morristown
Morristown Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Paul Heller
Phone: 973-971-5900
Mount Holly
Virtua Memorial
Status: CLOSED_TO_ACCRUAL
Contact: Randolph Bruce Deger
Phone: 609-914-6762
Summit
Overlook Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Paul Heller
Phone: 908-522-2043
Voorhees
MD Anderson Cancer Center at Cooper-Voorhees
Status: CLOSED_TO_ACCRUAL
Contact: David Philip Warshal
Phone: 856-325-6757
Virtua Voorhees
Status: CLOSED_TO_ACCRUAL
Contact: Randolph Bruce Deger
Phone: 856-247-7395

New Mexico

Albuquerque
Southwest Gynecologic Oncology Associates Inc
Status: CLOSED_TO_ACCRUAL
Contact: Teresa L. Rutledge
Phone: 505-272-0530
University of New Mexico Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Teresa L. Rutledge
Phone: 505-925-0366

New York

Albany
Women's Cancer Care Associates LLC
Status: CLOSED_TO_ACCRUAL
Contact: Joyce Nuqui Barlin
Phone: 412-339-5294
Bronx
Montefiore Medical Center - Moses Campus
Status: CLOSED_TO_ACCRUAL
Contact: Nicole S. Nevadunsky
Phone: 718-904-2730
Montefiore Medical Center-Einstein Campus
Status: CLOSED_TO_ACCRUAL
Contact: Nicole S. Nevadunsky
Phone: 718-904-2730
Montefiore Medical Center-Weiler Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Nicole S. Nevadunsky
Phone: 718-904-2730
Brooklyn
New York-Presbyterian / Brooklyn Methodist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Katherine Economos
Phone: 718-780-3677
State University of New York Downstate Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Ovadia Abulafia
Phone: 718-613-8324
Buffalo
Roswell Park Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Shashikant B. Lele
Phone: 877-275-7724
Commack
Memorial Sloan Kettering Commack
Status: CLOSED_TO_ACCRUAL
Contact: Carol Aghajanian
Phone: 212-639-7202
Glens Falls
Glens Falls Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Cheung Wong
Phone: 518-926-6700
Mineola
NYU Winthrop Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Eva Chalas
Phone: 516-663-3115
New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Status: CLOSED_TO_ACCRUAL
Contact: Bhavana Pothuri
Phone: 212-263-4434
Memorial Sloan Kettering Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Carol Aghajanian
Phone: 212-639-7202
Mount Sinai Hospital
Status: COMPLETED
Contact: Monica Prasad Hayes
Phone: 212-824-7309
Email: CCTO@mssm.edu
Mount Sinai Union Square
Status: CLOSED_TO_ACCRUAL
Contact: Monica Prasad Hayes
Phone: 212-844-6286
NYP / Columbia University Medical Center / Herbert Irving Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Jason D. Wright
Phone: 212-305-8615
Sleepy Hollow
Memorial Sloan Kettering Sleepy Hollow
Status: CLOSED_TO_ACCRUAL
Contact: Carol Aghajanian
Phone: 212-639-7202
Stony Brook
Stony Brook University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael L. Pearl
Phone: 800-862-2215
Uniondale
Memorial Sloan Kettering Nassau
Status: CLOSED_TO_ACCRUAL
Contact: Carol Aghajanian
Phone: 212-639-7202
Valhalla
Westchester Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Sean Shaheen Tedjarati
Phone: 412-339-5294
West Harrison
Memorial Sloan Kettering Westchester
Status: CLOSED_TO_ACCRUAL
Contact: Carol Aghajanian
Phone: 412-339-5294
White Plains
Dickstein Cancer Treatment Center
Status: CLOSED_TO_ACCRUAL
Contact: Dan Costin
Phone: 914-849-7582

