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Case Report Forms

Human Cancer Models Initiative's (HCMI) cancer type specific case report forms (CRFs) have been developed through collaborations with international clinical experts and the clinical data elements have been standardized through the Cancer Data Standards Registry and Repository (caDSR). As the tumor types modeled through the HCMI are constantly updated, be sure to check back regularly for additional or updated CRFs.

Please note that in some cases, it is possible to collect tissues from different tumor sites (e.g., primary, metastatic, or recurrent) from the same patient for model development. New CRFs capture information about multiple models developed from the same patient within a single form. The multiple model CRFs are designated with "-multi" within the file name. Versioning is used if there are any subsequent edits to the CRFs.  

The cancer types that are not highly represented in the HCMI models are considered “rare” by HCMI, however, they may not be considered “rare” based on their representation among cancer incidence rates. The “Rare Cancer CRFs” are being used to capture clinical data for these cancer types: Bladder Cancer, Chordoma, Epithelioid Sarcoma, Extrahepatic Cholangiocarcinoma, Gallbladder Cancer, Spindle Cell Sarcoma, Small Intestine Cancer, and Thyroid Cancer.  

Enrollment Forms

The enrollment CRFs data are collected at the time of patient index date, which includes initial pathologic diagnosis, sample procurement, or first patient visit.

Follow-up Forms

The follow-up CRF data are collected at least 3 months after enrollment data collection following model establishment.

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