An Investigational Scan (PET-MRI) for the Characterization of Clear Cell Renal Cell Carcinoma

Inclusion Criteria

• Has voluntarily provided signed informed consent to participate and Health Insurance Portability and Accountability Act (HIPAA) authorization for release of personal health information
• Must have clinically-suspected clear cell renal cell carcinoma (ccRCC) based on prior imaging with tumor size >= 7 cm
• Planned to have standard of care nephrectomy with a schedule that can accommodate a magnetic resonance (MR)-FDG-PET scan within 4 weeks prior to surgery
• Must be able to meet size restrictions for the PET-MR scanner
• Must be able to understand and comply with study procedures for the entire length of the study
• Must receive their nephrectomy at University of North Carolina (UNC) Chapel Hill hospitals
• If patient has a history of prior malignancy, including melanoma, patient must be cancer-free for three or more years. Non-melanoma skin cancers will be included even if not cancer-free for three years
• Women of childbearing potential must have a negative urine pregnancy test performed the day of and prior to PET/MRI imaging
• Willing to undergo finger-stick blood glucose tests

Exclusion Criteria

• Inability to tolerate MRI (e.g., inability to lie flat for > 1 hour or needs lorazepam to tolerate MRI)
• Documented hypersensitivity to gadolinium contrast agent
• Presence of pacemaker, intracranial aneurysm clip, bladder stimulator, cochlear implant or metal near eyes or near pelvis that would create excessive imaging artifact
• Failure of two blood glucose tests (blood glucose level greater than 200 mg/dL) on day of first scheduled scan visit and on rescheduled day
• Patient receiving neoadjuvant therapy for RCC
• Unwilling or unable to complete informed consent
• Evidence of distant disease on physical exam or initial imaging
• Incarcerated patients or patients with medical power of attorney at time of enrollment