Community-Based Health Coach to Improve Access to Germline Genetic Testing among African American Men with Prostate Cancer, The Navigate Study

PRIMARY OBJECTIVES:

I. To assess uptake of genetic testing using tailored education strategies and culturally relevant cancer resources delivered by a community-based health coach. (PREVIOUS PILOT STUDY)

II. To assess barriers to the intervention. (CURRENT STUDY - PART 1)

III. To evaluate consent rate of germline testing among patient participants receiving the intervention. (CURRENT STUDY - PART 2)

SECONDARY OBJECTIVES:

I. To assess decisional conflict among African American men receiving tailored education strategies and culturally relevant cancer resources on genetic testing delivered by a community-based health coach. (PREVIOUS PILOT STUDY)

II. To assess facilitators to the intervention. (CURRENT STUDY - PART 1)

III. To assess acceptability of the intervention. (CURRENT STUDY - PART 1)

IV. To characterize patient and health coach use of ProGene. (CURRENT STUDY - PART 1)

V. To evaluate completion rate of germline testing among patient participants receiving the intervention. (CURRENT STUDY - PART 2)

VI. To evaluate acceptability of the intervention among patient participants. (CURRENT STUDY - PART 2)

VII. To evaluate change in participant knowledge about germline testing among patient participants. (CURRENT STUDY - PART 2)

VIII. To evaluate change in participant attitudes toward germline testing among patient participants. (CURRENT STUDY - PART 2)

IX. To evaluate change in decisional conflict about germline testing among patient participants. (CURRENT STUDY - PART 2)

X. To evaluate reach of the intervention. (CURRENT STUDY - PART 2)

XI. To evaluate barriers and facilitators to the intervention. (CURRENT STUDY - PART 2)

XII. To identify reasons for declining germline testing. (CURRENT STUDY - PART 2)

TERTIARY OBJECTIVE:

I. To assess the germline mutation rate among African American men with prostate cancer. (PREVIOUS PILOT STUDY)

OUTLINE:

PREVIOUS PILOT STUDY (NO LONGER ENROLLING - 04/04/2025): Patients are assigned to 1 of 2 cohorts.

COHORT A: Patients complete a survey about knowledge of, attitudes towards, and awareness of genetic testing and technology preferences and use over 30 minutes at baseline and over 20 minutes at exit or follow up. Patients may also undergo genetic testing and genetic counseling if they receive positive results.

COHORT B: Patients participate in educational session with health coach over 60 minutes. Patients also complete a survey about knowledge of, attitudes towards, and awareness of genetic testing and technology preferences and use over 30 minutes at baseline and over 20 minutes at exit or follow up. Patients may also undergo genetic testing and genetic counseling if they receive positive results.

CURRENT STUDY (AS OF 12/04/2025):

PART 1: Patients attend a session over 15-30 minutes with a health coach that provides tailored education strategies, delivers culturally relevant cancer resources for patient participants, and facilitates patient interactions with the ProGene artificial intelligence (AI) assistant.

PART 2: Patients attend a session over 15-30 minutes with a health coach that provides tailored education strategies, delivers culturally relevant cancer resources for patient participants, and facilitates patient interactions with the ProGene AI assistant. Patients may also undergo genetic testing and genetic counseling if they receive positive results.