This clinical trial investigates whether changes in household and personal behavior aimed at reducing exposure to environmental chemicals in dust (increased house dust removal efforts/cleaning and hand washing) and consumer products (increased use of personal care and beauty products that are free of chemicals including phthalates, parabens, and phenols) results in lower exposure to environmental chemicals including polycyclic aromatic hydrocarbons (PAH) and endocrine disrupting chemicals including phthalates, parabens and phenols. These chemicals may have harmful health effects, as they can interfere with normal functions of the body. A family-based intervention may help reduce exposure to these chemicals.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT04265547.
PRIMARY OBJECTIVES:
I. To examine whether the intervention changes measures of breast tissue components in the daughter measured at two time points (baseline, 6 months).
II. To examine whether the intervention changes measures of breast tissue components in the mother measured at two time points (baseline, 6 months).
III. To examine whether the intervention reduces selected urinary measures of exposures measured at two time points (baseline, 6 months) in mothers and daughters.
OUTLINE: Mother-daughter pairs are randomized to 1 of 2 groups.
GROUP A: Participants complete questionnaires over 20 minutes about the types of personal care and beauty products that they use, as well as their usual cleaning and cooking habits, and undergo collection of urine samples at baseline and 2 weeks. Participants view an educational video over 20 minutes and receive an informational handout at baseline about how to read consumer product labels, cleaning methods, and cooking practices to reduce exposure to toxins. Participants receive a 6 month-supply of soap, lotion, deodorant, lip balm, a mop, cleaning cloths, and an air filter to take home with them.
GROUP B: Participants complete questionnaires over 20 minutes about the types of personal care and beauty products that they use, as well as their usual cleaning and cooking habits, and undergo collection of urine samples at baseline and 2 weeks. Participants view an educational video over 20 minutes and receive an informational handout at baseline about how to read consumer product labels, cleaning methods, and cooking practices to reduce exposure to toxins.
After completion of intervention, participants are followed up at 6 months.
Trial PhaseNo phase specified
Trial Typeprevention
Lead OrganizationNYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
Principal InvestigatorMary Beth Terry