North Carolina

Chapel Hill
UNC Lineberger Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Linda Van Le
Phone: 877-668-0683
Charlotte
Carolinas Medical Center / Levine Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Robert Victor Higgins
Phone: 704-355-2884
Novant Health Presbyterian Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: John Matthew McDonald
Phone: 704-384-5369
Clinton
Southeastern Medical Oncology Center-Clinton
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 412-339-5294
Concord
Atrium Health Cabarrus / LCI-Concord
Status: CLOSED_TO_ACCRUAL
Contact: Robert Victor Higgins
Phone: 704-403-1520
Durham
Duke University Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Angeles Alvarez Secord
Phone: 888-275-3853
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 919-580-0000
Wayne Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 919-731-6687
Hendersonville
AdventHealth Hendersonville
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 855-774-5433
Jacksonville
Onslow Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 412-339-5294
Southeastern Medical Oncology Center-Jacksonville
Status: CLOSED_TO_ACCRUAL
Contact: James N. Atkins
Phone: 888-774-0309
Kernersville
Novant Health Oncology Specialists-Kernersville
Status: CLOSED_TO_ACCRUAL
Contact: Judith Owen Hopkins
Phone: 412-339-5294
Mount Airy
Novant Health Oncology Specialists-Mount Airy
Status: CLOSED_TO_ACCRUAL
Contact: Judith Owen Hopkins
Phone: 412-339-5294
Pinehurst
FirstHealth of the Carolinas-Moore Regional Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Michael John Sundborg
Phone: 910-715-2200
Raleigh
Duke Raleigh Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Angeles Alvarez Secord
Phone: 919-862-5400
Stateville
Novant Health Oncology Specialists-Statesville
Status: CLOSED_TO_ACCRUAL
Contact: Judith Owen Hopkins
Phone: 412-339-5294
Thomasville
Novant Health Oncology Specialists-Davidson County
Status: CLOSED_TO_ACCRUAL
Contact: Judith Owen Hopkins
Phone: 336-718-8335
Wilkesboro
Novant Health Oncology Specialists-Wilkesboro
Status: CLOSED_TO_ACCRUAL
Contact: Judith Owen Hopkins
Phone: 412-339-5294
Wilmington
New Hanover Regional Medical Center / Zimmer Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Walter H. Gajewski
Phone: 910-342-3000
Winston-Salem
Novant Health Oncology Specialists
Status: CLOSED_TO_ACCRUAL
Contact: Judith Owen Hopkins
Phone: 336-277-8800
Wake Forest University Health Sciences
Status: CLOSED_TO_ACCRUAL
Contact: Samuel Smith Lentz
Phone: 336-713-6771
Winston-Salem Health Care
Status: CLOSED_TO_ACCRUAL
Contact: Judith Owen Hopkins
Phone: 336-277-8887

North Dakota

Bismarck
Sanford Bismarck Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria Caroline Bell
Phone: 701-323-5760
Fargo
Sanford Broadway Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria Caroline Bell
Phone: 800-437-4010
Sanford Clinic North-Fargo
Status: ACTIVE
Contact: Maria Caroline Bell
Phone: 218-333-5000
Sanford Roger Maris Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria Caroline Bell
Phone: 701-234-6161

Ohio

Akron
Summa Health System - Akron Campus
Status: CLOSED_TO_ACCRUAL
Contact: Stephen J. Andrews
Phone: 330-615-4132
Cincinnati
Bethesda North Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 308-398-6518
Good Samaritan Hospital - Cincinnati
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 308-398-6518
University of Cincinnati / Barrett Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Eric Lawrence Eisenhauer
Phone: 513-558-4553
Cleveland
Case Western Reserve University
Status: CLOSED_TO_ACCRUAL
Contact: Steven E. Waggoner
Phone: 800-641-2422
Cleveland Clinic Cancer Center / Fairview Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Peter G. Rose
Phone: 216-476-9362
Cleveland Clinic Foundation
Status: CLOSED_TO_ACCRUAL
Contact: Peter G. Rose
Phone: 866-223-8100
Columbus
Columbus NCI Community Oncology Research Program
Status: ADMINISTRATIVELY_COMPLETE
Contact: John Philip Kuebler
Phone: 614-566-3275
Ohio State University Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: David M. O'Malley
Phone: 800-293-5066
Riverside Methodist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 614-566-4475
The Mark H Zangmeister Center
Status: CLOSED_TO_ACCRUAL
Contact: Timothy David Moore
Phone: 412-339-5294
Dayton
Good Samaritan Hospital - Dayton
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Grandview Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Thomas J. A. Reid
Phone: 937-395-8115
Miami Valley Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Miami Valley Hospital North
Status: CLOSED_TO_ACCRUAL
Contact: Howard M. Gross
Phone: 937-775-1350
Mayfield Heights
Hillcrest Hospital Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Peter G. Rose
Phone: 440-312-4293
Mentor
UH Seidman Cancer Center at Lake Health Mentor Campus
Status: CLOSED_TO_ACCRUAL
Contact: Steven E. Waggoner
Phone: 440-205-5491
Sylvania
ProMedica Flower Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Adam C. Walter
Phone: 419-824-1842
Toledo
ProMedica Toledo Hospital / Russell J Ebeid Children's Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Adam C. Walter
Phone: 419-824-1842
WPAFB
Wright-Patterson Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Yovanni Casablanca
Phone: 937-775-1350

Oklahoma

Oklahoma City
University of Oklahoma Health Sciences Center
Status: CLOSED_TO_ACCRUAL
Contact: Robert S. Mannel
Phone: 405-271-8777
Tulsa
Oklahoma Cancer Specialists and Research Institute-Tulsa
Status: CLOSED_TO_ACCRUAL
Contact: Robert S. Mannel
Phone: 918-505-3200

Pennsylvania

Abington
Abington Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mark Shahram Shahin
Phone: 215-481-2402
Bethlehem
Saint Luke's University Hospital-Bethlehem Campus
Status: CLOSED_TO_ACCRUAL
Contact: Nicholas P. Taylor
Phone: 412-339-5294
Danville
Geisinger Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Radhika P. Gogoi
Phone: 570-271-5251
Gettysburg
Adams Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Mark A. Miller
Phone: 877-441-7957
Greensburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Status: CLOSED_TO_ACCRUAL
Contact: Alexander Babatunde Olawaiye
Phone: 724-838-1900
Hanover
Cherry Tree Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Mark A. Miller
Phone: 877-441-7957
Hazleton
Geisinger Medical Center-Cancer Center Hazleton
Status: CLOSED_TO_ACCRUAL
Contact: Radhika P. Gogoi
Phone: 570-459-2901
Lewisburg
Geisinger Medical Oncology-Lewisburg
Status: CLOSED_TO_ACCRUAL
Contact: Radhika P. Gogoi
Phone: 570-374-8555
Lewistown
Lewistown Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Radhika P. Gogoi
Phone: 717-242-7703
Philadelphia
Fox Chase Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Angela Jain
Phone: 215-728-4790
Temple University Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Enrique Hernandez
Phone: 215-728-2983
Thomas Jefferson University Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Christine Heesun Kim
Phone: 215-955-6084
University of Pennsylvania / Abramson Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Robert Allen Burger
Phone: 800-474-9892
Pittsburgh
UPMC-Magee Womens Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Alexander Babatunde Olawaiye
Phone: 412-647-2811
UPMC-Passavant Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Alexander Babatunde Olawaiye
Phone: 412-367-6454
University of Pittsburgh Cancer Institute (UPCI)
Status: CLOSED_TO_ACCRUAL
Contact: Alexander Babatunde Olawaiye
Phone: 412-647-8073
Pottsville
Geisinger Cancer Services-Pottsville
Status: CLOSED_TO_ACCRUAL
Contact: Radhika P. Gogoi
Phone: 800-275-6401
Seneca
UPMC Cancer Center at UPMC Northwest
Status: CLOSED_TO_ACCRUAL
Contact: Alexander Babatunde Olawaiye
Phone: 814-676-7900
State College
Geisinger Medical Group
Status: CLOSED_TO_ACCRUAL
Contact: Radhika P. Gogoi
Phone: 570-271-5251
Uniontown
UPMC Uniontown Hospital Radiation Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Alexander Babatunde Olawaiye
Phone: 724-437-2503
West Chester
Chester County Hospital
Status: CLOSED_TO_ACCRUAL
Contact: William Emil Luginbuhl
Phone: 610-431-5297
West Reading
Reading Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Bernice L. Robinson-Bennett
Phone: 610-988-9323
Wilkes-Barre
Geisinger Wyoming Valley / Henry Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Radhika P. Gogoi
Phone: 570-271-5251
York
WellSpan Health-York Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Mark A. Miller
Phone: 877-441-7957

