An Investigational Imaging Technique (Quantitative Oblique Back Illumination Microscopy) during Brain Surgery for the Detection of Brain Tumors and Brain Tumor Margins

Inclusion Criteria

• Age >= 18 years
• Craniotomy is indicated for tumor management
• Surgery planned for 14 or fewer days from enrollment
• Evidence of a personally signed informed consent by the subject, or a legally authorized representative, indicating that the subject is aware of the neoplastic nature of the disease and has been informed of the procedures to be followed, the experimental nature of the device evaluation, alternatives, potential risks and discomforts, potential benefits, and other pertinent aspects of study participation
• A newly discovered brain lesion requiring surgery whose imaging is consistent with a new glioblastoma, astrocytoma, or oligodendroglioma or with a progressive histologically proven glioblastoma, astrocytoma, or oligodendroglioma whose management requires surgery

Exclusion Criteria

• Patients who are undergoing needle biopsy only
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements