CD19.CAR T Cells in Treating Participants with CD19 Positive Malignancies after Stem Cell Transplant

Inclusion Criteria

• PROCUREMENT CRITERIA
• Group A: CD19+ B-acute lymphoblastic leukemia (ALL) undergoing allogeneic HSCT or
• Group B: CD19+ B cell chronic lymphocytic leukemia (CLL) or non-Hodgkin lymphoma (NHL) undergoing allogeneic HSCT
• Life expectancy of ≥ 12 weeks
• Patient has an appropriate donor identified for hematopoietic stem cell transplantation
• TREATMENT INCLUSION
• Any patient regardless of sex or age with CD19+ B-ALL undergoing allogeneic HSCT (Group A) OR any patient regardless of sex or age with CD19+ B-CLL or NHL undergoing allogeneic HSCT (Group B)
• Residual disease at the time of transplant (bulky or minimal) or post transplant relapse as evidenced by polymerase chain reaction (PCR) positivity, specific cytogenetic abnormalities, an abnormal population on flow cytometry or increased blasts on bone marrow biopsy or in the peripheral blood; minimal residual disease (MRD) will be defined as detection in blood or marrow of any of the following: * Any leukemia specific marker (such as t(9:22) or t(4:11)) documented in the patient’s leukemia cells pre transplant on a post transplant evaluation * An immune globulin rearrangement known to be a disease marker for this patient post transplant * A leukemia specific phenotype post transplant at a level of ≥ 0.01% * Mixed donor chimerism (any level)
• Life expectancy ≥ 6 weeks
• Karnofsky/Lansky score ≥ 50%
• Bilirubin ≤ 2 times the upper limit of normal
• Aspartate aminotransferase (AST) ≤ 3 times the upper limit of normal
• Estimated glomerular filtration rate (GFR) > 50 mL/min
• Hemoglobin (Hgb) > 8.0 (can be transfused)
• Pulse oximetry of > 90% on room air
• Sexually active patients must be willing to utilize one of the more effective birth control methods during the study and for 6 months after the study is concluded; the male partner should use a condom
• Available allogeneic activated peripheral blood T cell products with ≥ 15% expression of CD19.CAR-CD28zeta determined by flow cytometry (cell dose is based on total cell numbers and not individual anti-leukemic cell numbers)
• No other investigational antitumor therapy for one month prior to entry in this study
• Patients or legal guardians must sign an informed consent indicating that they are aware this is a research study and have been told of its possible benefits and toxic side effects; patients or their guardians will be given a copy of the consent form

Exclusion Criteria

• TREATMENT EXCLUSION
• Severe intercurrent infection
• Evidence of graft versus host disease (GVHD) > grade II
• Pregnant or lactating
• History of hypersensitivity reactions to murine protein-containing products
• Currently taking corticosteroids (> 0.5 mg/kg/day prednisone or equivalent) for therapy of GVHD