A Study in Patients With Advanced Cancers

Inclusion Criteria

• Patients histologically or cytologically documented, locally advanced or metastatic solid tumor.
• Disease progression confirmed by imaging or other objective evidence after having received standard treatment; or patients with refractory solid tumors who cannot tolerate standard treatment or have contraindications to standard treatment.
• Measurable disease as determined by RECIST v.1.1 or bone only disease.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Key

Exclusion Criteria

• History of severe hypersensitivity to any ingredient of the study drug(s), including pembrolizumab or other monoclonal antibody. Impaired cardiac function or history of clinically significant cardiac disease
• Human Immunodeficiency virus (HIV) infection, active hepatitis B infection, or hepatitis C infection.
• Active SARS-CoV-2 infection.
• Untreated central nervous system (CNS), epidural tumor or metastasis, or brain metastasis. Other protocol defined inclusion/exclusion criteria may apply.