Effective Use of Buprenorphine and Opioids for the Treatment of Cancer-Related Pain

Inclusion Criteria

• Age >= 18 years
• English speaking and able to understand and sign informed consent and Health Insurance Portability and Accountability Act (HIPAA) consent document
• The patient will have pain from any cause with a pain level greater than or equal to 4 on a visual analog scale or on questions 3-6 of the BPI
• The patient will be able to complete study assessments including use of the Continuous Precision Medicine (CPM) app (requires Smart Phone)
• Patients who may become pregnant are using adequate contraceptives
• Patient is on the combination of buprenorphine and full agonist opioid > 30 mg oral morphine equivalent or being started on both buprenorphine and full agonist opioid >30 mg oral morphine equivalent at the time of enrollment

Exclusion Criteria

• Are cognitively unable to consent or have physical or mental limitations that would prevent full participation in the study
• Patient is on a long-acting opioid other than buprenorphine
• Patient is undergoing treatment for opioid use disorder
• Actively using illicit substances with the exception of medical certification of marijuana
• Pregnancy and lactation
• Known intolerance or allergy to buprenorphine
• Patients requiring rapid escalation of opioids for significant pain due to disease or treatment severity based on clinical judgement