Ponatinib Hydrochloride in Treating Patients with Bevacizumab-Refractory Glioblastoma

Inclusion Criteria

• Karnofsky performance status >= 60
• Participants must have histologically confirmed glioblastoma or variants; subjects with initial diagnosis of a lower grade glioma are eligible if a subsequent biopsy is determined to be glioblastoma or variants
• Patients must have an unequivocal progression by magnetic resonance imaging (MRI) or computed tomography (CT) scan; a scan must be performed within 14 days prior to registration and on a steroid dose that has been stable or decreasing for at least 5 days; if the steroid dose is increased between the date of imaging and initiation of study treatment, a new baseline MRI/CT is required
• Participants must have bi-dimensionally measurable disease with a minimum measurement of 1 cm per dimension on MRI performed within 14 days prior to registration; if receiving corticosteroids, participants must be on a stable or decreasing dose of corticosteroids for at least 5 days prior to baseline MRI
• There is no limit on the number of prior relapses but the most recent relapse must be the first relapse on a bevacizumab-containing regimen
• Leukocytes >= 3,000/mcL (>= 3,000/mm^3)
• Absolute neutrophil count >= 1,500/mcL (>= 1,500/mm^3)
• Platelets >= 100,000/mcL (>= 100,000/mm^3)
• Total bilirubin =< 1.5 x institutional upper limit of normal, unless due to Gilbert’s syndrome
• Aspartate aminotransferase (AST) (serum glutamic transaminase ([SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional upper limit of normal
• Serum creatinine =< 1.5 x institutional upper limit of normal or creatinine clearance > 60 mL/min/1.73 m^2 (per 24 hour urine collection or calculated according to the Cockcroft-Gault formula) for subjects with creatinine levels above the institutional normal
• Serum lipase =< 1.5 x institutional upper limit of normal
• Serum amylase =< 1.5 x institutional upper limit of normal
• Participants must have fully recovered (grade =< 1 or baseline or deemed irreversible) from any clinically significant acute toxicity related to prior therapy (with the exception of lymphopenia, which is common after therapy with temozolomide); patients who discontinued bevacizumab previously due to a bevacizumab-related toxicity will not be allowed to participate
• The following time periods must have elapsed prior to the planned start date of study treatment: * >= 2 weeks or 6 half-lives from any approved tyrosine kinase inhibitors (TKIs) or investigational agent, whichever is shorter * >= 4 weeks from prior cytotoxic therapy, except >= 3 weeks from last dose of temozolomide and >= 6 weeks from nitrosoureas or mitomycin C * >= 2 weeks from non-cytotoxic agents * >= 3 weeks from bevacizumab
• Participants must have developed progressive disease after receiving prior radiation therapy and must have an interval of at least 12 weeks from the completion of any radiation therapy to study entry (unless progressive tumor growth is outside the radiation field or there is histopathological confirmation of recurrent tumor)
• Participants may not have received prior therapy with any other Src, platelet-derived growth factor receptors (PDGFR), or fibroblast growth factor receptors (FGFR) inhibitor; prior treatment with an anti-vascular endothelial growth factor receptor (VEGFR) or anti-vascular endothelial growth factor (VEGF) agent is also allowed but only one relapse following a bevacizumab-containing regimen is allowed
• For women of childbearing potential (defined as women with menses within the past 2 years), a negative serum pregnancy test must be documented prior to registration; NOTE: in addition to screening, serum pregnancy test must be performed on females of childbearing potential within 72 hours before the start of investigational product; when possible, these tests can be one-in-the-same (if screening pregnancy test was performed within 72 hours of first ponatinib dose, no need to repeat)
• Women of child-bearing potential (defined as women with menses within the past 2 years) and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and through 4 months after the end of treatment; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately
• Ability to understand and the willingness to sign a written informed consent document; NOTE: consent documents can be signed up to 30 days prior to registration; if > 30 days has elapsed since patient signed the consent document, s/he must re-consent (new signature) before proceeding to register onto study
• Participants must have sufficient tissue from prior surgery revealing glioblastoma or variants for confirmation of diagnosis and correlative studies; the following amount of tissue is required: * 15 (5 um thick) unstained formalin fixed paraffin embedded (FFPE) sections * 1-2 hematoxylin and eosin (H&E) stained slides, or additional unstained 5 um slide(s) for staining * NOTE: the overall principal investigator (PI) will allow for up to 2 participants to enroll with insufficient tissue; if a site is hoping to enroll a patient with less than the tissue required, prospective approval by the overall PI is required
• Protocol treatment plan must include beginning therapy within 5 consecutive days after registration

