Exercise Therapy and Radiation Therapy for the Improvement of Quality of Life in Patients with Metastatic Prostate Cancer

Inclusion Criteria

• Subjects must have lymph node positive or metastatic disease consistent with prostate cancer
• Males >= 18 years of age receiving RT
• Patient receiving 5 fractions or stereotactic body radiation therapy (SBRT)
• Patient may have received prior hormone therapy. Prior or current use of chemotherapy agents is allowed, but not necessary
• Performance status of Eastern Cooperative Oncology Group (ECOG) =< 3
• Patient must be fluent in written and spoken English
• Patient must be able to provide and understand informed consent
• The patient’s primary attending radiation oncologist has given permission to recruit the patient

Exclusion Criteria

• Patient is performing > 90 minutes/week of exercise prior to time of enrollment
• Evidence in the medical record of an absolute contraindication for exercise
• Cardiac exclusion criteria: * Class II, III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system * History of acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty or stenting within the past 6 months prior to the start of radiation therapy * Uncontrolled arrhythmias; patients with rate-controlled atrial fibrillation for > 1 month prior to start of radiation therapy may be eligible * Syncope * Acute myocarditis, pericarditis, or endocarditis * Acute pulmonary embolus or pulmonary infarction * Thrombosis of lower extremities * Suspected dissecting aneurysm * Pulmonary edema * Respiratory failure * Acute non-cardiopulmonary disorder that may affect exercise performance or be aggravated by exercise
• Mental impairment leading to inability to complete study requirements
• In-patient receiving radiation therapy for a radiation emergency (e.g. cord compression, superior vena cava [SVC] syndrome, brain metastases)
• High risk of fracture or spine instability (Mirels score >= 7, SINS >= 7)
• Children (the protocol will only include men age 18 and older)