Rhode Island

Providence
Women and Infants Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Paul A. DiSilvestro
Phone: 401-274-1122

South Carolina

Anderson
AnMed Health Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 864-512-1000
Charleston
Medical University of South Carolina
Status: CLOSED_TO_ACCRUAL
Contact: Whitney Spannuth Graybill
Phone: 843-792-9321
Greenville
Saint Francis Hospital
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 864-255-1713
Greer
Gibbs Cancer Center-Pelham
Status: CLOSED_TO_ACCRUAL
Contact: James Elmo Hunter
Phone: 412-339-5294
Lancaster
Carolina Blood and Cancer Care Associates PA-Lancaster
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 888-823-5923
Rock Hill
Carolina Blood and Cancer Care Associates PA
Status: CLOSED_TO_ACCRUAL
Contact: David Griffin
Phone: 888-823-5923
Spartanburg
Spartanburg Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: James Elmo Hunter
Phone: 800-486-5941

South Dakota

Rapid City
Black Hills Obstetrics and Gynecology
Status: CLOSED_TO_ACCRUAL
Contact: Helen L. Frederickson
Phone: 605-343-9224
Rapid City Regional Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Michael O. Robinson
Phone: 605-716-3982
Sioux Falls
Avera Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Luis A. Rojas-Espaillat
Phone: 888-634-7268
Sanford Cancer Center Oncology Clinic
Status: CLOSED_TO_ACCRUAL
Contact: Maria Caroline Bell
Phone: 605-312-3320
Sanford USD Medical Center - Sioux Falls
Status: CLOSED_TO_ACCRUAL
Contact: Maria Caroline Bell
Phone: 605-312-3320

Tennessee

Chattanooga
Chattanooga's Program in Women's Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Stephen Ernest DePasquale
Phone: 412-339-5294
Knoxville
University of Tennessee - Knoxville
Status: CLOSED_TO_ACCRUAL
Contact: Larry Clinton Kilgore
Phone: 865-544-9773

Texas

Austin
Dell Seton Medical Center at The University of Texas
Status: CLOSED_TO_ACCRUAL
Contact: James Stuart Ferriss
Phone: 512-324-7991
Texas Oncology - Central Austin Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 512-427-9400
Texas Oncology - South Austin Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 512-447-2202
Texas Oncology-Austin Midtown
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 512-421-4163
Bedford
Texas Oncology Bedford
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 817-359-9000
Conroe
MD Anderson in The Woodlands
Status: CLOSED_TO_ACCRUAL
Contact: Pamela Therese Soliman
Phone: 866-377-4321
Dallas
Parkland Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: David Scott Miller
Phone: 214-590-5582
Texas Health Presbyterian Hospital Dallas
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 214-345-8382
Texas Oncology at Baylor Charles A Sammons Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 888-864-4226
UT Southwestern / Simmons Cancer Center-Dallas
Status: CLOSED_TO_ACCRUAL
Contact: David Scott Miller
Phone: 214-648-7097
Fort Worth
Texas Oncology - Fort Worth Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 412-339-5294
Houston
Houston Methodist Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Aparna A. Kamat
Phone: 713-790-2700
Lyndon Baines Johnson General Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Pamela Therese Soliman
Phone: 713-566-5000
M D Anderson Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Pamela Therese Soliman
Phone: 713-792-3245
MD Anderson West Houston
Status: CLOSED_TO_ACCRUAL
Contact: Pamela Therese Soliman
Phone: 877-632-6789
Memorial Hermann Texas Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Joseph Anthony Lucci
Phone: 713-792-3245
Methodist Willowbrook Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Aparna A. Kamat
Phone: 412-339-5294
League City
MD Anderson League City
Status: CLOSED_TO_ACCRUAL
Contact: Pamela Therese Soliman
Phone: 412-339-5294
Longview
Texas Oncology-Longview Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 903-757-2122
Sugar Land
Houston Methodist Sugar Land Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Aparna A. Kamat
Phone: 281-242-2873
MD Anderson in Sugar Land
Status: CLOSED_TO_ACCRUAL
Contact: Pamela Therese Soliman
Phone: 877-632-6789
Texas Oncology Cancer Center Sugar Land
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 281-277-5200
The Woodlands
Texas Oncology-The Woodlands
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 888-864-4226
Tyler
Tyler Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 903-579-9800
Webster
Deke Slayton Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Michael A. Bookman
Phone: 520-797-4468

