Cyclophosphamide, Fludarabine Phosphate, and Total Body Radiation, before Donor Stem Cell Transplant in Treating Participants with Blood Disorders and Blood Cancers

Inclusion Criteria

• The patient must be approved for transplant by the treating transplant physician. This includes completion of their pre-transplant workup, as directed by standard Dartmouth Hitchcock Medical Center (DHMC) standard operating procedures (SOPs) (DHMC SOP – Pre-transplant Evaluation of Allogeneic Recipient).
• The patient must have a disease (listed below) with treatment-responsiveness that the treating transplant physician believes will benefit from an allogeneic stem cell transplant. The diseases include: * Acute leukemia – Acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) * Chronic leukemia – Chronic myelogenous leukemia (CML), chronic lymphocytic leukemia (CLL) * Myelodysplasia * Myeloproliferative disorder * Myelofibrosis * Lymphoma – Non-Hodgkin lymphoma (NHL) or Hodgkin’s disease * Plasma cell disorder, including myeloma, Waldenstrom’s macroglobulinemia.
• The patient must have an identified RELATED haploidentical (haplo)-identical donor.
• No human immunodeficiency virus (HIV) infection or active hepatitis B or C.
• Eastern Cooperative Oncology Group (ECOG) performance status: 0-2.
• Carbon monoxide diffusing capacity (DLCO) 40% predicted.
• Left ventricular ejection fraction >= 40%.
• Serum bilirubin < 2 x upper limit of normal.
• Transaminases < 3 x normal at the time of transplant.
• No active or uncontrollable infection.
• In female, a negative pregnancy test if experiencing menstrual periods.
• No major organ dysfunction precluding transplantation.
• No evidence of an active malignancy that would limit the patient’s survival to less than 2 years. (If there is any question, the principal investigator [PI] can make a decision).
• DONOR: Human leukocyte antigen (HLA) haplo-identical matched related.
• DONOR: The donor must be healthy and must be willing to serve as a donor, based on standard National Marrow Donor Program (NMDP) guidelines and DHMC SOP – Donor Evaluation.
• DONOR: The donor must have no significant co-morbidities that would put the donor at marked increased risk.
• DONOR: There is no age restriction for the donor.
• DONOR: Informed consent must be signed by donor.

Exclusion Criteria

• Psychiatric disorder or a mental deficiency of the patient that is sufficiently severe to make compliance with the treatment unlikely, and making informed consent impossible.
• Major anticipated illness or organ failure incompatible with survival from bone marrow transplantation (BMT).
• History of refractory systemic infection.
• DONOR: The NMDP guidelines for exclusion criteria will be used.
• DONOR: Pregnant or lactating donor.
• DONOR: HIV or active hepatitis (Hep) B or C in the donor.
• DONOR: Donor unfit to receive granulocyte colony-stimulating factor (G-CSF) and undergo apheresis.
• DONOR: A donor with a psychiatric disorder or mental deficiency that makes compliance with the procedure unlikely and informed consent impossible.