This phase II trial studies how well 18F-DCFPyL PET/CT scan works in detecting a protein called PSMA in patients with HER2-negative, androgen receptor positive breast cancer. PET takes pictures of the inside the body using a special substance or “tracer” that is injected through a needle in the arm. 18F-DCFPyL is the tracer that is used in this research. PET images are made when the scanner detects the levels of the tracer throughout the entire body. CT scans take 3-dimensional pictures of inside the body using x-rays. Currently, PET and CT images are collected at the same time because the CT scan provides images of the body’s anatomy and the PET scan shows where in the body the tracer is more concentrated. This trial may help researchers develop novel ways to detect and treat breast cancer.
Additional locations may be listed on ClinicalTrials.gov for NCT04573231.
Locations matching your search criteria
United States
Wisconsin
Madison
University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterStatus: Active
Contact: Steve Yoon-Ho Cho
University of Wisconsin Carbone Cancer Center - University HospitalStatus: Active
Contact: Steve Yoon-Ho Cho
Phone: 608-263-5048
PRIMARY OBJECTIVE:
I. To evaluate the expression of prostate-specific membrane antigen (PSMA) via fluorine F 18 DCFPyL (18F-DCFPyL) PSMA-based positron emission tomography (PET)/computed tomography (CT) in patients with metastatic HER2-negative, AR-positive breast cancer.
SECONDARY OBJECTIVES:
I. PSMA PET will be compared with the expression of PSMA in circulating tumor cell (CTC)s and diagnostic metastatic tissue from patients with HER2-negative, AR-positive metastatic breast cancer.
II. PSMA expression will be correlated with clinical benefit (objective response and progression-free survival) to bicalutamide and ribociclib for patients enrolled in UW16044.
OUTLINE:
Patients receive fluorine F 18 DCFPyL intravenously (IV). Patients then undergo PET/CT over 30 minutes.
After completion of trial, patients are followed up at 1-3 days.
Lead OrganizationUniversity of Wisconsin Carbone Cancer Center - University Hospital
Principal InvestigatorSteve Yoon-Ho Cho