Utah

American Fork
American Fork Hospital / Huntsman Intermountain Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Xylina T. Gregg
Phone: 801-408-1347
Cedar City
Sandra L Maxwell Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Xylina T. Gregg
Phone: 801-408-1347
Logan
Logan Regional Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Xylina T. Gregg
Phone: 801-408-1347
Murray
Intermountain Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Xylina T. Gregg
Phone: 801-408-1347
Ogden
McKay-Dee Hospital Center
Status: CLOSED_TO_ACCRUAL
Contact: Xylina T. Gregg
Phone: 801-408-1347
Provo
Utah Valley Regional Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Xylina T. Gregg
Phone: 801-408-1347
Saint George
Dixie Medical Center Regional Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Xylina T. Gregg
Phone: 801-408-1347
Salt Lake City
Huntsman Cancer Institute / University of Utah
Status: CLOSED_TO_ACCRUAL
Contact: Theresa Louise Werner
Phone: 801-581-4477
LDS Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Xylina T. Gregg
Phone: 801-408-1347
Utah Cancer Specialists-Salt Lake City
Status: CLOSED_TO_ACCRUAL
Contact: Xylina T. Gregg
Phone: 801-408-1347

Vermont

Bennington
Southwestern Vermont Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Leslie R. DeMars
Phone: 800-639-6918
Berlin
Central Vermont Medical Center / National Life Cancer Treatment
Status: CLOSED_TO_ACCRUAL
Contact: Cheung Wong
Phone: 802-225-5400
Burlington
University of Vermont Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Cheung Wong
Phone: 802-656-4101
University of Vermont and State Agricultural College
Status: CLOSED_TO_ACCRUAL
Contact: Cheung Wong
Phone: 802-656-8990
Saint Johnsbury
Norris Cotton Cancer Center-North
Status: CLOSED_TO_ACCRUAL
Contact: Leslie R. DeMars
Phone: 802-473-4100

Virginia

Charlottesville
University of Virginia Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Susan Carnall Modesitt
Phone: 434-243-6322
Fairfax
Inova Schar Cancer Institute
Status: CLOSED_TO_ACCRUAL
Contact: Michael L. Maitland
Falls Church
Inova Fairfax Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Michael L. Maitland
Phone: 703-208-6650
Richmond
Henrico Doctor's Hospital
Status: CLOSED_TO_ACCRUAL
Contact: William Patrick McGuire
Phone: 412-339-5294
Virginia Commonwealth University / Massey Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: William Patrick McGuire
Virginia Gynecologic Oncology
Status: CLOSED_TO_ACCRUAL
Contact: William Patrick McGuire
Phone: 804-289-4902
Roanoke
Carilion Clinic Gynecological Oncology
Status: CLOSED_TO_ACCRUAL
Contact: Janet L. Osborne
Phone: 540-985-8510

Washington

Burien
Highline Medical Center-Main Campus
Status: CLOSED_TO_ACCRUAL
Contact: Mehmet Sitki Copur
Phone: 308-398-6518
Gig Harbor
MultiCare Gig Harbor Medical Park
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 907-458-5380
Seattle
Fred Hutchinson Cancer Research Center
Status: CLOSED_TO_ACCRUAL
Contact: Heidi Joy Gray
Phone: 800-422-6237
Northwest Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Heidi Joy Gray
Phone: 206-368-1608
Seattle Cancer Care Alliance
Status: CLOSED_TO_ACCRUAL
Contact: Heidi Joy Gray
Phone: 800-804-8824
University of Washington Medical Center
Status: CLOSED_TO_ACCRUAL
Contact: Heidi Joy Gray
Phone: 206-616-8289
Women's Cancer Center of Seattle
Status: CLOSED_TO_ACCRUAL
Contact: Heidi Joy Gray
Phone: 412-339-5294
Tacoma
MultiCare Tacoma General Hospital
Status: CLOSED_TO_ACCRUAL
Contact: John A. Keech
Phone: 907-458-5380

