Whole Pelvis Radiation Therapy and Stereotactic Body Radiation Therapy in Reducing Treatment-Related Post-traumatic Stress in Patients with Stage IB-IVB Cervical Cancer Who Refuse or Are Medically Unable to Receive Brachytherapy

Inclusion Criteria

• Biopsy-proven, invasive carcinoma of the cervix
• Candidate for pelvic, pelvic-inguinal, or extended field radiotherapy with or without concurrent chemotherapy; patients undergoing preoperative or adjuvant chemotherapy are excluded
• Patient has either metastatic disease (M1; stage IVB), is medically unable to receive brachytherapy, or refuses brachytherapy
• History/physical examination within 60 days prior to registration to document cervical tumor size and stage
• Computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET)/CT imaging of the chest, abdomen, and pelvic regions within 60 days prior to registration (for stage I patients, posteroanterior [PA] and lateral chest x-ray is sufficient for chest imaging)
• Negative serum pregnancy test for women of child-bearing potential
• Women of childbearing potential must agree to practice effective birth control throughout their participation in the treatment phase of the study
• Patients must sign informed consent prior to study entry

Exclusion Criteria

• Prior radiotherapy to the pelvis or abdomen that would result in overlap of radiation therapy fields
• Prior hysterectomy
• Women who are pregnant or lactating are ineligible due to teratogenic effects on developing fetuses; women who are of child-bearing potential need to practice effective methods of contraception including oral contraceptives, intrauterine device, diaphragm with spermicides, and/or abstinence
• Patients undergoing preoperative or adjuvant chemotherapy
• History of pre-existing post-traumatic stress disorder (PTSD)
• History of major psychiatric disorder including use of anti-depressive medications, mood stabilizers, or anti-psychotic drugs