This study will examine the biologic processes through which exercise may prevent disease
recurrence in patients who have completed treatment for colorectal cancer.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT03975491.
Locations matching your search criteria
United States
Louisiana
Baton Rouge
Pennington Biomedical Research CenterStatus: Active
Contact: Justin Brown
This randomized trial will examine the biological effects of 12-weeks of
moderate-intensity aerobic exercise versus wait-list control in 60 subjects who have
completed standard medical therapy for colorectal cancer. The primary objective is to
determine if aerobic exercise can reduce systemic inflammation, quantified using plasma
concentrations of high-sensitivity C-reactive protein and interleukin-6. The secondary
objectives are to determine if exercise can reduce: 1) insulin resistance quantified
using an oral glucose tolerance test, and; 2) circulating tumor cells quantified using a
microfluidic antibody-mediated capture platform. The exploratory objective is to
determine if exercise can improve mitochondrial respiration rates and fatty acid
oxidation in peripheral blood mononuclear cells and tumor fraction.
Trial PhaseNo phase specified
Trial Typetreatment
Lead OrganizationPennington Biomedical Research Center
