Abemaciclib, DNA-PK/TOR Kinase Inhibitor CC-115, Neratinib, or QBS10072S in Treating Patients with Brain Tumors after Biomarker Screening

Inclusion Criteria

• Participants must have histologically confirmed intracranial glioblastoma or gliosarcoma following maximum surgical resection; tumors primarily localized in the infratentorial compartment will be excluded * Participants with histology of astrocytoma with molecular alterations/features indicative of glioblastoma (World Health Organization [WHO] grade IV) will be eligible
• Participants may have had prior surgery for glioblastoma or gliosarcoma but no systemic therapy, interstitial chemotherapy (e.g., Gliadel wafers), or radiation therapy. Participants must be recovered from the effects of surgery
• Age >= 18 years
• Karnofsky performance status >= 60
• Leukocytes >= 3,000/mL (>= 3 x 10^9/L)
• Absolute neutrophil count >= 1,500/mL (>= 1.5 x 10^9/L)
• Platelets >= 100,000/uL (>= 100 x 10^9/L)
• Hemoglobin >= 9 g/dl
• Total bilirubin within normal institutional limits (except for participants with Gilbert’s disease)
• Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional upper limit of normal
• Creatinine =< institutional upper limit of normal OR
• Creatinine clearance >= 60 mL/min/1.73 m^2 for participants with creatinine levels above institutional normal
• Potassium within normal institutional range, or correctable with supplements
• Serum amylase =< 1.5 x institutional upper limit of normal
• Serum lipase =< 1.5 x institutional upper limit of normal
• International normalized ratio (INR) < 2.0
• Partial thromboplastin time (PTT) =< institutional upper limit of normal, unless receiving therapeutic low molecular weight heparin
• Must be able to swallow pills
• Corticosteroid (dexamethasone or equivalent) dosage =< 2 mg daily that has been stable or decreasing for at least 5 days
• Participants must plan to begin radiation therapy 14-42 days after surgical resection * NOTE: Patients may be allowed to begin radiation therapy > 42 days after surgical resection provided documented approval is obtained by Dr. Reardon - the study’s overall principal investigator (PI) - PROSPECTIVELY
• Immunohistochemically negative for IDH1 R132H mutation
• Evidence that the tumor MGMT promoter is unmethylated by standard of care assays. Genotyping data available or in process. 14 USS + 1 H&E will be collected. Confirmation of tissue availability is required for eligibility, but slides can be collected at a later date. * NOTE: Patients who do not have sufficient tissue, or when obtaining the requested samples requires depletion of a patient’s formalin-fixed paraffin-embedded (FFPE) block(s), may be eligible provided there is documentation of inadequate tissue AND documented approval is obtained by Dr. Reardon - the study’s overall PI - PROSPECTIVELY. All efforts should be made to obtain the maximum number of slides possible, even when prospective approval is granted
• Magnetic resonance imaging (MRI) with gadolinium should be obtained within 21 days prior to beginning treatment; patients without measurable disease are eligible; participants must be able to undergo MRIs (computed tomography scans [CTs] are not allowed for response assessment on study)
• The effects of the experimental agents used in this study on the developing human fetus are unknown; for this reason and because other therapeutic agents used in this trial are known to be teratogenic, women of child-bearing potential (women who are not free from menses for > 2 years, post hysterectomy/oophorectomy, or surgically sterilized) and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation unless otherwise specified in sub-study appendix that the participant is randomized to; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
• For women of child-bearing potential (women who are not free from menses for > 2 years, post hysterectomy/oophorectomy, or surgically sterilized) a negative serum pregnancy test must be documented prior to initial registration; women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) from date of initial dose and for 6 months following the last dose of study drug; men (including those who have had a vasectomy) must agree to use barrier contraception (latex condoms) when engaging in sexual activity with a woman of child-bearing potential from date of initial dose and for 6 months following the last dose of study drug
• Ability to understand and the willingness to sign a written informed consent document
• Eligibility criteria specific to the control arm: * Participants must be willing and able to provide written informed consent/assent for the control arm of the INdividualized Screening trial of Innovative Glioblastoma Therapy (INSIGhT) trial
• Eligibility criteria specific to the abemaciclib arm: * Participants must be willing and able to provide written informed consent/assent for the abemaciclib arm of the INSIGhT trial * Women of child bearing potential (women who are not free from menses for > 2 years, post hysterectomy/oophorectomy, or surgically sterile) and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) from date of initial dose and for 3 months following the last dose of abemaciclib
• Eligibility criteria specific to the CC-115 arm: * Participants must be willing and able to provide written informed consent for the CC-115 arm of the INSIGhT trial * Women of child bearing potential (women who are not free from menses for > 2 years, post hysterectomy/oophorectomy, or surgically sterile) must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) from date of initial dose and for 28 days following the last dose of CC-115; men (including those who have had a vasectomy) must agree to use barrier contraception (latex condoms) when engaging in sexual activity with a woman of child bearing potential from date of initial dose and for 28 days following the last dose of CC-115
• Eligibility criteria specific to the neratinib arm: * Participants must be willing and able to provide written informed consent/assent for the neratinib arm of the INSIGhT trial * Women of child bearing potential (women who are not free from menses for > 2 years, post hysterectomy/oophorectomy, or surgically sterile) must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) from date of initial dose and for 28 days following the last dose of neratinib; men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) during intercourse with women of childbearing potential from date of initial dose and for 3 months following the last dose of CC-115

