FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3

Inclusion Criteria

• Cohort A1, C1, D1, and D2: Locally advanced or metastatic solid tumor malignancy with a qualifying FGFR3 alteration.
• Cohort A2, B2, B5 and B7: Urothelial cancer (UC) that is locally advanced or metastatic with a qualifying FGFR3 genetic alteration.
• Cohorts B1 and B4: Urothelial cancer that is locally advanced or metastatic and have received prior erdafitinib.
• Cohort B6: Muscle Invasive Bladder Cancer with a qualifying FGFR3 alteration.
• Cohort B7: Urothelial cancer that is locally advanced or metastatic with a qualifying FGFR3 genetic alteration and expression of human epidermal growth factor receptor 2 (HER2).
• Cohort B8: Low Grade Intermediate Risk Non-Muscle Invasive Bladder cancer and a qualifying FGFR3 genetic alteration.
• Measurability of disease:
• Cohort A1, D1, and D2: Measurable or non-measurable disease as defined by Response Evaluation Criteria in Solid Tumors v 1.1 (RECIST v1.1).
• Cohorts A2, B1, B2, B4, B5, B7, and C1: Measurable disease required as defined by RECIST v1.1.
• Cohort B8: Baseline disease which includes at least 1 lesion.
• Have an Eastern Cooperative Oncology Group (ECOG) performance status of:
• 0 or 1 for Cohorts A1, A2, B5, B6, B7, and B8.
• Less than or equal to 2 for Cohorts B1, B2, B4, C1, DI and D2.
• Cohort B6: Must be eligible for radical cystectomy plus pelvic lymph node dissection and agree to undergo curative intent standard radical cystectomy plus pelvic lymph node dissection.

Exclusion Criteria

• Participants with primary central nervous system (CNS) malignancy.
• Untreated or uncontrolled CNS metastases.
• Current evidence of corneal keratopathy or retinal disorder. Individuals with asymptomatic ophthalmic conditions may be eligible.
• Any serious unresolved toxicities from prior therapy.
• Significant cardiovascular disease.
• Prolongation of the QT interval corrected for heart rate using Fridericia's formula (QTcF).
• Active uncontrolled systemic infection or other clinically significant medical conditions.
• Participants who are pregnant, lactating, or plan to breastfeed during the study or within 6 months of the last dose of study treatment. Participants who have stopped breastfeeding may be enrolled.
• Cohort D1 only:
• Have had renal transplantation.
• Have a known history of nephrotic syndrome.
• Have uncontrolled fluid overload, including clinically significant ascites, pleural effusion, or peripheral edema.
• Have uncontrolled hypertension.
• Are on hemodialysis or similar.
• Cohort D2 only:
• Have a history of:
• Ventricular tachycardia or ventricular fibrillation.
• Hypertrophic obstructive cardiomyopathy unless managed concurrently with atrial fibrillation.
• Wolff-Parkinson-White syndrome.
• Second- or third-degree atrioventricular block unless a functioning pacemaker is in place.
• Heart rate less than (<) 50 bpm.
• Have any of these medical conditions:
• Severe respiratory insufficiency.
• Sleep apnea syndrome.
• Myasthenia gravis.
• Acute narrow-angle glaucoma.
• Active liver disease or clinically significant hepatic impairment.
• History of myopathy or rhabdomyolysis with any HMG-CoA reductase inhibitor.