Home-Based Exercise Program in Studying Impact on Prognostic Biomarkers in Participants with Prostate Cancer

PRIMARY OBJECTIVE:

I. To demonstrate the impact of a home based exercise program versus wait-list control to modulate circulating prognostic biomarkers PSA, prostate-specific membrane antigen (PSMA), early prostate cancer antigen (EPCA), urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) in men with prostate cancer.

SECONDARY OBJECTIVE:

I. To demonstrate the capability of a home based exercise program versus wait-list control in improving physical function and body composition in men with prostate cancer.

OTHER OBJECTIVES:

I. To determine if circulating biomarkers are associated with physical function and body composition in men with prostate cancer.

II. To determine the impact of a home based exercise program versus wait-list control to modulate a novel salivary biomarker for fatigue in men with prostate cancer.

III. To determine changes in the gut microbiome in relation to tumor progression markers.

IV. To demonstrate the feasibility of conducting a home based exercise investigation.

OUTLINE: Participants are randomized into 1 of 2 groups.

GROUP I (HOME-BASED EXERCISE PROGRAM): Participants participate in a home-based exercise program consisting of light-to-moderate walking over 30 minutes for 5 days a week for 24 weeks and body-weight exercises comprising 3 sets of 15 repetitions of bodyweight squats, incline push-ups, and hip thrusts or lower intensity exercises such as sit-to-stand, wall push up, and pelvic tilt, 3 days a week for 24 weeks.

GROUP II (WAITLIST-CONTROL): Participants maintain normal activity and visit the Cancer Therapy and Research Center (CTRC) fitness center for research appointments.