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JV-213 Autologous CD79b-Targeting CAR-T Cell Therapy in Treating Adults with Relapsed or Refractory B-Cell Lymphomas

Trial Status: active

This phase I clinical trial tests the safety, side effects, and best dose of anti-CD79b chimeric antigen receptor (CAR) T cells (JV-213) to treat adults with B-cell lymphomas that have come back after treatment (relapsed) or that have not responded to previous treatment (refractory). CAR T-cell therapy is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added to the T cells in the laboratory. The special receptor is called a chimeric antigen receptor (CAR). Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion for treatment of certain cancers.