This randomized clinical trial studies how well high-intensity interval training or moderate-intensity continuous training works in preventing breast cancer in high risk patients. High-intensity interval training or moderate-intensity continuous training may help to lower biomarker levels that are linked to breast cancer risk and lead to a healthier lifestyle.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT02923401.
PRIMARY OBJECTIVES:
I. To assess levels of patient eligibility, consent, adherence, and retention for high-intensity interval exercise compared to moderate continuous exercise.
II. To assess the effect size of high-intensity exercise on cardiorespiratory fitness, circulating biomarkers, and quality of life surveys in women at high-risk for breast cancer.
OUTLINE: Patients are randomized to 1 of 3 groups.
GROUP I: Patients undergo high-intensity interval training (HIIT) over 33 minutes, 3 times a week for 12 weeks. Patients also undergo a motivational interviewing session over 15-30 minutes once a month for 3 months.
GROUP II: Patients undergo moderate-intensity continuous training (MICT) over 41 minutes, 3 times a week for 12 weeks. Patients also undergo a motivational interviewing session over 15-30 minutes once a month for 3 months.
GROUP III: Patients receive standard of care written information regarding healthy eating and engaging in regular physical activity. Patients also receive a phone call over 15 minutes once a month for 3 months to discuss progress regarding personal goals towards healthy lifestyle change.
Trial PhaseNo phase specified
Trial Typeprevention
Lead OrganizationM D Anderson Cancer Center
Principal InvestigatorSusan C Gilchrist
