Dasatinib in Treating Patients with nEGFR Positive Stage I-III Triple-Negative Breast Cancer
This phase II trial studies how well dasatinib works in treating patients with nuclear (n)EGFR stage I-III triple-negative breast cancer. nEGFR promotes tumor growth. Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Inclusion Criteria
- ELIGIBILITY CRITERIA FOR nEGFR TESTING
- Patients must have histologically or cytologically confirmed stage I-III triple negative breast cancer * Estrogen receptor (ER) and progesterone receptor (PR) must be < 10% by standard assay methods * Human epidermal growth factor receptor 2 (HER2) must be either 0, 1+ by immunohistochemistry (if 2+, in situ hybridization method used to define HER2) OR have HER2: 17 centromere signal of < 2.0 using a standard in situ hybridization method
- No prior therapy for current breast cancer
- Meet criteria for neoadjuvant chemotherapy or primary breast surgery, as determined by primary oncologist and surgeon
- ELIGIBILITY CRITERIA FOR STUDY THERAPY
- nEGFR positive
- Eastern Cooperative Oncology Group (ECOG) performance status =< 1
- Leukocytes >= 3,000/mcL
- Absolute neutrophil count >= 1,500/mcL
- Platelets >= 150,000/mcL
- Total bilirubin < 1.25 x institutional upper limit of normal
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional upper limit of normal
- Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal
- Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation and for 30 days after the final dose; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
- Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria
- Patients who are receiving any other investigational agents
- Patients not able to swallow oral medications or with gastrointestinal conditions that may impact absorption of dasatinib
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to dasatinib
- Patients receiving any medications or substances that are moderate or strong inhibitors or inducers of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) are ineligible; as part of the enrollment/informed consent procedures, the patient will be counseled on the risk of interactions with other agents, and what to do if new medications need to be prescribed or if the patient is considering a new over-the-counter medicine or herbal product
- Histamine 2 (H2) antagonists and proton pump inhibitors are not allowed
- Anticoagulants (i.e. Coumadin, heparin, anti-Xa inhibitors) and anti-platelet agents (i.e. aspirin) are not allowed; nonsteroidal anti-inflammatory drugs (NSAIDS) and acetaminophen are allowed on study
- Medications known to prolong corrected QT (QTC) are not allowed
- No history of prolonged QTC or cardiomyopathy unless normal QTC and ejection fraction confirmed within 1 month prior to study entry
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Pregnant women are excluded from this study because dasatinib is a pregnancy category D agent with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with dasatinib, breastfeeding should be discontinued if the mother is treated with dasatinib and not resumed until at least 2 weeks after the final dose
- Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with dasatinib; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated
- Contraindication to repeat breast biopsy (neoadjuvant chemotherapy group)
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT02720185.
PRIMARY OBJECTIVE:
I. To determine if dasatinib, an inhibitor of the Src family kinases, can prevent the nuclear translocation of the epidermal growth factor receptor (EGFR) in stage I-III nuclear EGFR positive, triple-negative breast cancers (TNBC).
SECONDARY OBJECTIVES:
I. To examine the safety and tolerability of dasatinib in patients with operable TNBC.
II. To explore potential intracellular mechanisms which impact dasatinib effect on cellular localization of EGFR in operable TNBC.
III. To examine the pathologic complete response (pCR) rates to standard neoadjuvant chemotherapy in nEGFR+ TNBC.
IV. To examine breast cancer recurrence rates and patterns of metastatic recurrence in nEGFR+ TNBC.
OUTLINE:
Patients receive dasatinib orally (PO) once daily (QD) on days 1-10 in the absence of disease progression or unacceptable toxicity and then undergo surgery.
After completion of study treatment, patients are followed up for 30 days and then every 4-6 months for up to 2 years.
Trial PhasePhase II
Trial Typebasic science
Lead OrganizationUniversity of Wisconsin Carbone Cancer Center - University Hospital
Principal InvestigatorKari Braun Wisinski
- Primary IDUW15114
- Secondary IDsNCI-2016-00237, 2015-1578
- ClinicalTrials.gov IDNCT02720185