rTMS in Promoting Smoking Cessation and Preventing Relapse in Current Smokers

Inclusion Criteria

• Participants will be healthy right-handed adults
• Age 18 years old or over
• Negative urine drug screen at the baseline assessment
• Ability to read at the 8th grade level
• Passes the Transcranial Magnetic Stimulation Adult Safety and Screening Questionnaire (TASS)
• Participants must smoke between 5 and 25 cigarettes per day with the intent to quit smoking in the next 30 days
• Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure
• Study 1: Participants will be right-handed lung cancer or head and neck cancer patients
• Study 1: Age 18 years or older
• Study 1: Negative urine drug screen at the baseline assessment
• Study 1: Ability to read at the 8th grade level
• Study 1: Passes the Transcranial Magnetic Stimulation Adult Safety and Screening Questionnaire (TASS)
• Study 1: Participants must smoke at least 4 cigarettes per day and intend to quit smoking in the next 60 days
• Study 1: Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure
• Study 1: Has been diagnosed with primary non-small and small cell LC or with primary non-skin squamous cell HNC (self-reported)
• Study 2: Participants will be healthy right-handed adults
• Study 2: Age 18 years old or over
• Study 2: Negative urine drug screen at the baseline assessment
• Study 2: Ability to read at the 8th grade level
• Study 2: Passes the Transcranial Magnetic Stimulation Adult Safety and Screening Questionnaire (TASS)
• Study 2: Participants must smoke between 5 and 25 cigarettes per day with the intent to quit smoking in the next 30 days
• Study 2: Meet the criteria for heavy alcohol use: > 7 drinks per week for women, > 15 drinks per week for men OR binge drinking >= 5 days in the past month. Binge drinking is defined as >= 4 drinks for women and >= 5 drinks for men, consumed within 2 hours of each other
• Study 2: Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure.

Exclusion Criteria

• Has a personal history of epilepsy
• Has a history of anticonvulsant medication use
• Has a personal history of head injury
• Has a history of aneurysm, stroke, or previous cranial neurosurgery or abnormal findings on the magnetic resonance imaging (MRI) (e.g., tumor, aneurism, etc.)
• Has a diagnosis of major depressive disorder, bipolar disorder or a schizophrenia-spectrum disorder, or tinnitus
• Has any metal implants or neuro-stimulators in the head, neck, or cochlea that prevent an MRI being performed
• Has a pacemaker
• Personal history of migraine headaches
• Currently taking medications that lower seizure threshold (e.g., such as tricyclic antidepressants or bupropion)
• Currently using medications for tobacco cessation (e.g., nicotine replacement, bupropion, varenicline, etc…)
• Is pregnant or planning to become pregnant in the next 24 weeks
• Current regular use of forms of tobacco other than cigarettes
• Participants who score above 48.3 on the Claustrophobia Questionnaire at the baseline assessment will be excluded because they are likely to be unable to undergo a magnetic resonance imaging (MRI) without distress
• Unwilling or unable to follow protocol requirements
• Any condition which in the investigator’s opinion deems the participant an unsuitable candidate to participate in the study
• Study 1: Has a personal history of brain metastases
• Study 1: Unable to use nicotine patches
• Study 1: Has a personal history of epilepsy
• Study 1: Has a history of anticonvulsant medication use
• Study 1: Has a personal history of serious head injury
• Study 1: Has a history of aneurysm, stroke, or previous cranial neurosurgery or abnormal findings on the MRI (e.g., tumor, aneurism, etc.)
• Study 1: Has uncontrolled major depressive disorder, bipolar disorder or a schizophrenia-spectrum disorder, or tinnitus
• Study 1: Has any metal implants or neuro-stimulators in the head, neck, or cochlea that prevent an MRI being performed
• Study 1: Has a pacemaker
• Study 1: Personal history of migraine headaches
• Study 1: Currently taking medications that lower seizure threshold (e.g., such as tricyclic antidepressants or bupropion)
• Study 1: Currently using bupropion or varenicline for smoking cessation
• Study 1: Is pregnant or planning to become pregnant in the next 24 weeks
• Study 1: Current regular use of forms of tobacco other than cigarettes including e-cigarettes
• Study 1: Participants who score above 48.3 on the Claustrophobia Questionnaire at the baseline assessment will be excluded because they are likely to be unable to undergo a magnetic resonance imaging (MRI) without distress
• Study 1: Individuals who score > 15, indicative of moderate-severe alcohol use disorder, on the Alcohol Use Disorders Identification Test (AUDIT)
• Study 1: Unwilling or unable to follow protocol requirements
• Study 1: Any condition which in the Investigator’s opinion deems the participant an unsuitable candidate to participate in the study
• Study 2: Has a personal history of epilepsy
• Study 2: Has a history of anticonvulsant medication use
• Study 2: Has a personal history of head injury
• Study 2: Has a history of aneurysm, stroke, or previous cranial neurosurgery or abnormal findings on the MRI (e.g., tumor, aneurism, etc.)
• Study 2: Has a diagnosis of major depressive disorder, bipolar disorder or a schizophrenia-spectrum disorder, or tinnitus
• Study 2: Has any metal implants or neuro-stimulators in the head, neck, or cochlea that prevent a MRI being performed
• Study 2: Has a pacemaker
• Study 2: Personal history of migraine headaches
• Study 2: Currently taking medications that lower seizure threshold (e.g., such as tricyclic antidepressants or bupropion)
• Study 2: Currently using medications for tobacco cessation (e.g., nicotine replacement, bupropion, varenicline, etc.)
• Study 2: Is pregnant or planning to become pregnant in the next 24 weeks
• Study 2: Current regular use of forms of tobacco other than cigarettes
• Study 2: Participants who score above 48.3 on the Claustrophobia Questionnaire at the baseline assessment will be excluded because they are likely to be unable to undergo a magnetic resonance imaging (MRI) without distress
• Study 2: Have ever met Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-V) criteria for alcohol withdrawal
• Study 2: Unwilling or unable to follow protocol requirements
• Study 2: Any condition which in the Investigator’s opinion deems the participant an unsuitable candidate to participate in the study