This clinical trial examines if using a new imaging technique called perfusion blood volume (PBV) imaging, in combination with dual energy computed tomography (DECT) and/or four-dimensional x-ray computed tomography (4DCT) imaging, can help to detect changes lung functioning before, during, and after treatment with chemotherapy and radiation in patients with stage III or IV non-small cell lung cancer. Performing these scans in combination with routine, standard of care scans, may help research determine if targeting specific areas of the lung (functional lung) versus the whole lung can potentially decrease overall damage to lungs.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT04702607.
PRIMARY OBJECTIVES:
I. To evaluate the reproducibility of PBV DECT imaging and 4DCT derived lung ventilation imaging for evaluating lung function by imaging at multiple time points.
II. To correlate changes in PBV DECT and 4DCT lung function images with radiation dose and with patient reported loss of lung function at 6 months.
SECONDARY OBJECTIVE:
I. To develop a functional lung-dose response that predicts PBV DECT and 4DCT lung function changes that can then be used in a subsequent clinical trial.
OUTLINE:
Patients receive iodine contrast intravenously (IV) and undergo DECT before radiation, during radiation, and after radiation (6-month follow up). Patients also undergo standard of care computed tomography (CT) scan and 4DCT scan before radiation and during radiation.
Trial PhaseNo phase specified
Trial Typediagnostic
Lead OrganizationUniversity of Pennsylvania/Abramson Cancer Center
Principal InvestigatorSteven J. Feigenberg
