This trial studies how well endoesophageal brachytherapy using a 6-channel balloon repositioning, multichannel applicator works in treating in participants with esophageal carcinoma. A 6-channel balloon repositioning, multichannel applicator may work by making the dose more evenly distributed and reducing "hot spots" of radiation (doses above the prescription dose) in the esophageal wall during radiation therapy.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT03335813.
PRIMARY OBJECTIVES:
I. To determine dose distribution and conformality of a 6 channel balloon repositioning applicator.
SECONDARY OBJECTIVES:
I. To collect data in order to show how the 6-tube endoesophageal brachytherapy technique will be an improvement (more conformed dose distribution) over our previously designed 3-tube endoesophageal brachytherapy technique in patients who are candidates for esophageal brachytherapy.
II. To evaluate acute toxicity of novel endoesophageal brachytherapy applicator.
OUTLINE:
Participants undergo endoesophageal brachytherapy over 10-15 minutes weekly for 3-6 weeks using a 6-channel balloon repositioning, multichannel applicator.
After completion of study treatment, participants are followed up for 6 months.
Trial PhaseNo phase specified
Trial Typetreatment
Lead OrganizationCase Comprehensive Cancer Center
Principal InvestigatorJohn Frank Greskovich
