This clinical trial examines medical imaging of lesions (sites of disease) caused by the spread of prostate cancer. Medical scans help in learning how well cancer treatments works to kill prostate cancer cells and allow doctors to plan better treatment. Positron emission tomography (PET) is an established imaging technique that utilizes small amounts of radioactivity attached to very minimal amounts of tracer, that some cancers take up and can be seen with PET. CT utilizes x-rays that traverse body from the outside. Computed tomography (CT) images provide an exact outline of organs and potential inflammatory tissue where it occurs in patient’s body. Using different types of medical imaging may help researchers assess how lesions from prostate cancer become resistant to second-generation androgen resistant-targeted therapy, and how the different types of imaging compare in that assessment.
Additional locations may be listed on ClinicalTrials.gov for NCT05647564.
Locations matching your search criteria
United States
Wisconsin
Madison
University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterStatus: Active
Contact: Christos Kyriakopoulos
University of Wisconsin Carbone Cancer Center - University HospitalStatus: Active
Contact: Christos Kyriakopoulos
Phone: 608-263-0786
PRIMARY OBJECTIVES:
I. To characterize intrinsic resistance based on FDG PET/CT. ( Intrinsic Resistance Cohort)
II. To characterize intrinsic resistance based on PSMA PET/CT. (Intrinsic Resistance Cohort)
III. To characterize acquired resistance based on FDG PET/CT. (Acquired Resistance Cohort)
IV. To characterize acquired resistance based on PSMA PET/CT. (Acquired Resistance Cohort)
SECONDARY OBJECTIVES:
I. To correlate amount of resistance on FDG and PSMA PET/CT to time to PSA progression (PCWG1). (Intrinsic Resistance Cohort)
II. To correlate amount of resistance on FDG and PSMA PET/CT to time to radiographic progression (PCWG2). (Intrinsic Resistance Cohort)
III. To correlate amount of resistance on FDG and PSMA PET/CT to time to No Longer Clinical Benefit (PCWG3). (Intrinsic Resistance Cohort)
IV. To correlate amount of resistance on FDG and PSMA PET/CT to time to radiographic progression (PCWG2). (Acquired Resistance Cohort)
V. To correlate amount of resistance on FDG and PSMA PET/CT to duration on treatment (PCWG3). (Acquired Resistance Cohort)
EXPLORATORY OBJECTIVES:
I. To evaluate change in FDG to PSMA expression and how it may correlate to PSA progression (PCWG1), time to radiographic progression (PCWG2), and time to No Longer Clinical Benefit (PCWG3). (Intrinsic Resistance Cohort)
II. To evaluate change in FDG to PSMA expression and how it may correlate to time to radiographic progression (PCWG2), and time to No Longer Clinical Benefit (PCWG3). (Acquired Resistance Cohort)
OUTLINE: Patients are assigned to 1 of 2 cohorts.
COHORT A: Patients scheduled to start second-generation androgen receptor (AR)-directed therapies receive FDG via injection and undergo PET/CT on study. Patients then receive PSMA and undergo PET/CT on study. Patients also undergo collection of blood samples throughout the trial.
COHORT B: Patients being treated with second-generation AR-directed therapies and have shown an increase in their PSA levels receive FDG via injection and undergo PET/CT on study. Patients then receive PSMA and undergo PET/CT on study. Patients also undergo collection of blood samples throughout the trial.
Trial PhaseNo phase specified
Trial Typediagnostic
Lead OrganizationUniversity of Wisconsin Carbone Cancer Center - University Hospital
Principal InvestigatorChristos Kyriakopoulos