West Virginia

Huntington
Edwards Comprehensive Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Maria Rosalia B. Tria Tirona
Phone: 304-399-6617
Morgantown
Monongalia Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jamie L. Lesnock
Phone: 304-598-6560

Wisconsin

Chippewa Falls
Marshfield Clinic-Chippewa Center
Status: CLOSED_TO_ACCRUAL
Contact: Anthony C. Evans
Phone: 800-839-3956
Eau Claire
Marshfield Clinic Cancer Center at Sacred Heart
Status: CLOSED_TO_ACCRUAL
Contact: Anthony C. Evans
Phone: 800-839-3956
Green Bay
Green Bay Oncology Limited at Saint Mary's Hospital
Status: ACTIVE
Contact: Jonathan Edward Tammela
Phone: 920-433-8889
Green Bay Oncology at Saint Vincent Hospital
Status: ACTIVE
Contact: Jonathan Edward Tammela
Phone: 920-433-8889
Saint Vincent Hospital Cancer Center Green Bay
Status: CLOSED_TO_ACCRUAL
Contact: Jonathan Edward Tammela
Phone: 920-433-8889
Saint Vincent Hospital Cancer Center at Saint Mary's
Status: CLOSED_TO_ACCRUAL
Contact: Jonathan Edward Tammela
Phone: 412-339-5294
Madison
University of Wisconsin Hospital and Clinics
Status: CLOSED_TO_ACCRUAL
Contact: Lisa Marie Barroilhet
Phone: 800-622-8922
Manitowoc
Holy Family Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Jonathan Edward Tammela
Phone: 920-320-2749
Marshfield
Marshfield Medical Center-Marshfield
Status: CLOSED_TO_ACCRUAL
Contact: Anthony C. Evans
Phone: 715-389-4457
Milwaukee
Medical College of Wisconsin
Status: CLOSED_TO_ACCRUAL
Contact: William H. Bradley
Phone: 414-805-4380
Mukwonago
ProHealth D N Greenwald Center
Status: CLOSED_TO_ACCRUAL
Contact: Janet Gail Turner
Phone: 412-339-5294
Oconomowoc
ProHealth Oconomowoc Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Janet Gail Turner
Phone: 262-928-7878
Oconto Falls
Saint Vincent Hospital Cancer Center at Oconto Falls
Status: CLOSED_TO_ACCRUAL
Contact: Jonathan Edward Tammela
Phone: 920-433-8889
Rice Lake
Marshfield Medical Center-Rice Lake
Status: CLOSED_TO_ACCRUAL
Contact: Anthony C. Evans
Phone: 715-236-8100
Stevens Point
Marshfield Clinic Stevens Point Center
Status: CLOSED_TO_ACCRUAL
Contact: Anthony C. Evans
Phone: 855-829-8555
Sturgeon Bay
Green Bay Oncology - Sturgeon Bay
Status: ACTIVE
Contact: Jonathan Edward Tammela
Phone: 920-433-8889
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Status: CLOSED_TO_ACCRUAL
Contact: Jonathan Edward Tammela
Phone: 920-433-8889
Waukesha
ProHealth Waukesha Memorial Hospital
Status: CLOSED_TO_ACCRUAL
Contact: Janet Gail Turner
Phone: 262-928-7632
UW Cancer Center at ProHealth Care
Status: CLOSED_TO_ACCRUAL
Contact: Janet Gail Turner
Phone: 262-928-5539
Wausau
Aspirus Regional Cancer Center
Status: CLOSED_TO_ACCRUAL
Contact: Christopher Gary Peterson
Phone: 877-405-6866
Marshfield Clinic-Wausau Center
Status: CLOSED_TO_ACCRUAL
Contact: Anthony C. Evans
Phone: 800-847-0016
Weston
Marshfield Clinic - Weston Center
Status: CLOSED_TO_ACCRUAL
Contact: Anthony C. Evans
Phone: 715-393-1400
Wisconsin Rapids
Marshfield Clinic - Wisconsin Rapids Center
Status: CLOSED_TO_ACCRUAL
Contact: Anthony C. Evans
Phone: 800-656-0664

