HERV-E TCR Transduced CD8+/CD34+ T-cells in Treating Patients with Metastatic Clear Cell Renal Cell Cancer

Inclusion Criteria

• Patients must have histologically confirmed renal cell carcinoma (RCC) with clear-cell component by the Laboratory of Pathology of the National Institutes of Health (NIH) and/or outside Pathology Department prior to entering this study
• Patients must be HLA-A 11:01 positive (confirmed by HLA typing at the NIH Department of Transfusion Medicine [DTM])
• Patients must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 and have disease progression during or after the last treatment regimen and within 6 months before study enrollment
• Patients must have received at least one antiangiogenic drug and an immune-checkpoint inhibitor (i.e. nivolumab) unless the patient has contraindications to receiving these medications, the agents are not available to the patient, or the patient declines to receive these drugs due to personal preference
• Patients must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, the duration of study participation and 180 days (female patients) or 90 days (male patients) after the end of the treatment if sexually active and able to bear or beget children. In addition, male patients must refrain from sperm donation for 90 days after the final dose of investigational product. Female patients must refrain from egg cell donation for 180 days after the final dose of investigational product
• Patients must be between the ages of 18 and 75 years
• Patient must have an anticipated life expectancy of at least 3 months
• Patients must have a performance status of 0 or 1 Eastern Cooperative Oncology Group (ECOG) performance status (PS) scale
• Patients must have a caregiver willing to stay with them during the first month of treatment (30 days +/- 7 days)
• Patients receiving treatment with bisphosphonates or denosumab are eligible for enrollment if on a stable dose for >= 4 weeks
• Serology: * Seronegative for human immunodeficiency virus (HIV) antibody. (The experimental treatment being evaluated in this protocol depends on an intact immune system. Patients who are HIV seropositive can have decreased immune-competence and thus be less responsive to the experimental treatment and more susceptible to its toxicities) * Seronegative for hepatitis B antigen, and seronegative for hepatitis C antibody. If hepatitis C antibody test is positive, then patient must be tested for the presence of antigen by reverse transcription-polymerase chain reaction (RT-PCR) and be hepatitis C virus (HCV) ribonucleic acid (RNA) negative
• Absolute neutrophil count >= 500/uL
• White blood cells >= 1500/uL
• Platelet count >= 75,000/uL (without transfusional support)
• Serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN)
• Total bilirubin =< 1.5 mg/dl except for patients with Gilbert’s syndrome who must have a total bilirubin =< 3 mg/dl
• Creatinine clearance ≥ 50 ml/min/1.73 m^2 by the method of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) or ≥ 50 ml/min by the method of 24 hour (h) Clearance of Creatinine Calculation
• International normalized ratio (INR) < 1.5
• Estimated left ventricular ejection fraction by echocardiography >= 45%
• Predicted diffusion capacity of the lung for carbon monoxide (DLCO)/alveolar volume adjusted by pulmonary function test (PFT) >= 45%

Exclusion Criteria

• Patients that require immediate therapy due to tumor mass effects or spinal cord compression
• Patients must not have had standard of care anti-VEGFR therapy (mean half-life around 30 hours), mTOR inhibitors (mean half-life around 30 hours) at least for the last 7 days prior to T-cell infusion, and radiotherapy, or major surgery within the last 2 weeks prior to T-cell infusion. For PD-1/PD-L1 inhibitors or CTLA-4 inhibitors, a 4-week period must have elapsed before T-cell infusion. For recent experimental therapies a 28-day period must have elapsed before infusing expanded T-cells
• Patients with active central nervous system (CNS) involvement by malignancy either by imaging or cerebrospinal fluid involvement or biopsy-proven (due to poor prognosis and potential for neurological dysfunction that would confound evaluation of neurological and other adverse events) except for: * Patients with 3 or fewer brain metastases of < 1 cm treated with either stereotactic or gamma knife radiotherapy and remained stable on MRI for 2 weeks are eligible * Patients with surgically resected brain metastases and no evidence of active disease in the CNS at the time of screening evaluation are eligible
• Patients with hypercalcemia (> 10 mg/dL) of malignancy
• Any prior grade >= 3 immune-related adverse event (irAE) while receiving immunotherapy, including anti-CTLA4 treatment that requires long-term immunosuppressive therapy. Note: active or history of vitiligo or hypothyroidism will not be a basis for exclusion
• Patients with second malignancies in addition to their clear cell RCC are not eligible if the second malignancy has required treatment within the past 4 years or is not in complete remission. There are exceptions to this criterion: successfully treated non-metastatic basal cell, squamous cell skin carcinoma, in situ non-invasive cervical cancer and in situ non-invasive breast cancer
• Women of child-bearing potential who are pregnant or breastfeeding because of the potentially dangerous effects of the preparative chemotherapy on the fetus or infant
• Active uncontrolled systemic infections (defined as infections causing fevers and/or infections requiring intravenous antibiotics when intravenous antibiotics have been administered for less than 72 hours)
• Active coagulation disorders or other major uncontrolled medical illnesses of the respiratory, endocrine, renal, gastrointestinal, genitourinary or immune system, active obstructive or restrictive pulmonary disease
• Patients who have recent history of cerebrovascular accident, transient ischemic attack should be cleared by the neurology consult service before enrolling this study.
• Patients who have recent history of coronary artery disease or cardiac arrhythmia should be cleared by the cardiology consult service before enrolling this study
• Any form of primary immunodeficiency (such as severe combined immunodeficiency disease)
• Patients with autoimmune diseases such as Crohn’s disease, ulcerative colitis, rheumatoid arthritis, autoimmune hepatitis or pancreatitis, and systemic lupus erythematosus that requires treatment with chronic immunosuppressive therapy
• Systemic corticosteroid steroid therapy of any dose is not allowed within 2 days prior to enrollment. The following are exceptions to this criterion: * Intranasal, inhaled, and topical steroids * Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or equivalent * Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
• History of severe immediate hypersensitivity reaction to any of the agents used in this study
• Unable to understand the investigational nature of the study or give informed consent and does not have a legally authorized representative or surrogate that can provide informed consent
• Any condition that, in the opinion of the investigator, would interfere with evaluation of the investigational product or interpretation of subject safety or study results