Exclusion Criteria

• Participants will not be eligible if the original diagnosis was a lower grade glioma and a subsequent histologic diagnosis revealed glioblastoma
• Planned major surgery
• Participants who are receiving any other investigational agents
• Participants who have had any prior cranial radiotherapy
• Participants with a second invasive malignancy that is A) incompletely treated or requiring ongoing treatment, or B) reasonably anticipated to be associated with a median overall survival of less than 1 year based on population-level data for the specified disease site and stage
• History of intratumoral or peritumoral hemorrhage if deemed significant by the treating physician
• Impaired cardiac function or clinically significant cardiac diseases, including any of the following: * Active uncontrolled cardiac disease, including cardiomyopathy, congestive heart failure (New York Heart Association functional classification of >= 2), unstable angina, myocardial infarction within 12 months of enrollment, or ventricular arrhythmia * Known history of congenital QT prolongation or Torsade de pointes (TdP) * Complete left bundle branch or bifascicular block * Corrected QT by Fridericia's Correction Formula (QTc-f) interval > 450 ms for men or > 470 ms for women * History of clinically meaningful ventricular arrhythmias or atrial fibrillation * Unstable pectoris or myocardial infarction =< 3 months prior to starting study treatment * Uncontrolled hypertension (blood pressure >= 160/95 mmHg) * Other clinically significant heart disease such as congestive heart failure requiring treatment
• Uncontrolled diabetes mellitus, or subjects with either of the following: * Blood glucose >= 200 mg/dL (7.0 mmol/L), or * Glycosylated hemoglobin measurement (HbA1c) >= 8% * NOTE: HbA1c is not a required screening lab; however, if HbA1C is performed at screening, result must be < 8% * NOTE: If patient’s HbA1c is >= 8%, team may proceed to register patient with documented explanation (e.g. patient has controlled Type 2 diabetes mellitus, but steroid dose at time of screening labs has elevated result) and documented confirmation from treating MD that they feel patient is safe to proceed
• Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, chronic liver disease (e.g., cirrhosis, hepatitis), chronic renal disease, pancreatitis, chronic pulmonary disease, or psychiatric illness/social situations that would limit compliance with study requirements; subjects must be free of any clinically relevant disease (other than glioma) that would, in the treating investigator’s opinion, interfere with the conduct of the study or study evaluations. Participants with vitiligo, or hypothyroidism due to autoimmune condition only requiring hormone replacement therapy, psoriasis not requiring systemic therapy, or conditions not expected to recur in the absence of an external trigger are permitted to enroll
• Known immunosuppressive disease or active systemic autoimmune disease such as systemic lupus erythematosus, human immunodeficiency virus infection. Known active hepatitis B (e.g., hepatitis B surface antigen [HBsAg] reactive) or hepatitis C (e.g., hepatitis C virus [HCV] RNS [qualitative] is detected)
• Known acute or chronic pancreatitis
• Participants with active diarrhea >= Common Terminology Criteria for Adverse Events (CTCAE) grade 2 despite medical management
• Active infection requiring antibiotics
• Pregnant or breastfeeding
• Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of study drug (e.g., ulcerative diseases, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or extensive small bowel resection); participants with unresolved diarrhea >= CTCAE grade 2 will be excluded as previously indicated
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to any of the experimental agents or other agents used in study
• Participants taking an enzyme-inducing anti-epileptic drug (EIAED): phenobarbital, phenytoin, fosphenytoin, primidone, carbamazepine, oxcarbazepine, eslicarbazepine, rufinamide, and felbamate; participant must be off any EIAEDs for at least 7 days prior to planned start of study investigational agent, excluding Temodar; among non-EIAED, caution is recommended with use of valproic acid due to potential for drug interaction
• Participants taking a drug known to be strong inhibitors or inducers of isoenzyme CYP3A; participant must be off CYP3A inhibitors and inducers for at least 7 days prior to planned start of study treatment; NOTE: participants must avoid consumption of Seville orange (and juice), grapefruit or grapefruit juice, grapefruit hybrids, pummelos and exotic citrus fruits from 7 days prior to planned start of study treatment and during the entire study treatment period due to potential CYP3A4 interaction
• Current use of herbal preparations/medications, including but not limited to: St. John’s wort, kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, ginseng; participants should stop using these herbal medications 7 days prior to planned start of study treatment
• Current use of warfarin sodium or any other coumadin-derivative anticoagulant; participant must be off coumadin-derivative anticoagulants for at least 7 days prior to planned start of study treatment; low molecular weight heparin and factor Xa inhibitors are allowed
• Participants who may have experienced prior immune-mediated adverse events (e.g., life-threatening pneumonitis)