Bacterial Decolonization for the Prevention of Radiation Dermatitis in Patients with Breast or Head and Neck Cancer Receiving Radiotherapy

This phase II/III trial studies the effect of decreasing bacteria on the skin (bacterial decolonization) before treatment with radiation in preventing radiation dermatitis in patients with breast or head and neck cancer. Radiation dermatitis is a common rash that can occur from radiation therapy. Previous study showed that people who have bacteria in their nose prior to initiation of radiotherapy have an increased risk of developing radiation dermatitis. Bacterial decolonization may prevent high-grade radiation dermatitis and improve quality of life during radiotherapy in patients with breast or head and neck cancer.

Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT03883828.

Trial PhasePhase II/III

Trial Typeprevention

Lead OrganizationMontefiore Medical Center-Weiler Hospital

Principal InvestigatorBeth Mclellan

• Primary ID2018-9722
• Secondary IDsNCI-2021-02745
• ClinicalTrials.gov IDNCT03883828