This trial studies the metabolism of kidney or urothelial cancer in patients undergoing surgical removal (resection) and/or biopsy. Metabolism is the term used to describe how cells take up different nutrients and convert them to energy and materials needed for cell growth. In cancer, metabolism is hijacked to support the needs of cancer cells. Cancer cells can use multiple nutrients in the blood to fuel their growth, but it is not yet known what materials cancer cells make with those nutrients in patients. This study may help researchers understand how kidney cancers change their metabolism to adapt, grow, and survive in patients. The researchers may use the knowledge from this study to support development of therapies that target metabolic adaptations of cancer cells, and to develop new, non-invasive imaging techniques that can be used to monitor tumor growth.
Additional locations may be listed on ClinicalTrials.gov for NCT04623502.
Locations matching your search criteria
United States
Texas
Dallas
UT Southwestern/Simmons Cancer Center-DallasStatus: Active
Contact: Vitaly Margulis
Phone: 214-648-0567
EXPLORATORY OBJECTIVES:
I. Compare metabolic phenotypes of different kidney cancer subtypes in primary renal tumors.
II. Determine metabolic features of kidney cancer that distinguish radiologically distinct regions of primary renal tumors
III. Compare metabolic phenotypes of primary kidney cancer tumors and metastases.
IV. Identify metabolic changes in primary or metastatic kidney cancer tumors that occur after targeted therapy.
OUTLINE:
During standard of care surgery and/or biopsy, patients may receive one of the nutrient tracers; uniformly-labeled [U-13C]glucose, uniformly-labeled [13C]lactate, carbon C 13 acetate, uniformly-labeled [13C]glutamine, or uniformly-labeled [13C]fructose intravenously (IV) over 3 hours and undergo collection of blood samples every 30 minutes during the 13C nutrient infusion.
Trial PhaseNo phase specified
Trial TypeNot provided by clinicaltrials.gov
Lead OrganizationUT Southwestern/Simmons Cancer Center-Dallas
Principal InvestigatorVitaly Margulis