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Treatment of Chimeric Antigen Receptor Expressing Autologous T Cells as Immunotherapy for Patients with Liver Cancer

Trial Status: active

This phase I trial studies the effects of immunotherapy IL-15 GPC3-CAR T cells (CATCH T cells), a specialized treatment made from T cells, a type of immune cell in your blood, can help treat those with liver cancer. Chemotherapy drugs such as cyclophosphamide and fludarabine work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. In the lab, several genes called a chimeric antigen receptor (CAR) are made, from an antibody called GC3 3. The antibody GC33 recognizes a protein called GPC3 which is found on the liver tumor. This CAR is called a GPC3-CAR. To make this CAR more effective, gene encoding a protein IL15 is also added. This protein helps CAR T cells grow better and stay in the blood longer so that they may kill tumors better. The mixture of GPC3-CAR and IL15 killed tumor cells better in the laboratory when compared with CAR T cells that did not have IL15. This study will test T cells that have been made (called genetic engineering) with the IL15 GPC3-CAR (CATCH T cells) in patients with GPC3-positive liver cancer.