This clinical trial investigates the impact of video education and result dependent disclosure on genetic testing uptake rates and patient outcomes in patients with a history of solid tumors. An educational video on cancer genetics may help patients learn more about the inherited causes of cancer and increase genetic testing update in patients with a history of solid tumors.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT05225428.
PRIMARY OBJECTIVES:
I. To develop a refined, streamlined, tumor agnostic, pretest video education (VE) and post-test result delivery model that results in increased genetic testing uptake and improved patient-reported outcomes for diverse patients. (Patient Interviews)
II. To evaluate the impact of pretest VE in a diverse population on intervention completion, genetic testing uptake, genetic testing satisfaction, genetic testing psychosocial impacts, genetic testing knowledge, and genetic testing family communication as reported by participants. (Randomized Controlled Trial)
SECONDARY OBJECTIVE:
I. Assess the impact of pretest VE in a diverse population on Genetic Counselors and costs to inform practice. (Randomized Controlled Trial)
OUTLINE:
PATIENT INTERVIEWS: Participants view an educational video about cancer genetics over 8-10 minutes and then participate in an interview.
GENETIC COUNSELOR INTERVIEWS: Participants participate in an interview.
GENETIC COUNSELOR SURVEY: Participants complete a survey.
RANDOMIZED CONTROLLED TRIAL: Participants are randomized to 1 of 2 arms.
ARM I: Participants view an educational video about cancer genetics. Participants may then undergo genetic testing. Participants with positive genetic testing results receive a phone call informing them of results. Participants with a negative genetic testing result or variant of uncertain significance receive a result letter informing them of results.
ARM II: Participants undergo genetic counseling per standard of care. Participants may then undergo genetic testing. Participants receive a phone call from genetic counselor informing them of genetic testing results.
Trial PhaseNo phase specified
Trial Typehealth services research
Lead OrganizationDana-Farber Harvard Cancer Center
Principal InvestigatorHuma Q Rana