Light Dosimetry for Photodynamic Therapy with Porfimer Sodium in Treating Patients with Malignant Mesothelioma, Non-small Cell Lung Cancer, or Other Malignancies with Pleural Disease Undergoing Surgery

Inclusion Criteria

• Histologically confirmed malignant mesothelioma or non-small cell lung cancer (NSCLC), or other malignancies with pleural disease without distant disease.
• Male or female patients at least 18 years old.
• Subjects must have an Eastern Cooperative Oncology Group (ECOG) scale of 0-2.
• Subjects of child-bearing potential must agree to use adequate contraceptive methods (e.g., hormonal or barrier method of birth control; abstinence) prior to study entry and for 6 months after surgery. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.
• The subject must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent prior to receiving any study related procedure.

Exclusion Criteria

• Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
• Patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events.
• Patients with porphyria, or with known hypersensitivity to porphyrins or porphyrin-like compounds.
• White blood cell (WBC) < 4,000.
• Platelet count < 100,000.
• Total serum bilirubin > 2 mg/dL.
• Serum creatinine > 2 mg/dL.
• Alkaline phosphatase > 3 times the upper normal limit.
• Serum glutamic oxaloacetic transaminase (SGOT) or serum glutamate pyruvate transaminase (SGPT) > 3 times the upper normal limit.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Pregnant or nursing female subjects.
• Unwilling or unable to follow protocol requirements.
• Any condition which in the investigator’s opinion deems the subject an unsuitable candidate to receive porfimer sodium.
• Received an investigational agent within 30 days prior to enrollment.
• The following special populations are excluded from this study: * Cognitively impaired adults/adults with impaired decision-making capacity * Individuals who are not yet adults (infants, children, teenagers) * Prisoners * Pregnant women.