CPX-351 for the Treatment of Newly Diagnosed Acute Myeloid Leukemia

Inclusion Criteria

• Newly diagnosed patients > 18 years of age.
• Patients must be in complete remission (CR) or CRh (complete remission with partial count recovery).
• Must have received ANY induction treatment with standard consolidation or hypomethylating agent (HMA) + venetoclax, for up to 6 cycles or no more than one year of treatment.
• Must be able to start therapy within 3 months of last documented CR.
• De novo or secondary AML/treatment related AML (non-M3) including AML with myelodysplasia-related changes (MRC), histologically confirmed.
• Patients must be ineligible for allogeneic bone marrow transplant (BMT) (for any reason including poor performance status, patient’s preference, favorable AML not a candidate for transplant, or comorbidities and age precluding from transplant etc).
• Cardiac ejection fraction >= 50% by transthoracic echocardiography or multigated acquisition( MUGA) scan.
• Serum aspartate transaminase (AST) or alanine transaminase (ALT) =< 3 x upper limit of normal (ULN).
• Bilirubin =< 3 x ULN (unless bilirubin rise is due to Gilbert’s syndrome or of non-hepatic origin).
• Estimated Creatinine Clearance >= 30 ml/min (Cockcroft-Gault based on actual weight).
• Eastern Cooperative Oncology Group (ECOG) performance status of =< 3.
• Female subjects who are of non-reproductive potential (i.e., post-menopausal by history - no menses for >=1 year; OR history of hysterectomy; OR history of bilateral tubal ligation; OR history of bilateral oophorectomy). Female subjects of childbearing potential must have a negative serum pregnancy test upon study entry.
• Male and female subjects who agree to use highly effective methods of birth control (e.g., condoms, implants, injectables, combined oral contraceptives, some intrauterine devices [IUDs], sexual abstinence, or sterilized partner) during the period of therapy and for at least 6 months after the last dose of study drug.

Exclusion Criteria

• Prior allogeneic transplant.
• Previous cumulative anthracycline (doxorubicin equivalent) dose equal to or greater than 345 mg/m^2, and for patients with prior mediastinal chest radiotherapy (XRT), anthracycline dose equal to or greater than 295 mg/m^2.
• Acute promyelocytic leukemia [t(15;17)].
• If patient is unable to sign informed consent due to any serious medical condition, laboratory abnormality or psychiatric illness.
• Patients with evidence of uncontrolled current myocardial impairment (e.g. unstable ischemic heart disease, uncontrolled arrhythmia, symptomatic valvular dysfunction not controlled on medical therapy, uncontrolled hypertensive heart disease, and uncontrolled congestive heart failure).
• History of Wilson's disease or other copper-related disorders.
• History of allergic reactions attributed to compounds of similar composition to cytarabine and daunorubicin or liposomal products.
• History of other malignancies, except: * Malignancy treated with curative intent and with no known active disease present for >= 3 years before the first dose of study drug and felt to be at low risk for recurrence by treating physician; * Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease; * Adequately treated carcinoma in situ without evidence of disease.
• Unresolved toxicities from prior anti-cancer therapy, defined as having not resolved to Common Terminology Criteria for Adverse Event (CTCAE, version 5.0), grade =< 1, or to the levels dictated in the inclusion/exclusion criteria with the exception of alopecia.
• Known bleeding disorders (e.g., von Willebrand’s disease) or hemophilia.
• Known active infection with hepatitis C virus (HCV) or hepatitis B virus (HBV).
• Subjects with positive hepatitis B core antibody, Hepatitis B Surface antigen, hepatitis C antibody, and who have a positive polymerase chain reaction (PCR). (Subjects who have a negative PCR result for the respective disease will be eligible.).
• Any uncontrolled active systemic infection.
• Any life-threatening illness, medical condition, or organ system dysfunction that, in the investigator’s opinion, could compromise the subject’s safety or put the study outcomes at undue risk.
• Currently active, clinically significant cardiovascular disease, such as uncontrolled arrhythmia or Class 3 or 4 congestive heart failure as defined by the New York Heart Association Functional Classification; or a history of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to randomization.
• Known central nervous system (CNS) involvement by leukemia.
• History of Erythema multiforme, toxic epidermal necrolysis, or Stevens-Johnson syndrome.
• Lactating or pregnant.
• Unwilling or unable to participate in all required study evaluations and procedures.
• Unable to understand the purpose and risks of the study and to provide a signed and dated informed consent form (ICF) and authorization to use protected health information (in accordance with national and local subject privacy regulations).
• Currently active, clinically significant hepatic impairment (>= moderate hepatic impairment according to the Child Pugh classification [class B or C]).