Omega-3 Fatty Acids in Preventing Recurrence in Patients with Hormone Receptor-Negative or HER2-Positive Stage 0-III Breast Cancer That Have Completed Treatment

Inclusion Criteria

• Prior diagnosis of stage 0 to III breast cancer that is estrogen receptor negative, progesterone receptor negative with completion of definitive surgery, radiation therapy and/or chemotherapy
• Completion of chemotherapy for > six months, trastuzumab for > 3 months and radiation therapy for >= 2 months, as applicable and 5 years or less from completion of standard therapy
• Greater than 1 year from pregnancy, lactation
• Mammogram performed or reviewed by an Ohio State University (OSU) radiologist at the Stefanie Spielman Comprehensive Breast Center or the James Cancer Hospital within the six months prior to study enrollment that are not suspicious for breast cancer (American College of Radiology [ACR] class I-III); subjects with a class IV mammogram may be entered following a negative biopsy
• Must be willing to undergo fine needle aspiration of the contralateral breast for breast adipose tissue at 0, 3, 6, 9 and 12 months of the study and breast epithelial tissue samples at 0, 6 and 12 months of study
• Must be willing to have about 30 ml of blood drawn at 0, 6 and 12 months and about 5-10 ml of blood at 3 and 9 months
• No history of diabetes mellitus or stroke, or bleeding tendency
• Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 (fully active or restricted only in physically strenuous activity)
• Hemoglobin >= 9 g/dL
• Platelets >= 100,000/mm^3
• Fasting blood glucose =< 115 mg/dL
• Transaminases (aspartate aminotransferase [AST], alanine aminotransferase [ALT]) =< 1.5 x upper limit of normal (ULN)
• Negative pregnancy test for women of childbearing potential

Exclusion Criteria

• Other current malignancy or metastatic malignancy of any kind, with exception of non-melanoma skin cancer or carcinoma in situ of the cervix
• Ongoing chemotherapy, radiation therapy, or other cancer-related treatment
• Subjects on Coumadin or other anticoagulants
• Subjects with breast implants
• Subjects who have had radiation to both breasts or who have undergone bilateral mastectomies
• Subjects with insufficient breast adipose tissue and/or parenchymal breast tissue/breast density for adequate FNA sampling as determined by clinical examination and/or mammography
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, hypertension, or psychiatric illness/social situation that would limit compliance with study requirements
• Chronic use of omega-3 fatty acid concentrates or capsules within the 3 months prior to entry on the study or any other supplements that might interact with omega-3 fatty acid supplements
• Pregnant or nursing women
• Known sensitivity or allergy to fish
• Subjects on a standing regimen of full dose aspirin (>= 325 mg/day), nonsteroidal anti-inflammatory drugs (NSAIDs) or NSAID-containing products
• Vegetarians or subjects allergic to specific oils in the study capsules e.g. soybean oil