Skip to main content
An official website of the United States government

Fluorine F 18 Fluorthanatrace Biodistribution, Metabolism and Excretion Analysis in Patients with Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Trial Status: temporarily closed to accrual

This pilot phase I trial studies fluorine 18 (F 18) fluorthanatrace biodistribution (to see how it is taken up in the body), metabolism and excretion analysis in patients with ovarian, fallopian tube or primary peritoneal cancer. Fluorine F 18 fluorthanatrace is a radioactive substances that are absorbed by cancerous cells and allow for the cancer to be found using diagnostic procedures such as positron emission tomography (PET) and computed tomography (CT). Poly adenosine diphosphate ribose polymerase (PARP-1) is an enzyme that helps regulate cell process, such as cell growth, cell death and detect deoxyribonucleic acid (DNA) damage. Fluorine F 18 fluorthanatrace may be used to detect PARP-1 activity in tumors. Imaging PARP-1 activity in patients with ovarian, fallopian tube or primary peritoneal cancer may help doctors understand its function and determine the best way to use imaging to help study new treatments that target the PARP-1 enzyme.