PRIMARY OBJECTIVES:

I. To determine if the addition of metformin (metformin hydrochloride) to the standard regimen of carboplatin and paclitaxel prolongs progression-free survival (PFS) in women with advanced or recurrent endometrial cancer. (Phase II)

II. To determine if the addition of metformin to the standard regimen of carboplatin and paclitaxel prolongs overall survival (OS) in the same population if a phase III study is conducted. Both clinical trials (Phase II and III) will utilize OS as a primary endpoint if a phase III trial is opened.

SECONDARY OBJECTIVES:

I. To estimate the proportion of patients with objective response (response rate [RR]) in the population of patients with measurable disease by treatment.

II. To estimate the duration of response in the population of patients with measurable disease who respond by treatment.

III. To estimate overall survival (OS) and relative hazards of death for each treatment arm if the study stops after the phase II trial is completed. If the study continues with a phase III clinical trial, then PFS will be a secondary endpoint.

IV. To determine the nature, frequency and degree of toxicity as assessed by Common Terminology Criteria for Adverse Events (CTCAE) for each treatment arm.

V. To estimate possible differences in RR, PFS, OS, and toxicity rates for the treatment regimens by the patients’ level of obesity.

TERTIARY OBJECTIVES:

I. To test whether PIK3CA mutations/amplifications, PTEN mutations or PIK3R1/PIK3R2 mutations have a lower hazard of progression or death (PFS endpoint) among patients who are treated with metformin.

II. To test whether higher expression of MATE 2 is associated with a lower hazard of progression or death (PFS endpoint) among patients who are treated with metformin.

III. To explore the association of metabolic factors (i.e. body mass index [BMI], hip-to-waist ratio, diabetes status, hemoglobin A1c [HgbA1C], fasting insulin and glucose levels, homeostatic model assessment [HOMA] scores) with treatment response to metformin/paclitaxel/carboplatin, PFS, and OS.

IV. To test whether genomic profiles (i.e. PIK3CA mutations/amplifications, PTEN mutations or PIK3R1/PIK3R2 mutations) differ between the tumors of obese and non-obese endometrial cancer (EC) patients.

V. To correlate expression of key targets of the insulin/IGF-1/mTOR signaling pathway (p-IGF1R, p-S6 and p-4EBP-1) with treatment response to metformin/paclitaxel/carboplatin, PFS, OS and obesity status.

VI. To determine if the genetic variants of the metformin transporters correspond with treatment response to metformin/paclitaxel/carboplatin, PFS and OS.

VII. To estimate differences in physical functioning, physical activity, and fatigue between treatment arms.

VIII. To explore the association between metabolic factors (i.e., BMI, hip-to-waist ratio, diabetes status, HgbA1C, fasting insulin and glucose levels, HOMA scores) and physical functioning, physical activity, and fatigue.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive paclitaxel intravenously (IV) over 3 hours on day 1, carboplatin IV over 30 minutes on day 1, and metformin hydrochloride orally (PO) twice daily (BID) (approximately 10-12 hours apart) on days 1-21 (once daily [QD] in course 1). Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then receive maintenance therapy comprising metformin hydrochloride PO BID on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive paclitaxel IV and carboplatin IV as in Arm I. Patients also receive placebo PO BID (approximately 10-12 hours apart) on days 1-21 (QD in course 1). Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then receive maintenance therapy comprising placebo PO BID on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

In both arms, patients who achieve stable disease (SD) or partial response (PR) and still have measurable disease at the completion of course 6 may continue to receive paclitaxel IV and carboplatin IV (with metformin hydrochloride or placebo) for an additional 4 courses at the discretion of the treating investigator.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Trial Phase Phase II/III

Trial Type Treatment

Lead Organization
NRG Oncology

Principal Investigator
Victoria Lin Bae-Jump

  • Primary ID GOG-0286B
  • Secondary IDs NCI-2013-02284, s14-01068
  • Clinicaltrials.gov ID NCT02065687