Exclusion Criteria

• Participants may not be receiving any other investigational agents
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to ponatinib
• Participants who have received prior treatment with interstitial brachytherapy, stereotactic radiosurgery, or implanted chemotherapy sources, such as wafers of polifeprosan 20 with carmustine
• Participants with poorly controlled diabetes defined as a hemoglobin A1c (HgbA1c) >= 7.0%
• Participants with grade >= 3 peripheral motor or sensory neuropathy
• Participants receiving any medications or substances that are moderate and strong inhibitors or inducers of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4), including enzyme-inducing anti-epileptic drugs (EIAEDs) within 14 days before the first dose of ponatinib will be excluded; this category includes phenobarbital, phenytoin, fosphenytoin, primidone, carbamazepine, and oxcarbazepine * NOTE: participants must avoid consumption of Seville orange (and juice), grapefruit or grapefruit juice, grapefruit hybrids, pummelos and exotic citrus fruits from 7 days prior to the first dose of study drug and during the entire study treatment period
• Participants taking medications that are known to be associated with torsades de pointes or QT prolongation within 14 days of starting treatment
• Participants cannot take any herbal preparations/medications on study or within 7 days prior to first dose of study drug, including but not limited to: St. John‘s wort, kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, ginseng
• Participants who underwent major surgery (including craniotomy) or significant traumatic injury within 28 days prior to initiating therapy; baseline MRIs for participants who underwent salvage surgery must be obtained within 14 days of registration (similar to other patients who do not have surgery) and there must be measurable disease
• Participants who underwent minor surgical procedure within 7 days prior to initiating therapy
• History of a bleeding disorder
• Patients with gastrointestinal bleeding or any other hemorrhage/bleeding event Common Terminology Criteria for Adverse Events (CTCAE) grade >= 3 within 30 days prior to study entry
• Patients whose screening MRI scan demonstrates intratumoral hemorrhage or peritumoral hemorrhage are not eligible for treatment if deemed significant by the treating physician
• History of acute pancreatitis within 1 year of study treatment or a history of chronic pancreatitis
• History of alcohol abuse
• Uncontrolled hypertriglyceridemia (triglycerides > 450 mg/dL)
• Clinically significant, uncontrolled, or active cardiovascular disease, specifically including, but not restricted to: * Any history of myocardial infarction * Any history of clinically significant (as determined by the treating physician) atrial arrhythmia * Any history of ventricular arrhythmia * Any history of cerebrovascular accident or transient ischemic attack (TIA) * Any history of peripheral arterial occlusive disease requiring revascularization * Unstable angina within 6 months prior to enrollment * Congestive heart failure within 6 months prior to enrollment * Venous thromboembolism including deep venous thrombosis or pulmonary embolism within 6 months prior to enrollment * Unacceptable screening baseline cardiovascular assessment: ** Baseline multi gated acquisition scan (MUGA) (to be done within 30 days of registration) or echocardiogram demonstrating left ventricular ejection fraction (LVEF) < 50 % ** Corrected QT (QTc) >= 480 msec on screening electrocardiogram (ECG) (using the QTc Fridericia [QTcF] formula)
• Uncontrolled hypertension (diastolic blood pressure > 90 mm Hg; systolic > 140 mm Hg); patients with hypertension should be under treatment on study entry to effect blood pressure control
• Ongoing or active infection; the requirement for intravenous (IV) antibiotics is considered active infection
• Known history of human immunodeficiency virus (HIV); testing is not required in the absence of prior documentation or known history; HIV-positive individuals on combination antiretroviral therapy are ineligible
• Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with ponatinib
• Malabsorption syndrome or other gastrointestinal illness that could affect oral absorption of study drugs
• Individuals with a history of a different malignancy, other than cervical cancer in situ, basal cell or squamous cell carcinoma of the skin, are ineligible, except if they have been disease-free for at least 5 years, and are deemed by the investigator to be at low risk for recurrence of that malignancy OR if the other primary malignancy is neither currently clinically significant nor requiring active intervention
• Any condition or illness that, in the opinion of the investigator, would compromise patient safety or interfere with the evaluation of the drug