Evaluation of Human Immune Responses to Vaccination in Patients with Lymphoma

Inclusion Criteria

• Subjects 18 years of age or above with a diagnosis of lymphoma falling into the following categories: * B-cell non-Hodgkin lymphoma (B-NHL) who have received 1 cycle of chemotherapy * B-NHL in complete remission and within 12 months after completion of chemotherapy * B-NHL in complete remission for over 12 months * Aggressive Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma (PTCL) who have received 1 cycle of chemotherapy * B-NHL on 2+ lines of therapy * Untreated NHL/chronic lymphocytic leukemia (CLL)
• Subject capable of providing written or electronic informed consent prior to initiation of any study procedures; subjects able to understand and comply with planned study procedures and be available for all study visits
• Hemoglobin: 7.0-16.1 gm/dL
• Platelet count: 10-600/uL
• COHORT 1: Subjects who have not received the seasonal influenza vaccine in the current flu season and are not suspected to have had an influenza infection in the current flu season
• COHORT 3: Subjects must have previously received at least 1 dose of SARS-CoV2 vaccine. Patients who have not receive a prior SARS-CoV2 vaccine will be eligible to enroll in cohort 2

Exclusion Criteria

• Known infection with human immunodeficiency virus (HIV); this information will be obtained verbally from the patient
• Have any medical disease or condition that, in the opinion of the site principal investigator is a contraindication to study participation; this includes any chronic medical condition, defined as persisting 3 months (defined as 90 days) or longer, that would place the subject at an unacceptable risk of injury, render the subject unable to meet the requirements of the protocol, or may interfere with the evaluation of responses or the subject’s successful completion of this study
• Have an acute illness, as determined by the site principal investigator within 72 hours prior to study vaccination; an acute illness which is nearly resolved with only minor residual symptoms remaining is allowable if, in the opinion of the site principal investigator, the residual symptoms will not interfere with the ability to assess safety parameters as required by the protocol and was not due to an influenza infection
• Subjects who have a contraindication for influenza or SARS-CoV-2 vaccination
• Subjects who have already received the current influenza or SARS-CoV-2 vaccine
• Subjects taking long-term systemic steroids defined as greater than 3 months in the past 12 months
• Subjects enrolled in hospice or whose life expectancy is less than 6 months