MRS with Deuterated Glucose for Assessing Brain Metabolism in Patients with Glioma

Inclusion Criteria

• Subjects must be >= 18 years old
• Cohort 1: Healthy controls
• Cohort 2: Patients with histological proven glioma who have evidence of evaluable disease (with contrast enhancing lesion or non-enhancing lesion > 4 cc) based on a prior MR scan, Karnofsky performance status of >= 70 and life expectancy > 4 weeks
• Cohort 3: Patients with histologically proven glioma who will be undergoing any treatment, Karnofsky performance status of >= 70 and life expectancy > 12 weeks
• Subjects must not have any significant medical illness that in the investigator’s opinion cannot be adequately controlled with appropriate therapy, would compromise the subject’s ability to participate in this study or any disease that will obscure toxicity or dangerously impact response to the imaging agent
• Patients must not have a history of any other cancer unless they are in complete remission and have been off all therapy for that disease for a minimum of 3 years
• Subjects must not be pregnant or breast-feeding. Persons of childbearing potential are required to obtain a negative serum or urine pregnancy test within 14 days of the scan. Effective contraception (men and women) must be used in subjects of childbearing potentials
• Subjects must sign an informed consent indicating that they are aware of the investigational nature of the study

Exclusion Criteria

• Subjects exceeding the weight limitations of the scanner (300 pounds)
• Inability to lie still for the entire imaging time (e.g., cough, severe arthritis, etc.)
• Inability to complete the study due to other reasons (severe claustrophobia, MR incompatible medical implants or devices, inability to comply with pre-procedure fasting, etc.)
• Pre-examination blood glucose level of > 120 mg/dL as measured by point of care finger stick blood glucose test prior to MR examination
• Subjects, either healthy volunteers (recruited for cohort 1) or patients with glioma (for cohorts 2 &3), have history of diabetes mellitus