PET Imaging with 18F-FSPG in Detecting Tumors in Patients with Advanced Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer

Inclusion Criteria

• Adult patients who have a presumed diagnosis of advanced stage epithelial ovarian, fallopian tube, or peritoneal * Pelvic mass and/or omental caking with Ca-125:carcinoembryonic antigen (CEA) ratio 25:1
• Adequate performance status, Eastern Cooperative Oncology Group (ECOG) 0, 1, 2
• Packed cell volume (PCV) >= 30 (with or without transfusion)
• White blood cell (WBC): 3000 – 10,000
• Platelet count >= 150, 000 and < 1,000,000
• Creatinine (Cr) =< 1.5
• Liver function tests (LFTS) =< 1.5 x upper limit of normal (ULN)
• Patients will have undergone or have agreed to undergo standard of care CT of the chest, abdomen, and pelvis; 18F-FSPG PET imaging will be performed as investigational studies
• No prior treatment for ovarian cancer
• Have undergone or agree to undergo standard of care imaging for ovarian cancer with CT chest, abdomen, and pelvis

Exclusion Criteria

• Patients who have non-invasive or non-epithelial ovarian cancer on pathological confirmation; patients with synchronous stage I endometrial cancer will not be excluded
• Pregnant and breastfeeding patients
• Patients with poorly controlled diabetes mellitus (fasting blood glucose level > 200 mg/dL)
• Patients with other poorly controlled medical conditions that in the opinion of the surgeon, make them not a candidate for primary cytoreductive surgery
• Patients will be deemed not candidates for surgical resection and therefore ineligible for this study based on imaging criteria alone, if CT chest, abdomen, pelvis demonstrates: * Any disease in the thoracic cavity >= 1 cm * Any suprarenal lymphadenopathy >= 1 cm * Liver metastases >= 1 cm * Disease in the porta hepatis or gallbladder fossa >= 1 cm * Pleural effusion >= 50% volume of the chest cavity on chest x-ray * Omental extension to the stomach, spleen, or lesser sac * Extension to the pelvic sidewall (this criteria may also be assessed on physical examination * Involvement of the root of the mesentery
• Patient declines procedures that might be necessary for optimal primary cytoreduction (i.e. colostomy or splenectomy)