A Study of INCAGN01876 in Participants With Advanced or Metastatic Solid Tumors

Inclusion Criteria

• Locally advanced or metastatic disease; locally advanced disease must not be amenable to resection with curative intent.
• Part 1: Participants with advanced or metastatic solid tumors.
• Part 2: Participants with advanced or metastatic adenocarcinoma of endometrium, melanoma, non-small cell lung cancer, and renal cell carcinoma.
• Participants who have disease progression after treatment with available therapies that are known to confer clinical benefit, or who are intolerant to treatment, or participants who refuse standard treatment.
• Presence of measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.
• Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1.

Exclusion Criteria

• Laboratory and medical history parameters not within the protocol-defined range.
• Receipt of anticancer medications or investigational drugs within protocol-defined intervals before the first administration of study drug.
• Has not recovered to ≤ Grade 1 from toxic effects of prior therapy and/or complications from prior surgical intervention before starting therapy.
• Receipt of a live vaccine within 30 days of planned start of study therapy.
• Active autoimmune disease.
• Prior treatment with any tumor necrosis factor super family agonist.
• Known active central nervous system metastases and/or carcinomatous meningitis.
• Evidence of active, non-infectious pneumonitis or history of interstitial lung disease.
• Evidence of hepatitis B virus or hepatitis C virus infection or risk of reactivation.