Comparison of Surgery to Stereotactic Body Radiation Therapy (SBRT) in Patients With Stage I Non-Small Cell Lung Cancer

Inclusion Criteria

• Clinical stage I NSCLC (T1 or T2a, N0, M0) by computed tomography (CT) scan performed within 90 days of treatment. * Positron emission tomography (PET)/CT is required within 90 days of screening except under circumstances where the clinical picture suggests, or biopsy confirms, a low-grade adenocarcinoma. * Biopsy is strongly encouraged. In the event biopsy is not performed, rationale must be provided for performing empiric treatment. * Patients with hilar or mediastinal lymph nodes =< 1 cm and no abnormal hilar or mediastinal uptake on PET will be considered N0. Pre-treatment mediastinal lymph node sampling by any technique is allowed but not required. Patients with > 1 cm hilar or mediastinal lymph nodes on CT or abnormal PET (including suspicious but nondiagnostic uptake) are eligible only if directed tissue biopsies of all abnormally identified areas are negative for cancer
• First primary NSCLC on the ipsilateral side
• At least 18 years of age
• Clinically eligible for either treatment (surgical resection or SBRT). Because this is a pragmatic study and treatment decisions are at the discretion of the treating physicians and their patients, patients must be eligible for either treatment.
• Eastern Cooperative Oncology Group (ECOG) performance status <= 2
• No home oxygen use
• Forced expiratory volume in 1 second (FEV1) and diffusing capacity of the lung for carbon monoxide (DLCO) >= 40% predicted measured within 2 years of enrollment
• No symptomatic congestive heart failure as documented by New York Heart Association (NYHA) I-II functional classification
• Been deemed operable by a thoracic surgeon, per clinical visit or review of the medical record and as documented by e-mail, tumor board, study meetings, or other acceptable source documentation. In addition to operability, the surgeon must define what anticipated surgical approach and procedure would be undertaken
• Been deemed treatable by a radiation oncologist with 10 or fewer fractions of SBRT, per clinical visit or review of the medical record and as documented by e-mail, tumor board, study meetings, or other acceptable source documentation. In addition to suitability for SBRT, the radiation oncologist must define which dose and fractionation would be undertaken
• Ability to understand and willingness to sign an institutional review board (IRB)-approved written informed consent document.
• Agrees to receive treatment for clinical stage I NSCLC (either surgical resection or SBRT)

Exclusion Criteria

• Prior or concurrent malignancies, unless the natural history of the prior or concurrent malignancy does not have the potential to interfere with the interpretation of the results of the study.
• Clinically diagnosed or biopsy proven low-grade neuroendocrine carcinoma (carcinoid)
• Prior thoracic radiation therapy that would overlap with the lung cancer being treated on study
• Previous chemotherapy, radiotherapy, or surgical resection specifically for the lung cancer being treated
• Prior lung resection on the ipsilateral side positive for malignancy
• Patients with central tumors requiring a sleeve lobectomy or pneumonectomy
• “Ultra-central” lesions (defined as a lesion that directly contacts or overlaps the trachea, main bronchus, esophagus, or pulmonary vessels), or those for which a more extended fractionation would be required to safely treat with SBRT
• Concurrent enrollment in a therapeutic trial for the index cancer
• Synchronous primary lung cancer
• Uncontrolled or symptomatic psychiatric condition