Ketogenic Diet in Evaluating Metabolomic and Tissue Effects in Overweight or Obese Patients with Stage I-IVB Endometrial Cancer

Inclusion Criteria

• Patients must have a diagnosis of endometrial carcinoma on a tissue sample obtained at MSK or WCMC (biopsy); patients with the following histologic epithelial cell types are eligible: endometrioid adenocarcinoma, serous adenocarcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, mixed epithelial carcinoma, adenocarcinoma not otherwise specified (N.O.S.), mucinous adenocarcinoma, squamous cell carcinoma, transitional cell carcinoma, carcinosarcoma
• Age >= 18 years
• Patients must have consented to surgery with a board-certified gynecology (Gyn) surgeon
• Patients must have not had adjuvant therapy for the management of endometrial carcinoma; this includes chemotherapy, chemotherapy and radiation therapy, and/or consolidation/maintenance therapy; chemotherapy administered in conjunction with primary radiation as a radio-sensitizer WILL be counted as a systemic chemotherapy regimen; this also pertains to hormonal, vascular, and targeted therapy for the management of endometrial cancer
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• Patients with stage I-IVB are eligible
• Absolute neutrophil count (ANC) >= 1.5 k/mcl (obtained within 11 days prior to first study treatment)
• Platelet count >= 100 k/mcl (obtained within 11 days prior to first study treatment)
• Hemoglobin >= 9.0 g/dL (obtained within 11 days prior to first study treatment)
• Total bilirubin =< 1.5 x the upper limit of normal (ULN) (obtained within 11 days prior to first study treatment)
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x ULN (obtained within 11 days prior to first study treatment)
• Albumin >= 3.5 g/dL (obtained within 11 days prior to first study treatment)
• Serum creatinine =< 1.5 x ULN OR creatinine clearance >= 50 mL/min on the basis of the Cockcroft-Gault glomerular filtration rate estimation (obtained within 11 days prior to first study treatment)
• Glycosylated hemoglobin (HbA1c) =< 7.9 %
• BMI >= 23 kg/m^2
• Patients must agree to consent to the companion genomic profiling study MSK IRB 12-245
• Patients must agree to consent for their tumor samples to be used for generation of cellular research tools such as organoids
• Willingness to travel to the CTSC at WCMC weekly
• Patient and/or legally authorized representative must have the ability to read, write, speak and understand English; note: If patient does not have the capability to read or write in English, the patient's preferred language should be English and the legally authorized representative (LAR) will be responsible for completing all study forms on the patient's behalf

Exclusion Criteria

• History of diabetes and on active diabetes treatment with pharmacotherapy (oral hypoglycemics or insulin)
• History of gout
• History of myocardial infarction or unstable angina within 6 months prior to first study treatment
• Active infection requiring antibiotics (with the exception of uncomplicated urinary tract infection)
• New York Heart Association class II or greater congestive heart failure
• Patients with a corrected QT (QTc) interval of > 450 milliseconds (msec) on screening electrocardiogram (ECG) for men or > 470 msec for women
• History of malabsorption syndrome or other condition that would interfere with enteral absorption
• Inability or unwillingness to swallow
• Clinically significant history of liver disease, including cirrhosis and current alcohol abuse
• Known active hepatitis infection
• Known human immunodeficiency virus (HIV) infection
• Need for current chronic corticosteroid therapy (>= 10 mg of prednisone per day or an equivalent dose of other anti-inflammatory corticosteroids)
• Pregnancy, lactation, or breastfeeding
• Patients of childbearing potential must have a negative pregnancy test within 11 days prior to treatment start to be eligible
• Current severe, uncontrolled systemic disease (e.g., clinically significant cardiovascular, pulmonary, or metabolic disease)
• Major surgical procedure or significant traumatic injury within 28 days prior to day 1 or anticipation of the need for major surgery during the course of study treatment
• Known untreated or active central nervous system (CNS) metastases (progressing or requiring anticonvulsants or corticosteroids for symptomatic control); patients with a history of treated CNS metastases are eligible, provided that they meet all of the following criteria: * Presence of measurable disease outside the CNS * No radiographic evidence of worsening upon the completion of CNS-directed therapy and no evidence of interim progression between the completion of CNS-directed therapy and the screening radiographic study * No history of intracranial hemorrhage or spinal cord hemorrhage * No ongoing requirement for dexamethasone as therapy for CNS disease (anticonvulsants at a stable dose are allowed) * Absence of leptomeningeal disease
• Inability to comply with study and follow-up procedures
• Any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that, in the investigator’s opinion, gives reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or render the patient at high risk from treatment complications
• History of nephrolithiasis or nephrolithiasis including that incidentally discovered during computed tomography (CT) screening
• Known selenium deficiency
• Diagnosis of seizure disorder
• Participation in a diet (Atkins, Weight Watchers, Best Life, Nutrisystem, South Beach, Jenny Craig, Paleo Diet, Zone etc) or weight loss plan within 28 days prior to day 1 of treatment that the investigator and/or nutritionist believes will confound results
• Severe constipation or condition where exacerbation of constipation is not advisable (e.g. small bowel obstruction history)
• Planned vacation or dental work during the study phase that the investigator and/or nutritionist believes will impede the study plan
• Vegetarian or vegan eating habits that cannot be accommodated by the nutrition team
• History of muscle cramps or restless legs
• Untreated or poorly controlled gastro-esophageal reflux disease
• An allergy or intolerance to egg, gluten or milk protein that cannot be accommodated by the nutrition team