Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients with Soft Tissue Sarcoma, Bone Sarcoma, or Colorectal Cancer Metastatic to the Lungs

Inclusion Criteria

• Tumors metastatic to the lungs that are the focus of this protocol specifically: * Soft tissue sarcoma * Osteosarcoma * Colorectal carcinoma
• Age >= 18 years of age
• Have an Eastern Cooperative Oncology Group (ECOG) performance status of =< 2
• Hemoglobin > 8.0 g/L
• Granulocytes > 1,500 uL
• Platelets >= 100,000 uL
• Creatinine clearance >= 30 mL/min
• Clinically diagnosed resectable lung metastases (while pre-registration histologic or cytologic confirmation is desirable, this may not be required in clinical scenarios where a biopsy may not change the need to resect suspicious lung nodules or the biopsy itself poses a risk for tumor seeding. In such cases, the diagnosis will be supported by rapid pathologic evaluations intraoperatively before proceeding with Suffusion). Given the emergence of other acceptable options to destroy lung metastases such as stereotactic body radiation therapy (SBRT) or microwave ablation, a hybrid approach to eliminate all sites of disease will be permitted; however, supplemental approaches should be delayed, if possible, until after the 30 day post-suffusion endpoint.
• Have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria present
• Forced expiratory volume in 1 second (FEV1) >= 50% predicted
• Diffusion capacity of the lung for carbon monoxide (DLCO) >= 50% predicted
• Vital capacity (VC) >= 50% predicted
• Ambulatory and resting oxygen (O2) saturation > 88%
• Six minute walk >= 50 % of the expected distance
• Surgeon affirmation that suffusion is technically feasible
• Borg Dyspnea scale (modified) < 5
• Control of the primary tumor as determined by clinical assessment per standard of care; may include stable tumor status of primary tumor and other metastases, in the clinical judgement of the principal investigator (PI)/physician
• Participants of child-bearing potential must agree to use adequate contraceptive methods (e.g., hormonal or barrier method of birth control; abstinence) prior to study entry. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
• Participant or legal representative must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure

Exclusion Criteria

• Participants who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier
• Participants with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events
• Allergy, intolerance, or other serious reaction to cisplatin or any other alternate chemotherapy drug that may be used in the procedure
• Pregnant or nursing female participants
• Unwilling or unable to follow protocol requirements
• Pulmonary metastases unable to be completely resected or ablated based on pre-registration review of imaging by a thoracic surgeon or proceduralist
• Any additional condition which in the investigator’s opinion deems the participant an unsuitable candidate to receive study drug or the suffusion technique
• Received an investigational agent within 30 days prior to enrollment
• The following special populations are excluded from this study: * Cognitively impaired adults/adults with impaired decision-making capacity * Individuals who are not yet adults (infants, children, teenagers) * Pregnant women * Prisoners