Esophageal Cancer Risk Registry

Inclusion Criteria

• Patients with any esophageal or gastroesophageal junction malignancy
• Patients referred for diagnostic evaluation of a suspected esophageal or gastroesophageal junction malignancy
• Patients with known Barrett’s metaplasia
• Patients referred for clinical management of symptomatic gastroesophageal reflux disease
• Patients with achalasia
• Patients with hiatal hernia

Exclusion Criteria

• Patients with elevated pre-operative blood work will be excluded from undergoing additional biopsies during their routine upper endoscopy. The coagulating factors are measured as part of the standard of care routine pre-operative blood work
• Subjects with a platelet count less than 150,000, partial thromboplastin time (PTT) of 50 or above, and/or international normalized ratio (INR) of 1.8 or above will be excluded from the additional biopsy tissue collection